Microneedle‐mediated intradermal delivery of epigallocatechin‐3‐gallate

Abstract

Addition of glutathione in EGCG formulations significantly reduces its photodegradation. Skin microporation with maltose microneedles facilitates the penetration of EGCG across the stratum corneum into the deeper skin layers - viable epidermis and dermis.

Development of a method for quantitative determination of the cytotoxic agent piplartine (piperlongumine) in multiple skin layers

“…The average basal transepidermal water loss observed was ~12 g/cm 2 h; sections with higher values were not used. This is close to ranges previously reported using the same device and frozen porcine skin, but variations have been observed (Elmahjoubi, Frum, Eccleston, Wilkinson, & Meidan, ; Jacques‐Jamin et al, ; Puri, Nguyen, & Banga, ). It has been recognized that devices have different measurement ranges and that there are no standard methods for coupling the measurement chamber to the Franz cells and for device calibration (with disagreements between manufacturers and instruments), which reflects the reported variations in values (Elmahjoubi et al, ).…”

Activity of catechins and their applications

“…Has an anti-allergenic component and antiinflammatory and anti-arthritic activity Ohmori et al 1995, Marques et al 2018, Foyet et al 2015, Magalhães et al 2009 Anti-viral activities Shows anti-influenza activity and interferes with cell infiltration and attachment of herpes simplex virus Ide et al 2014, Cheng 2006 Anti-cancer activities Extract from Lawsonia inermis (Henna) can inhibit proliferation of cancer cells Kumar et al 2016 Activation of skin barrier passage Various methods have enhanced the skin penetration of epigallocatechin-3-gallate (EGCG) anti-oxidants Puri et al 2016, Zillich et al 2013, dal Belo et al 2009, Kadhum et al 2017, Bombardelli 1991, Arct et al 2002, Yang et al 2015c, Wisuitiprot et al 2011 Promoting cell activities Effective for low cytotoxicity and anti-melanin production and improves reactive oxygen species (ROS)-mediated cell viability and cell proliferation Kim et al 2015 Sludge utilisation Anti-oxidant components were extracted from various sludge, suggesting that they could be developed into foods, cosmetics, and pharmaceuticals Aires et al 2016, Magalhães et al 2015, Reis et al 2016, Kosińska et al 2012, Arruda et al 2017, Hernández-Hernández et al 2018, Sharma et al 2013, Demoliner et al 2018, Oliveira et al 2013 Stability Aspects exploited for improving stability include sunlight, oxidation, compound stability, and collagen stabilisation Scalia et al 2013, Ferreira-Nunes et al 2018, Jang et al 2014, Bianchi et al 2011, Madhan et al 2005, Gallego et al 2017 Relatively stable at low pH and the extraction efficiency of anti-oxidants was high Tsuchiya et...…”

“…Microneedle-mediated intradermal delivery enables EGCG to penetrate to deeper skin layers. Skin microporation with maltose microneedles facilitates the penetration of EGCG across the stratum corneum into the deeper skin layers, including the viable epidermis and dermis (Puri et al 2016). Based on the use of oil-water emulsions with different oil contents, a mixture of polyphenols containing catechins using Franz-type diffusion cells permeated the epidermis and dermis in pig skin in vitro (Zillich et al 2013).…”

In Vitro Antioxidant, Anti-Inflammatory and Skin Permeation of Myrsine africana and Its Isolated Compound Myrsinoside B

“…The skin sample was scanned under the confocal microscope at an excitation wavelength of 496 nm. X-Z sectioning was used to estimate the depth of the microchannels by capturing a series of images at the same location but fromdifferent depths(from theskinsurfacetothe pointwhereno fluorescent signal was observed) (Puri et al, 2016).…”