Microneedle-assisted transdermal delivery of acetylsalicylic acid (aspirin) from biopolymer films extracted from fish scales

Olatunji, Ololade; Olubowale, M.; Okereke, Chiadikaobi

doi:10.1007/s00289-017-2254-1

Cited by 21 publications

(14 citation statements)

References 13 publications

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“…Fish scales Drug delivery and wound dressing Fish scales collagen film was used to release aspirin. The concentration of aspirin after 48 h from microneedles hydrogel was 0.74 mg/mL [157]…”

Section: Corneal Tissue Engineeringmentioning

confidence: 99%

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering

et al. 2020

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The utilization of marine-based collagen is growing fast due to its unique properties in comparison with mammalian-based collagen such as no risk of transmitting diseases, a lack of religious constraints, a cost-effective process, low molecular weight, biocompatibility, and its easy absorption by the human body. This article presents an overview of the recent studies from 2014 to 2020 conducted on collagen extraction from marine-based materials, in particular fish by-products. The fish collagen structure, extraction methods, characterization, and biomedical applications are presented. More specifically, acetic acid and deep eutectic solvent (DES) extraction methods for marine collagen isolation are described and compared. In addition, the effect of the extraction parameters (temperature, acid concentration, extraction time, solid-to-liquid ratio) on the yield of collagen is investigated. Moreover, biomaterials engineering and therapeutic applications of marine collagen have been summarized.

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“…Fish scales Drug delivery and wound dressing Fish scales collagen film was used to release aspirin. The concentration of aspirin after 48 h from microneedles hydrogel was 0.74 mg/mL [157]…”

Section: Corneal Tissue Engineeringmentioning

confidence: 99%

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering

et al. 2020

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“…Recently, fully biodegradable materials have been applied in the fabrication of implantable TENGs, which are promising in human health monitoring and medical care. − Gelatin, one of the most abundant natural biomacromolecules, is widely used in food, pharmaceutical, cosmetic, and photographic applications due to its excellent attributes such as low cost, superior biocompatibility, and excellent degradability. − Gelatin is usually made from the byproducts of meat and leather industries. Because of religious culture and the risk of disease transmission, fish gelatin (FG) has gradually become an alternative to mammalian gelatin. − Moreover, FG is rich in amino acid residues with electron donor groups, which could act as electron donors and endow FG with a strong ability to lose electrons during the friction process.…”

Section: Introductionmentioning

confidence: 99%

Fish Gelatin Based Triboelectric Nanogenerator for Harvesting Biomechanical Energy and Self-Powered Sensing of Human Physiological Signals

Han

Zhang

et al. 2020

ACS Appl. Mater. Interfaces

125

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Triboelectric nanogenerator (TENG) has been proven effective in converting biomechanical energy into electrical energy, which is expected to be a new energy supply device for wearable electronics and can be utilized as a self-powered sensor. In this work, we have developed a flexible, eco-friendly, and multifunctional fish gelatin based triboelectric nanogenerator (FG-TENG) composed of fish gelatin (FG) film and poly(tetrafluoroethylene)/poly(dimethylsiloxane) (PTFE/PDMS) composite film. The open-circuit voltage (V oc), short-circuit current (I sc), and output power density of this FG-TENG could reach up to 130 V, 0.35 μA, and 45.8 μW cm–2, respectively, which were significantly higher than those of TENGs based on other commonly used positive friction materials such as aluminum foil, poly(ethylene terephthalate) (PET), and print paper. The superior performance of the FG-TENG is attributed to the strong electron-donating ability of the FG during the triboelectric process. The generated electric energy was high enough to light up 50 commercial light-emitting diodes (LEDs) directly. Importantly, owing to the high stability and excellent sensitivity of the FG-TENG, it has been used as a self-powered sensor for real-time monitoring of the human physiological signals such as finger touch, joint movement, and respiration. Furthermore, to expand the usages in real-life applications, a foldable FG-TENG was fabricated by adopting the Miura folding to monitor human movements in real time. This work provides an economical, simple, and environmental-friendly approach to fabricate a biomechanical energy harvester, which has a great potential in powering next-generation wearable electronics and monitoring human physiological signals.

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“…Preparation of FG Film. FG film was prepared by using a reported solution casting method 45 with slight modification (Figure S1a). Briefly, fish scales were cleaned with tap water to remove the impurities and dried in the sun.…”

Section: Methodsmentioning

confidence: 99%

Sustainable and Transparent Fish Gelatin Films for Flexible Electroluminescent Devices

et al. 2020

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In the past decades, various alternating current electroluminescent (ACEL) devices, especially the flexible ones, have been developed and used in flat panel display, large-scale decorating, logo display lighting, optical signaling, etc. Transparent plastics are usually used as substrates in ACEL devices; however, they are undegradable and may cause serious environmental pollution. Herein, we have developed a flexible transient ACEL device based on transparent fish gelatin (FG) films. The FG films were made from fish scales, which are sustainable, cost-efficient, and eco-friendly. These films could dissolve in water within seconds at 60 °C and degrade completely within 24 days in soil. The transmittance of these FG films was up to 91.1% in the visible spectrum, comparable to that of polyethylene terephthalate (PET) (90.4%). After forming a composite with silver nanowires (Ag NWs), the Ag NWs-FG film showed a transmittance up to 82.3% and a sheet resistance down to 22.4 Ω sq–1. The fabricated ACEL device based on the Ag NWs-FG film exhibited high flexibility and luminance up to 56.0 cd m–2. The device could be dissolved in water within 3 min. Our work demonstrates that the sustainable, flexible, and transparent FG films are a promising alternative for green and degradable substrates in the field of flexible electronics, including foldable displays, wearable devices, and health monitoring.

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Microneedle-assisted transdermal delivery of acetylsalicylic acid (aspirin) from biopolymer films extracted from fish scales

Cited by 21 publications

References 13 publications

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering

Fish Gelatin Based Triboelectric Nanogenerator for Harvesting Biomechanical Energy and Self-Powered Sensing of Human Physiological Signals

Sustainable and Transparent Fish Gelatin Films for Flexible Electroluminescent Devices

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