Microneedle-Mediated Minimally Invasive Patient Monitoring

Donnelly, Ryan F.; Mooney, Karen; Caffarel–Salvador, Ester; Torrisi, Barbara M.; Eltayib, Eyman Mohamed; McElnay, James

doi:10.1097/ftd.0000000000000022

Cited by 82 publications

(61 citation statements)

References 35 publications

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“…6 Collection of ISF biomarkers has been studied using hollow microneedles to withdraw fluid under suction 7 or collect biomarkers by passive diffusion through the microneedle bores, 8,9 solid microneedles with sensors designed to measure ISF biomarkers in situ in the skin, 10,11 solid microneedles to puncture the skin and withdraw fluid through the resulting holes, 12 solid microneedles coated with capture antibody to collect specific antigens, 13 and hydrogel microneedle patches that swell and thereby collect ISF over time. 14,15 …”

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confidence: 99%

Collection of Analytes from Microneedle Patches

et al. 2014

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Clinical medicine and public health would benefit from simplified acquisition of biological samples from patients that can be easily obtained at point of care, in the field, and by patients themselves. Microneedle patches are designed to serve this need by collecting dermal interstitial fluid containing biomarkers without the dangers, pain, or expertise needed to collect blood. This study presents novel methods to collect biomarker analytes from microneedle patches for analysis by integration into conventional analytical laboratory microtubes and microplates. Microneedle patches were made out of cross-linked hydrogel composed of poly(methyl vinyl ether-alt-maleic acid) and poly(ethylene glycol) prepared by micromolding. Microneedle patches were shown to swell with water up to 50-fold in volume, depending on degree of polymer cross-linking, and to collect interstitial fluid from the skin of rats. To collect analytes from microneedle patches, the patches were mounted within the cap of microcentrifuge tubes or formed the top of V-bottom multiwell microplates, and fluid was collected in the bottom of the tubes under gentle centrifugation. In another method, microneedle patches were attached to form the bottom of multiwell microplates, thereby enabling in situ analysis. The simplicity of biological sample acquisition using microneedle patches coupled with the simplicity of analyte collection from microneedles patches integrated into conventional analytical equipment could broaden the reach of future screening, diagnosis, and monitoring of biomarkers in healthcare and environmental/workplace settings.

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Collection of Analytes from Microneedle Patches

et al. 2014

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“…The use of microneedle (MN) arrays for skin interstitial fluid (ISF) monitoring represents one minimally invasive approach being explored as an alternative to traditional blood sampling [9]. MN arrays can be manufactured using various materials including silicon, metals and biocompatible polymers, with MN heights ranging between 50 and 900 μm [9]. When applied to the skin, these MNs penetrate the skins outermost stratum corneum layer, avoiding the nerves and blood vessels found in deeper layers.…”

Section: Introductionmentioning

confidence: 99%

Parents’ perceptions of microneedle-mediated monitoring as an alternative to blood sampling in the monitoring of their infants

Mooney

McElnay

Donnelly

2015

International Journal of Pharmacy Practice

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“…Although some of these (e.g. ISF sampling via microneedles 34 ) seem promising, currently, their use in routine TDM laboratories is nonexisting or limited at best.…”

Section: Tdmmentioning

confidence: 99%

Opening the toolbox of alternative sampling strategies in clinical routine: A key-role for (LC-)MS/MS

Velghe

Capiau

Stove

2016

TrAC Trends in Analytical Chemistry

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Alternative sampling strategies such as dried blood sampling, liquid microsampling and the sampling of oral fluid, hair, meconium, interstitial fluid, sweat, exhaled breath condensate and sputum offer interesting opportunities for many applications in clinical routine. Here, we provide an overview of different applications, with special attention to the pivotal role of LC-MS/MS in facilitating analysis of the collected matrices. Covered clinical fields include newborn screening, endocrinology, therapeutic drug monitoring, phenotyping, toxicology, proteomics and metabolomics. Furthermore, specific advantages, challenges and limitations of each alternative sampling strategy are discussed, along with recent advances and future trends that may contribute to routine implementation of these sampling strategies. Given the development of many recent potentially valuable clinical applications, the possibility of home sampling and the opportunity to obtain information that is hard to procure using traditional sampling, a well-balanced role for alternative sampling strategies can be envisaged in patient healthcare in the (near) future.

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Microneedle-Mediated Minimally Invasive Patient Monitoring

Abstract: It is our view that microneedles will have an important role to play in clinical management of patients and will ultimately improve therapeutic outcomes for people worldwide.

Cited by 82 publications

References 35 publications

Collection of Analytes from Microneedle Patches

Collection of Analytes from Microneedle Patches

Parents’ perceptions of microneedle-mediated monitoring as an alternative to blood sampling in the monitoring of their infants

Opening the toolbox of alternative sampling strategies in clinical routine: A key-role for (LC-)MS/MS

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