Micrometre and nanometre scale patterning of binary polymer brushes, supported lipid bilayers and proteins

Johnson, Alexander D.; Madsen, Jeppe; Chapman, Paul; Alswieleh, Abdullah M.; Al-Jaf, Omed; Bao, Peng; Hurley, Claire R.; Cartron, Michaël L.; Evans, Stephen D.; Hobbs, Jamie K.; Hunter, C. Neil; Armes, Steven P.; Leggett, Graham

doi:10.1039/c7sc00289k

Cited by 20 publications

(21 citation statements)

References 61 publications

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“…It is important to note that we primarily focus on planar substrates; MPBs on curved surfaces and particles have been reviewed previously and provide promising platforms for materials that can be selectively shuttled between phases in multi-component mixtures [55]. Note that there are also so-called "binary" or "ternary" polymer brushes, patterned manually in nanometer-or micron-scales (e.g., using a photomask) on a surface [56][57][58][59][60][61][62][63][64]. We do not consider these as "binary or ternary mixed polymer brushes" here, since their tethered ends are not inherently mixed on a molecular level.…”

Section: Introductionmentioning

confidence: 99%

Mixed Polymer Brushes for “Smart” Surfaces

Pester

2020

Polymers

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Mixed polymer brushes (MPBs) are composed of two or more disparate polymers covalently tethered to a substrate. The resulting phase segregated morphologies have been extensively studied as responsive “smart” materials, as they can be reversible tuned and switched by external stimuli. Both computational and experimental work has attempted to establish an understanding of the resulting nanostructures that vary as a function of many factors. This contribution highlights state-of-the-art MPBs studies, covering synthetic approaches, phase behavior, responsiveness to external stimuli as well as novel applications of MPBs. Current limitations are recognized and possible directions for future studies are identified.

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Section: Introductionmentioning

confidence: 99%

Mixed Polymer Brushes for “Smart” Surfaces

Pester

2020

Polymers

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“…For example, Bent and co-workers have exploited alkylphosphonic acid SAMs to protect copper (Cu) and induce area-selective atomic layer deposition (AS-ALD) of inorganic oxides only on silicon dioxide (SiO 2 ) . SAMs can similarly influence the spatial distribution of polymer films through phase separation, , self-assembly, localized brush growth, and thermal dewetting. , However, unlike inorganics, the majority of this past work on SAM-directed polymer thin-film patterning placed SAMs on flat, homogeneous substrates, e.g., with microcontact printing . Developing similar capabilities to selectively pattern polymer thin films on heterogeneous (e.g., metal/dielectric) surfaces would provide fundamental insight that might someday be useful in technological applications.…”

Section: Introductionmentioning

confidence: 99%

Rapid and Selective Deposition of Patterned Thin Films on Heterogeneous Substrates via Spin Coating

Zhang

D'Ambra

Katsumata

et al. 2019

ACS Appl. Mater. Interfaces

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The selective deposition of polymer thin films can be achieved via spin coating by manipulating interfacial interactions. While this “spin dewetting” approach sometimes generates spatial localization on topographic and chemical patterns, the connection between material selection, process parameters, and resulting film characteristics remains poorly understood. Here, we demonstrate that accurate control over these parameters allows incomplete trichlorosilane self-assembled monolayers (SAMs) to induce spin dewetting on both homogeneous (SiO2) and heterogeneous (Cu/SiO2 or TiN/SiO2) surfaces. Glassy polymers undergo a sharp transition from uniform wetting to complete dewetting depending on spin speed, solution concentration, polymer molecular weight, and SAM chemistry. Under optimal conditions, spin dewetting on line–space patterns results in the selective deposition of polymer over regions not functionalized with SAM. The insights described herein clarify the importance of different variables involved in spin dewetting and provide access to a versatile strategy for patterning polymeric thin films.

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“…Additionally, Garcia et al demonstrated that micro‐ and nanoscale patterns of a POEGMA brush could be created over large areas with high throughput and fidelity using a photolithography technique . Recently, Johnson et al further extended the capability of a photolithography technique to allow for high‐fidelity patterning of a binary polymer brush on a planar surfaces, which could potentially be important for the design of multifunctional surfaces …”

Section: Device‐associated Infectionsmentioning

confidence: 99%

Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces

Shi

Wang

et al. 2018

Adv Healthcare Materials

177

108

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With the rapid spreading of resistance among common bacterial pathogens, bacterial infections, especially antibiotic-resistant bacterial infections, have drawn much attention worldwide. In light of this, nanoparticles, including metal and metal oxide nanoparticles, liposomes, polymersomes, and solid lipid nanoparticles, have been increasingly exploited as both efficient antimicrobials themselves or as delivery platforms to enhance the effectiveness of existing antibiotics. In addition to the emergence of widespread antibiotic resistance, of equal concern are implantable device-associated infections, which result from bacterial adhesion and subsequent biofilm formation at the site of implantation. The ineffectiveness of conventional antibiotics against these biofilms often leads to revision surgery, which is both debilitating to the patient and expensive. Toward this end, micro- and nanotopographies, especially those that resemble natural surfaces, and nonfouling chemistries represent a promising combination for long-term antibacterial activity. Collectively, the use of nanoparticles and nanostructured surfaces to combat bacterial growth and infections is a promising solution to the growing problem of antibiotic resistance and biofilm-related device infections.

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Micrometre and nanometre scale patterning of binary polymer brushes, supported lipid bilayers and proteins

Abstract: Binary polymer brush patterns were fabricated using aminosilanes with photo-cleavable protecting groups.

Cited by 20 publications

References 61 publications

Mixed Polymer Brushes for “Smart” Surfaces

Mixed Polymer Brushes for “Smart” Surfaces

Rapid and Selective Deposition of Patterned Thin Films on Heterogeneous Substrates via Spin Coating

Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces

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