Micromechanical Testing of Individual Collagen Fibrils

Rijt, J.A.J. van der; Werf, Kees O. van der; Bennink, Martin L.; Dijkstra, Pieter J.; Feijén, Jan

doi:10.1002/mabi.200600063

Cited by 326 publications

(223 citation statements)

References 12 publications

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“…A very close agreement was found for hydrated collagen microfibril in the small strain regime between the FEM based results and experimental ones obtained by X-ray diffraction (Sasaki and Odajima, 1996) and also by atomic force microscopy (AFM) (Van der Rijt et al 2006;Aladin et al, 2010).…”

Section: Damping Capacitysupporting

confidence: 77%

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

Barkaoui¹,

Hambli²,

Tavares³

2014

Computer Methods in Biomechanics and Biomedical Engineering

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Bone is a multiscale heterogeneous material and its principal function is to support the body structure and to resist mechanical loads without fracturing. Numerical modelling of biocomposites at different length scales provides an improved understanding of the mechanical behaviour of structures such as bone, and also guides the development of multiscale mechanical models. Here, a three-dimensional nano-scale model of mineralized collagen microfibril based on the finite element method was employed to investigate the effect of material and structural factors on the mechanical equivalent of fracture properties.

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Section: Damping Capacitysupporting

confidence: 77%

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

Barkaoui¹,

Hambli²,

Tavares³

2014

Computer Methods in Biomechanics and Biomedical Engineering

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“…In order to clarify, the averaged elastic [Insert Table 1 about here] Fig. 7 show a very good agreement between NN predicted (present work) and experimental results in the small strain regime based on X-ray diffraction [32], atomic force microscopy (AFM) [30] and molecular dynamics (MD) computation [17].…”

Section: Resultssupporting

confidence: 71%

“…Most of works have been interested on mechanical behaviour and properties of individual MCF [29][30][31][32]. Several mechanical models have been developed in order to estimate the mechanical properties of MCFs and bone tissues [9,33] and to model the 3D orthotropic elastic properties of a single MCF [34].…”

Section: Introductionmentioning

confidence: 99%

A multiscale modelling of bone ultrastructure elastic proprieties using finite elements simulation and neural network method

Barkaoui

Tlili

Vercher-Martínez

et al. 2016

Computer Methods and Programs in Biomedicine

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“…Collagen Young's Modulus : Most reported values for the Young's modulus for collagen fibres lie in the range 200-570 MPa (Kato et al, 1988, Yang et al, 2008, Sasaki and Odajima, 1996, Gentleman et al, 2003, van der Rijt et al, 2006, Shen et al, 2008.…”

Section: Model Parametersmentioning

confidence: 99%

A structural model of passive skeletal muscle shows two reinforcement processes in resisting deformation

Gindre

Takaza

Moerman

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

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Passive skeletal muscle derives its structural response from the combination of the titin filaments in the muscle fibres, the collagen fibres in the connective tissue and incompressibility due to the high fluid content. Experiments have shown that skeletal muscle tissue presents a highly asymmetrical three-dimensional behaviour when passively loaded in tension or compression, but structural models predicting this are not available. The objective of this paper is to develop a mathematical model to study the internal mechanisms which resist externally applied deformation in skeletal muscle bulk. One cylindrical muscle fibre surrounded by connective tissue was considered. The collagenous fibres of the endomysium and perimysium were grouped and modelled as tension-only oriented wavy helices wrapped around the muscle fibre. The titin filaments are represented as non-linear tensiononly springs. The model calculates the force developed by the titin molecules and the collagen network when the muscle fibre undergoes an isochoric along-fibre stretch. The model was evaluated using a range of literature based input parameters and compared to the experimental fibre-direction stress-stretch data available. Results show the fibre direction non-linearity and tension/compression asymmetry are partially captured by this structural model. The titin filament load dominates at low tensile stretches, but for higher stretches the collagen network was responsible for most of the stiffness. The oblique and initially wavy collagen fibres account for the non-linear tensile response since, as the collagen fibres are being recruited, they straighten and re-orient. The main contribution of the model is that it shows that the overall compression/tension response is strongly influenced by a pressure term induced by the radial component of collagen fibre stretch acting on the incompressible muscle fibre. Thus for along-fibre tension or compression the model predicts that the collagen network contributes to overall muscle stiffness through two different mechanisms: 1) a longitudinal force directly opposing tension and 2) a pressure force on the muscle fibres resulting in an indirect longitudinal load. Although the model presented considers only a single muscle fibre and evaluation is limited to along-fibre loading, this is the first model to propose these two internal mechanisms for resisting externally applied deformation of skeletal muscle tissue.2

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Micromechanical Testing of Individual Collagen Fibrils

Cited by 326 publications

References 12 publications

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

A multiscale modelling of bone ultrastructure elastic proprieties using finite elements simulation and neural network method

A structural model of passive skeletal muscle shows two reinforcement processes in resisting deformation

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