Microneedle Patches: 3D Printed Microheater Sensor‐Integrated, Drug‐Encapsulated Microneedle Patch System for Pain Management (Adv. Healthcare Mater. 23/2019)

Yin, Mengtian; Xiao, Li; Liu, Qingchang; Kwon, Sung‐Yun; Zhang, Yi; Sharma, Poonam; Jin, Li; Li, Xudong; Xu, Baoxing

doi:10.1002/adhm.201970093

Cited by 6 publications

(9 citation statements)

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“…With the increase in heat, the system became active and started to release the drug. [236] An intelligent system was developed utilizing the temperatureresponsive N-isopropylacrylamide (NIPAM) hydrogel and incorporated into MNs in order to achieve controlled drug release. Body temperature has been seen as an indication of wound infection.…”

Section: Applicationsmentioning

confidence: 99%

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Ertas,

Erdem

et al. 2024

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Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture the stratum corneum layer of the skin and have lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, and drug administration. MNs offer limited invasiveness, ease of application, and minimal discomfort. Initially manufactured solely from metals, MNs are now available in polymer‐based varieties. MNs can be used to create systems that deliver drugs and chemicals uniformly, collect bodily fluids, and are stimulus‐sensitive. Although these advancements are favorable in terms of biocompatibility and production costs, they are insufficient for the therapeutic use of MNs. This is the first comprehensive review that discusses individual MN functions toward the evolution and development of smart and multifunctional MNs for a variety of novel and impactful future applications. The study examines fabrication techniques, application purposes, and experimental details of MN constructs that perform multiple functions concurrently, including sensing, drug‐molecule release, sampling, and remote communication capabilities. It is highly likely that in the near future, MN‐based smart devices will be a useful and important component of standard medical practice for different applications.

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Section: Applicationsmentioning

confidence: 99%

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Ertas,

Erdem

et al. 2024

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“…[ 130 ] For example, 3D‐printed crack‐free stretchable microheaters made from PDMS and MWCNTs were adhered to drug‐encapsulated MnPs to enable temperature‐regulated drug delivery rates. [ 131 ] The microheaters exhibited high adhesion strength with MnPs made of carboxymethyl cellulose and high heating efficiency with temperature increased from 20 to above 80 °C within 150 s at 50 V. Cy5 drug was applied to evaluate the release performance of the MnPs on rat skin based on an established model. With the aid of micro‐heaters, more Cy5 drug was released from the MnPs in a shorter time than MnPs without heating, as indicated by the higher fluorescence intensity.…”

Section: Mnps‐based Transdermal Bioelectronicsmentioning

confidence: 99%

Microneedle Patches‐Integrated Transdermal Bioelectronics for Minimally Invasive Disease Theranostics

Wang,

Xiao,

et al. 2024

Adv Healthcare Materials

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Wearable epidermal electronics with non‐ or minimally‐invasive characteristics can collect, transduce, communicate, and interact with accessible physicochemical health indicators on the skin. However, due to the stratum corneum layer, rich information about body health is buried under the skin stratum corneum layer, e.g., in the skin interstitial fluid. Microneedle patches are typically designed with arrays of special microsized needles of length within 1000 μm. Such characteristics potentially enable the access and sample of biomolecules under skin or give therapeutical treatment painlessly and transdermally. Integrating microneedle patches with various electronics allows highly efficient transdermal bioelectronics, showing their great promise for biomedical and healthcare applications. This comprehensive review summarizes and highlights the recent progress on integrated transdermal bioelectronics based on microneedle patches. The design criteria and state‐of‐the‐art fabrication techniques for such devices are initially discussed. Next, devices with different functions, including but not limited to health monitoring, drug delivery, and therapeutical treatment, are highlighted in detail. Finally, key issues associated with current technologies and future opportunities are elaborated to sort out the state of recent research, point out potential bottlenecks, and provide future research directions.This article is protected by copyright. All rights reserved

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“…Microneedles integrated with a 3D‐printed microheater device were also introduced to regulate the drug delivery rate. [ 240 ] The microheater enhanced the diffusion rate of the drug molecules, which was controlled by changing the temperature of the microheater device. This study raised the possibility of developing an on‐demand dose‐controllable drug delivery system.…”

Section: Applicationsmentioning

confidence: 99%

Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

Lee,

Lim,

Kwak

et al. 2023

Adv Healthcare Materials

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Skin‐mediated drug delivery methods currently are receiving significant attention as a promising approach for the enhanced delivery of drugs through the skin. Skin‐mediated drug delivery offers the potential to overcome the limitations of traditional drug delivery methods, including oral administration and intravenous injection. The challenges associated with drug permeation through layers of skin, which act as a major barrier, are explored, and strategies to overcome these limitations are discussed in detail. This review categorizes skin‐mediated drug delivery methods based on the means of increasing drug permeation, and it provides a comprehensive overview of the mechanisms and techniques associated with these methods. In addition, recent advancements in the application of skin‐mediated drug delivery are presented. The review also outlines the limitations of ongoing research and suggests future perspectives of studies regarding the skin‐mediated delivery of drugs.

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Microneedle Patches: 3D Printed Microheater Sensor‐Integrated, Drug‐Encapsulated Microneedle Patch System for Pain Management (Adv. Healthcare Mater. 23/2019)

Cited by 6 publications

References 0 publications

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Microneedle Patches‐Integrated Transdermal Bioelectronics for Minimally Invasive Disease Theranostics

Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

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