Microneedle arrays for cutaneous and transcutaneous drug delivery, disease diagnosis, and cosmetic aid

Kumar, Vineet; Saha, Ivy; Alam, Mahboob; Nishchaya, Kumar; Ghosh, Goutam; Rath, Goutam

doi:10.1016/j.jddst.2022.104058

Cited by 4 publications

(3 citation statements)

References 202 publications

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“…MNs were first described in a United States patent and defined as a drug delivery device with a drug reservoir and multiple projections, that can penetrate the stratum corneum , used in percutaneous administration of drugs for local or systemic therapy [ 106 ]. Since then, patches, rollers, and devices have been developed applying MNs, proving claims to enhance transdermal delivery, be minimally invasive, cause no pain upon administration, and be capable of being self-administered [ 107 , 108 , 109 ]. Microneedles can be made of metal, silicon, glass, ceramic, carbohydrates, or polymers, and are typically classified into four types: solid, coated, dissolving, and hollow and hydrogel, which have already been reviewed elsewhere [ 108 , 109 , 110 ].…”

Section: Microneedlesmentioning

confidence: 99%

“…Since then, patches, rollers, and devices have been developed applying MNs, proving claims to enhance transdermal delivery, be minimally invasive, cause no pain upon administration, and be capable of being self-administered [ 107 , 108 , 109 ]. Microneedles can be made of metal, silicon, glass, ceramic, carbohydrates, or polymers, and are typically classified into four types: solid, coated, dissolving, and hollow and hydrogel, which have already been reviewed elsewhere [ 108 , 109 , 110 ]. The most significant results found in the literature on the co-delivery of drugs applied to topical delivery employing microneedles are summarized in Table 7 .…”

Section: Microneedlesmentioning

confidence: 99%

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Co-Encapsulation of Drugs for Topical Application—A Review

et al. 2023

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Achieving the best possible outcome for the therapy is the main goal of a medicine. Therefore, nanocarriers and co-delivery strategies were invented to meet this need, as they can benefit many diseases. This approach was applied specifically for cancer treatment, with some success. However, these strategies may benefit many other clinical issues. Skin is the largest and most exposed organ of the human body, with physiological and psychological properties. Due to its exposition and importance, it is not difficult to understand how many skin diseases may impact on patients’ lives, representing an important burden for society. Thus, this review aims to summarize the state of the art in research concerning nanocarriers and co-delivery strategies for topical agents’ applications targeting skin diseases. The challenge for the medicine of the future is to deliver the drug with spatial and temporal control. Therefore, the co-encapsulation of drugs and the appropriate form of administration for them are so important and remain as unmet needs.

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Section: Microneedlesmentioning

confidence: 99%

Section: Microneedlesmentioning

confidence: 99%

Co-Encapsulation of Drugs for Topical Application—A Review

et al. 2023

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“…Microneedles are a new type of transdermal drug delivery technology [1][2][3] that, due to their advantages such as minimal invasiveness, safety, and efficiency, have been widely used for vaccination [4][5][6], local anesthesia [7,8], the treatment of diabetes [9,10], and the delivery of active cosmetic products [11,12]. Microneedles are composed of multiple nanoscale needle tips arranged neatly on a base.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Polyvinylpyrrolidone/Sodium Carboxymethyl Cellulose Soluble Microneedles

Qiang

Lü

et al. 2023

Materials

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Transdermal drug delivery is a new means of delivering drugs through the skin to achieve therapeutic effects. Microneedles have several advantages, including low cost, easy self-administration, and high delivery efficiency. Different polymers affect the morphology, mechanical properties, and drug delivery efficiency of microneedles. To study the performance and limitations of microneedles (MNs), we prepared different ratios of polymers. MNs were fabricated from polyvinylpyrrolidone (PVP) and sodium carboxymethyl cellulose (CMC-Na) using the centrifugal molding method. Needle morphology, formability, and other properties of the polymers were evaluated to compare the performances of MNs with different ratios. PVP and CMC-Na were intermixed at different ratios with water as the solvent. The soluble MNs were prepared by mold casting. The morphology, thermodynamic properties, and crystallinity were studied using scanning electron microscopy (SEM), thermogravimetric analysis (TG), differential scanning calorimetric analysis (DSC), and X-ray diffraction (XRD). The results showed that composite microneedles have good thermal stability. Among the different compositions tested, the 10% PVP/2% CMC-Na composite microneedle demonstrated the best performance with a regular surface morphology and relatively high thermal decomposition and melting temperatures. These results indicate that microneedles with appropriate ratios of two different materials possess good formability and other properties.

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