Micrometastasis to lymph nodes in stage I left lung cancer patients

Kawano, Ryoji; Hata, Enjô; Ikeda, Shingo; Sakaguchi, Hirozo

doi:10.1016/s0003-4975(02)03398-2

Cited by 26 publications

(16 citation statements)

References 9 publications

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“…In this series no metastases were found when a negative SLN was identified. However, in more than half of the patients 124, 125 no sentinel node was found. Subsequently, Liptay et al 126 reported a series of 45 cases with mapping using 99m TcSC.…”

Section: Sln Micrometastasis and Clinical Outcome In Lung Cancermentioning

confidence: 95%

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Leong

Zuber

Ferris

et al. 2011

Journal of Surgical Oncology

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The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.

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Section: Sln Micrometastasis and Clinical Outcome In Lung Cancermentioning

confidence: 95%

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Leong

Zuber

Ferris

et al. 2011

Journal of Surgical Oncology

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“…In contrast, a recent immunocytochemical study of apparently tumor-free lymph nodes did not indicate a significant prognostic impact of MRD in regional lymph nodes [166]: The 5-year survival rates of patients with and without MRD were 74.0% and 84.4%, respectively; (p = 0.54). Since only 49 patients were included in the latter survival analysis and overall survival was chosen as study end-point instead of cancer-related survival, the mentioned failure to show prognostic significance should be interpreted carefully.…”

Section: Prognostic Relevance Of Micrometastases In Regional Lymph Nodesmentioning

confidence: 68%

Molecular mechanisms of metastasis

Hoon

Kitago

Kim

et al. 2006

Cancer Metastasis Rev

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A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent years as we have discovered new metastasis-related genes and gained understanding of the molecular events of lymphatic metastasis. The symposium covered new aspects and important questions related to the events of metastasis in both humans and animals. The basic and clinical related research covered in this topic represented many disciplines. The presentations showed novel findings and at the same time, raised many new unanswered questions, indicating the limited knowledge we still have regarding the molecular events of metastasis. The hope is that further unraveling of the direct and indirect molecular events of lymphatic metastasis will lead to new approaches in developing effective therapeutics.

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“…The study of Zheng et al (2002) demonstrated that the survival of CK (+) and CK (-) patients were 32 months and 48 months, respectively (P=0.0178). In contrast to above studies, some researchers insisted on that the presence of occult metastases had no influence on survival (Poncelet et al 2001;Kawano et al 2002).…”

Section: Discussionmentioning

confidence: 93%

Detection of disseminated lung cancer cells in regional lymph nodes by assay of CK19 reverse transcriptase polymerase chain reaction and its clinical significance

Wang

et al. 2005

J Cancer Res Clin Oncol

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Comparing with HE, RT-PCR can make more accurate assessment of metastatic status in LNs, which is helpful for screening the patients in whom the early subclinical metastasis exists and disclosing the intrinsic regulation of malignant metastasis. The presence of DTCs in LNs is an independent factor for prognosis. Molecular detection of DTCs in LNs is a supplement for current tumor staging in lung carcinoma.

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Micrometastasis to lymph nodes in stage I left lung cancer patients

Cited by 26 publications

References 9 publications

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Molecular mechanisms of metastasis

Detection of disseminated lung cancer cells in regional lymph nodes by assay of CK19 reverse transcriptase polymerase chain reaction and its clinical significance

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