Microneedle, bio-microneedle and bio-inspired microneedle: A review

Ma, Guojun; Wu, Chengwei

doi:10.1016/j.jconrel.2017.02.011

Cited by 343 publications

(210 citation statements)

References 126 publications

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“…In this context, this means the majority of nanostructures we review here are less than 10 µm high, with sub‐micron tips (with a few exceptions), see Figure . We do not consider micropatches (also referred to as microneedles) in this review, which can share similar aspect ratios, but have heights an order of magnitude larger …”

Section: Introductionmentioning

confidence: 99%

High‐Aspect‐Ratio Nanostructured Surfaces as Biological Metamaterials

et al. 2020

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Materials patterned with high‐aspect‐ratio nanostructures have features on similar length scales to cellular components. These surfaces are an extreme topography on the cellular level and have become useful tools for perturbing and sensing the cellular environment. Motivation comes from the ability of high‐aspect‐ratio nanostructures to deliver cargoes into cells and tissues, access the intracellular environment, and control cell behavior. These structures directly perturb cells' ability to sense and respond to external forces, influencing cell fate, and enabling new mechanistic studies. Through careful design of their nanoscale structure, these systems act as biological metamaterials, eliciting unusual biological responses. While predominantly used to interface eukaryotic cells, there is growing interest in nonanimal and prokaryotic cell interfacing. Both experimental and theoretical studies have attempted to develop a mechanistic understanding for the observed behaviors, predominantly focusing on the cell–nanostructure interface. This review considers how high‐aspect‐ratio nanostructured surfaces are used to both stimulate and sense biological systems.

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Section: Introductionmentioning

confidence: 99%

High‐Aspect‐Ratio Nanostructured Surfaces as Biological Metamaterials

et al. 2020

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“…Oka et al developed one of the first mimics inspired by mosquito mouthparts (proboscis), [482] and they have been followed by designs based on caterpillar spines [483] and others. [484] Research in the microneedle field continues to grow, and the multitude of skinpiercing organs in insects have a wealth of insight to offer in this effort.…”

Section: Anatomical Structures For Allomone Injectionmentioning

confidence: 99%

It's Not a Bug, It's a Feature: Functional Materials in Insects

2018

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Over the course of their wildly successful proliferation across the earth, the insects as a taxon have evolved enviable adaptations to their diverse habitats, which include adhesives, locomotor systems, hydrophobic surfaces, and sensors and actuators that transduce mechanical, acoustic, optical, thermal, and chemical signals. Insect‐inspired designs currently appear in a range of contexts, including antireflective coatings, optical displays, and computing algorithms. However, as over one million distinct and highly specialized species of insects have colonized nearly all habitable regions on the planet, they still provide a largely untapped pool of unique problem‐solving strategies. With the intent of providing materials scientists and engineers with a muse for the next generation of bioinspired materials, here, a selection of some of the most spectacular adaptations that insects have evolved is assembled and organized by function. The insects presented display dazzling optical properties as a result of natural photonic crystals, precise hierarchical patterns that span length scales from nanometers to millimeters, and formidable defense mechanisms that deploy an arsenal of chemical weaponry. Successful mimicry of these adaptations may facilitate technological solutions to as wide a range of problems as they solve in the insects that originated them.

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“…This is what happened to the micro-and nanotechnologies that have revolutionized consumer electronics and telecommunications. [10,11] In these papers, the MNs are classified on the basis of their material (silicon, metal, glass, ceramic, polymer), shape (pyramidal, conical, solid, hollow, coated), bio-features (dissolvable, degradable, biocompatible, bioresponsive), and finally fabrication process (multistep, single step). [4] The convergence of such different fields of knowledge has generated a multitude of similar devices grouped under the single name of microneedles, which can be very different in terms of the materials used, fabrication procedures, and features exploited.…”

Section: One Device Several Technologiesmentioning

confidence: 99%

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

Dardano

Battisti²,

Rea

et al. 2019

Advanced Therapeutics

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Mainly designed and realized as a painless alternative to the hypodermic syringe, microneedle-based devices are currently approaching commercial market placement. The considerable academic and industrial investment in this technology is reflected by a multitude of papers published and patents registered every year, which is also a sign of a field in full fermentation. New materials and innovative methodologies are continuously exploited in search of the best performance at the lowest cost. For these reasons, an updated review, focused predominantly on the last year of scientific production, is a useful guideline in this rapidly changing panorama. This report provides a critical review of microneedle technologies presented in the very recent literature with a particular focus on those closest to the needs of the healthcare field. Although a few devices are already commercial, further effort is still needed to achieve complete clinical translation and therapeutic efficacy competitive with or superior to those of the devices used as standards and adopted by national health systems.

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Microneedle, bio-microneedle and bio-inspired microneedle: A review

Cited by 343 publications

References 126 publications

High‐Aspect‐Ratio Nanostructured Surfaces as Biological Metamaterials

High‐Aspect‐Ratio Nanostructured Surfaces as Biological Metamaterials

It's Not a Bug, It's a Feature: Functional Materials in Insects

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

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