Microneedle-based transdermal detection and sensing devices

Abstract

This review summarizes state-of-the-art microneedle-based detection and sensing systems, highlighting the objective significance, sensing principles, systematic construction, and validation models of these microneedles.

Wearable Clinic: From Microneedle‐Based Sensors to Next‐Generation Healthcare Platforms

“…Recent studies have reported colorimetric-based microneedle tattoos which can provide naked eye-perceptive patterns for physiological monitoring. [90][91] He et al developed a microneedle-delivered dermal tattoo biosensor composed of four responsive areas which showed visually readable color changes for multiplexed detection. [92] Colorimetric reagents were delivered into the dermis by microneedle patches to reflect the concentration-dependent changes of chronic diseases related biomarkers including pH, glucose, uric acid, and temperature (Figure 3a,i).…”

“…Recent studies have reported colorimetric‐based microneedle tattoos which can provide naked eye‐perceptive patterns for physiological monitoring. [ 90–91 ] He et al. developed a microneedle‐delivered dermal tattoo biosensor composed of four responsive areas which showed visually readable color changes for multiplexed detection.…”

Gold Nanocluster-Based Fluorescent Microneedle Platform toward Visual Detection of ATP

“…Microneedles (MNs), an array of miniaturized needles at micrometer scales, are small and minimally invasive and can be combined with other detection technologies, which have unique advantages for in situ detection. − Compared with conventional sampling methods that usually need multiple steps or extra devices, MNs can extract analytes more easily and efficiently through capillary force or negative pressure. − Particularly, hydrogel MNs have shown great potential in developing point-of-care sensing devices because of their excellent swelling ability, good biodegradability, and biocompatibility. − For example, Al Sulaiman et al . developed MNs that are coated with an alginate-peptide nucleic acid (PNA) hybrid material for sequence-specific detection of nucleic acid from the skin interstitial fluid.…”

Recent advances of biosensors on microneedles

“…With its good selectivity, high sensitivity, fast analysis, low cost, and online continuous monitoring in complex systems, especially the high degree of automation, miniaturization and integration, it can also capture the characteristics of human biomarkers, 5–8 revolutionizing the diagnosis and treatment of disease and greatly improving the quality of human life in the field of biomedical sensors. 9,10 A biosensor, comprising a sensing element and a transducer, represents an analytical device. The first commercially viable biosensor was the glucose sensor, designed for monitoring blood glucose levels.…”