Micromeritics in Pharmaceutical Product Development

Maheshwari, Rahul; Todke, Pooja; Kuche, Kaushik; Raval, Nidhi; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814423-7.00017-4

Cited by 8 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The angle of repose for all the 20 formulations, formulated was between 27.68-28.10 is the indication good owability of all the tablet blends. Similarly, the results of densities, Hausner's ratio and compressibility index also support the conclusion of optimum ow properties of tablet blends (Table 6) (Maheshwari et al, 2018).…”

Section: Micromeritic Propertiessupporting

confidence: 73%

Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV retinitis

Gundu

Pekamwar

Shelke³

et al. 2022

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Valganciclovir HCl (VGH) is the widely used drug for the treatment of Cytomegalovirus (CMV) retinitis infection with an induction dose of 900mg twice a day and a maintenance dose of 900mg. This required dose of the drug also leads to multiple side effects due to repeated administration. The research was highlighted to develop, formulate, optimize and evaluate Single-Core Osmotic Pump (SCOP) tablet of VGH with the dose of 450mg to reduce dosing frequency and associated side effects. . The decrease in dose also minimize the hepatic and nephrotic load. The optimized batch of formulation was subjected to comparative in vitro and in vivo evaluation. The tablet core composition is the primary in uencer of the drug delivery fraction in a zero-order, whereas the membrane characteristics control the drug release rate. In-vivo pharmacokinetic studies revealed that the newly developed osmotic formulation has controlled zero-order release for 24 hours with a single dose of 450mg while the marketed formulation requires twice administration within 24 hours to maintain the plasma concentration in the therapeutic window. The developed formulation can be the promising option for the treatment of CMV retinitis with the minimum dose and dosing frequency. MaterialsVGH was obtained as a free sample from Wockhardt Research Centre, Aurangabad (M.S), India, and lactose monohydrate was obtained from DFE Pharma, India.

show abstract

Section: Micromeritic Propertiessupporting

confidence: 73%

Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV retinitis

Gundu

Pekamwar

Shelke³

et al. 2022

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

show abstract

“…The average granule size of JZ 127 (4.54 mm) was larger than those of other varieties. The term micrometric represent to a study of well-derived properties of fine particle in science and technology, it is not only used in the development of pharmaceutical and material science ( 47 ), but in widely used in food science and technology for functional, pasting, and formulation ( 48 ). The micrometric properties including CI, HR, and AR, of sorghum flours were assessed.…”

Section: Resultsmentioning

confidence: 99%

“…HR did not significantly differ ( p > 0.05) in our findings. The good flow properties of granules and powders are important in products designed in compressed form like tablets, and capsules ( 47 ), and in the creation of new products, like films and coatings ( 48 ).…”

Section: Resultsmentioning

confidence: 99%

Comparative assessment of nutritional and functional properties of different sorghum genotypes for ensuring nutritional security in dryland agro-ecosystem

et al. 2022

View full text Add to dashboard Cite

The cultivation of unique sorghum (resistant to abiotic stresses and re-recognized as healthy food) has attracted interest as an environmentally friendly minor cereal and may be a solution to food and nutritional security. However, information about how the use of selected sorghum grains affects nutritive values and its functional properties from sorghum flours is still lacking. To address this question, we selected six sorghum varieties (i.e., JinZa 34, LiaoZa 19, JinNuo 3, JiZa 127, JiNiang 2, and JiaXian) for the comprehensive analysis of the relationship among nutritional compositions, energy value contributions, and functional properties of sorghum grains. Results showed that Carr’s index (CI) and angle of repose (AR) of all sorghum flours indicated good flow and compressibility properties in terms of micrometric parameters. All sorghums were considered free of tannin. Based on the scatterplot analysis, the proportions of energy contributions due to protein, fat, and carbohydrate (CHO), were highly positively correlated with protein, fat, and CHO, respectively. The significantly different flours of six sorghum varieties resulted in different functional properties. The amylose content showed a highly negative association with light transmittance and water and oil absorption capacities. In addition, amylose had a highly positive relationship with water solubility (WS) and swelling power (SP). JinNuo 3 had the highest nutritional compositions [proximate, mineral, anti-nutritional values, and amino acid (AA) profiles] and functional properties indicating that it could be used as a brewing liquor. Our findings will provide a new opportunity to cultivate sorghum as an environment friendly minor cereal crop in dryland agro-ecosystems of arid and semi-arid regions of northern China for nutritional security, agriculture processing, and non-food industry in the future.

show abstract

“…In recent year the compressibility index and the closely related Hausner's ratio have become simple, fast and popular method of predicting beads flow characteristics. Both the compressibility index and the Hausner's ratio were determine by using bulk density and tapped density of beads [31][32][33] .…”

Section: F) Hausner Ratiomentioning

confidence: 99%

“…Carr's index is a one point determination and does not always reflect the ease or speed with which the powder consolidate. It is expressed in percentage given by- [31][32][33] Carr's Index = Tapped density -Bulk density / Tapped density…”

Section: G) Carr's Indexmentioning

confidence: 99%

Preclinical Drug Development Process: Formulation and Development Aspects

Ansari¹

2023

IJMPS

View full text Add to dashboard Cite

Drug discovery and development process aims to make available new pharmacological entities to prevent, treat, mitigate or cure disease in a safe and effective manner. It involves rigorous testing and optimization of selected compounds to identify the drug that is most effective. Drug development starts with a target identification and validation, followed by drug candidate (hits) discovery, and lead drug (compound with favourable pharmaceutical, safety, efficacy and pharmacokinetic profile) selection and optimization then preclinical research, clinical research, FDA drug review, FDA post-market drug safety monitoring. In the stage of preclinical study, pharmaceutical preformulation and development and toxicity studies are the major concerns. The chapter focuses on preclinical formulations stressing upon different preclinical formulation strategies and deciphers the understanding of formulation approaches that could be employed. During preformulation studies the parameters evaluated are: solubility in different media and solvents, dissolution of the active pharmaceutical ingredient (API), accelerated stability studies under various conditions, solid state properties (polymorphs, particle size, particle shape, etc.), formulation development of new chemical entity (NCE),optimization of existing formulations, process development for selected dosage form, novel formulations for improved delivery of existing dosage forms, controlled release and sustained release formulations, micro and nano formulations, partition coefficient, pKa determination. It also emphasizes on Pharmacokinetic studies. The chapter also provides detailed information related to a vast pool of excipients available which is of immense help in designing preclinical formulations. A light is thrown on key aspects of preclinical formulation development by cited examples.

show abstract

Micromeritics in Pharmaceutical Product Development

Cited by 8 publications

References 46 publications

Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV retinitis

Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV retinitis

Comparative assessment of nutritional and functional properties of different sorghum genotypes for ensuring nutritional security in dryland agro-ecosystem

Preclinical Drug Development Process: Formulation and Development Aspects

Contact Info

Product

Resources

About