Microneedle-Assisted Permeation of Lidocaine Carboxymethylcellulose with Gelatine Co-polymer Hydrogel

Nayak, Atul; Das, Diganta Bhusan; Vladisavljević, Goran T.

doi:10.1007/s11095-013-1240-z

Cited by 49 publications

(58 citation statements)

References 44 publications

(2 reference statements)

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“…However, the delivery of drugs using MNs can be conducted in four different ways. These can be known as ''poke and patch'', ''coat and poke'', formulating the API (active pharmaceutical ingredient) with a biodegradable polymeric MN (Cheung et al, 2014;Nayak et al, 2014) or by channeling the drug through the channels of a hollow MN (Prausnitz, 2004). Multiple MN designs have been fabricated that facilitate the piercing of the SC allowing the permeation of drugs (Wei-Ze et al, 2010).…”

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

Microneedles for drug delivery: trends and progress

2014

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In recent years, there has been a surge in the research and development of microneedles (MNs), a transdermal delivery system that combines the technology of transdermal patches and hypodermic needles. The needles are in the hundreds of micron length range and therefore allow relatively little or no pain. For example, biodegradable MNs have been researched in the literature and have several advantages compared with solid or hollow MNs, as they produce non-sharp waste and can be designed to allow rapid or slow release of drugs. However, they also pose a disadvantage as successful insertion into the stratum corneum layer of the skin relies on sufficient mechanical strength of the biodegradable material. This review looks at the various technologies developed in MN research and shows the rapidly growing numbers of research papers and patent publications since the first invention of MNs (using time series statistical analysis). This provides the research and industry communities a valuable synopsis of the trends and progress being made in this field.

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Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

Microneedles for drug delivery: trends and progress

2014

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“…Franz diffusion cell (FDC) is typically adopted to determine the in vitro (IV) mass transport properties of the active molecules passing the SC [10] or the whole skin thickness [11,12]. Depending on the direction of concentration gradient and permeability, an active molecule can however diffuse both vertically and horizontally in skin tissues.…”

Section: Haimmentioning

confidence: 99%

“…In a number of recent studies, it has been discussed that MN assisted percutaneous delivery of lidocaine may be beneficial in numbing a larger surface area of skin and minimising possible clearance from predominate vertical permeation of the drug [11,12,15,16]. Parenteral administration of lidocaine may increase the chances of clearance resulting in its depleted levels in the systemic circulation [17].…”

Section: Haimmentioning

confidence: 99%

“…The optimum Lidocaine NaCMC:gel 1:2.3 microgels were prepared exactly as outlined from the methods stated in Nayak et al [11]. The reason for choosing NaCMC:gel 1:2.3 as the optimum vehicle was due to the ideal physico-chemical properties outlined in Nayak et al [11].…”

Section: Preparation Of Lidocaine Nacmc:gel Microgelsmentioning

confidence: 99%

“…The reason for choosing NaCMC:gel 1:2.3 as the optimum vehicle was due to the ideal physico-chemical properties outlined in Nayak et al [11].…”

Section: Preparation Of Lidocaine Nacmc:gel Microgelsmentioning

confidence: 99%

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