Microneedle-mediated transdermal delivery of FK506 for treatment of acute cardiac allograft rejection

Deng, Cheng; Wang, Chenyuan; Fu, Wenpei; Wu, Lujuan; Jin, Qiaofeng; Zhang, Li; Zhang, Wen; Li, Wei; Xie, Mingxing

doi:10.1016/j.matdes.2023.112415

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2024

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Cited by 2 publications

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“…The upregulation of IL-6 expression indicates an enhanced inflammatory response, which may limit the clinical application of MNs. 52,53 Therefore, the IL-6 immunohistochemistry staining of skin sections treated with prepared MNs for 12 and 24 h was performed. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

Wang,

Sun,

Wang

et al. 2024

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

Wang,

Sun,

Wang

et al. 2024

J. Mater. Chem. B

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Microneedle system for tissue engineering and regenerative medicines: a smart and efficient therapeutic approach

Khan,

Aslam,

Abdullah

et al. 2024

Biofabrication

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The global demand for an enhanced quality of life and extended lifespan has driven significant advancements in tissue engineering and regenerative medicine. These fields utilize a range of interdisciplinary theories and techniques to repair structurally impaired or damaged tissues and organs, as well as restore their normal functions. Nevertheless, the clinical efficacy of medications, materials, and potent cells used at the laboratory level is always constrained by technological limitations. A novel platform known as adaptable microneedles has been developed to address the abovementioned issues. These microneedles offer a solution for the localized distribution of various cargos while minimizing invasiveness. Microneedles provide favorable patient compliance in clinical settings due to their effective administration and ability to provide a painless and convenient process. In this review article, we summarized the most recent development of microneedles, and we started by classifying various microneedle systems, advantages, and fundamental properties. Subsequently, it provides a comprehensive overview of different types of microneedles, the material used to fabricate microneedles, the fundamental properties of ideal microneedles, and their applications in tissue engineering and regenerative medicine, primarily focusing on preserving and restoring impaired tissues and organs. The limitations and perspectives have been discussed by concluding their future therapeutic applications in tissue engineering and regenerative medicines.

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Microneedle-mediated transdermal delivery of FK506 for treatment of acute cardiac allograft rejection

Cited by 2 publications

References 37 publications

Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

Microneedle system for tissue engineering and regenerative medicines: a smart and efficient therapeutic approach

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