Micromolar Zn2+ potentiates the cytotoxic action of submicromolar econazole in rat thymocytes: Possible disturbance of intracellular Ca2+ and Zn2+ homeostasis

Kinazaki, Akio; Sakanashi, Yoko; Oyama, Tomohiro M.; Shibagaki, Haruka; Yamashita, Kanae; Hashimoto, Erika; Nishimura, Yumiko; Ishida, Shiro; Okano, Yoshiro; Oyama, Yasuo

doi:10.1016/j.tiv.2009.02.001

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…A relationship between changes in side scatter and disturbance of intracellular Ca 2+ homeostasis was shown in our previous study (Kinazaki et al, 2009). Therefore, to confirm whether biphenyl increased intracellular Ca 2+ levels, biphenyl-induced changes of Fluo-3 fluorescence were examined.…”

Section: Biphenyl Induced Increases In the Intracellular Ca 2+ Levelsupporting

confidence: 56%

Biphenyl increases the intracellular Ca<sup>2+</sup> concentration in HL-60 cells

Inubushi

Sugimoto

Kunimi

et al. 2018

Fundam. Toxicol. Sci.

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-Biphenyl is a universal intermediate agent used as a protectant in various industrial activities. Biphenyl is currently used in postharvest applications as a fungicide in foreign countries to maintain the safety and quality of agricultural products. However, the risk of using biphenyl is in dispute in Japan. The toxicity of biphenyl has been studied in animals, and reportedly affects the liver and kidney especially. However, the toxic effect of biphenyl on cells is currently not well-understood, and the mechanism is unclear. We examined the toxicity of biphenyl on HL60 cells, a human promyelocytic leukemia cell line, by performing flow cytometry analyses with fluorescent probes. Biphenyl at 100 μM or greater significantly increased lethality and the intensity of side scatter on HL60 cells. Moreover, biphenyl at 30 μM or greater increased intracellular Ca 2+ in a concentration-dependent manner. This increase resulted from free extracellular Ca 2+ entering into the cells. These results indicate that an increase in intracellular Ca 2+ may be one of several causes of the cytotoxicity induced by biphenyl. This study will contribute to the safety evaluation of biphenyl in the future.

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Section: Biphenyl Induced Increases In the Intracellular Ca 2+ Levelsupporting

confidence: 56%

Biphenyl increases the intracellular Ca<sup>2+</sup> concentration in HL-60 cells

Inubushi

Sugimoto

Kunimi

et al. 2018

Fundam. Toxicol. Sci.

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“…However, the differences in their cellular actions have not been elucidated to date. In our previous studies, the application of ZnCl 2 augmented the cytotoxicity of triazole antifungals (Oyama et al, 2007;Matsui et al, 2008;Kinazaki et al, 2009), non-ionic surfactants , and H 2 O 2 (Matsui et al, 2010). Since zinc is supposed to possess various cellular actions, it is important to reveal the actions of zinc supplements on the cells under oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the cellular actions of polaprezinc (zinc-l-carnosine) and ZnCl2

et al. 2012

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“…In some cases, metal ions can regulate the activity of an organic drug or vice versa without requiring the intake of the corresponding metallodrug. Such examples concerning AAs are manifold in the literature [35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery

Cortat,

Zobi

2023

Pharmaceutics

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Coordination compounds featuring one or more antifungal azole (AA) ligands constitute an interesting family of candidate molecules, given their medicinal polyvalence and the viability of drug complexation as a strategy to improve and repurpose available medications. This review reports the work performed in the field of coordination derivatives of AAs synthesized for medical purposes by discussing the corresponding publications and emphasizing the most promising compounds discovered so far. The resulting overview highlights the efficiency of AAs and their metallic species, as well as the potential still lying in this research area.

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Micromolar Zn2+ potentiates the cytotoxic action of submicromolar econazole in rat thymocytes: Possible disturbance of intracellular Ca2+ and Zn2+ homeostasis

Cited by 5 publications

References 27 publications

Biphenyl increases the intracellular Ca<sup>2+</sup> concentration in HL-60 cells

Biphenyl increases the intracellular Ca<sup>2+</sup> concentration in HL-60 cells

A comparison of the cellular actions of polaprezinc (zinc-l-carnosine) and ZnCl2

Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery

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