Microneedles-based drug delivery strategies: A breakthrough approach for the management of pain

Priya, Sakshi; Singhvi, Gautam

doi:10.1016/j.biopha.2022.113717

Cited by 28 publications

(6 citation statements)

References 66 publications

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“…These molecules have been systematically investigated for their practicability as an alternative to traditional delivery methods for local anesthetics. 56 , 57 A study by Baek et al 58 on lidocaine-coated poly(L-lactide) (PLLA) microneedle arrays revealed rapid local anesthesia in a painless manner. In their experiments, lidocaine was released into phosphate-buffered saline (PBS) within two minutes and remained stable for up to three weeks at different temperatures.…”

Section: Current Drug Delivery Systems For Local Anestheticsmentioning

confidence: 99%

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

Ma,

Pan,

Lai

et al. 2023

DDDT

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From a clinical perspective, local anesthetics have rather widespread application in regional blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer treatments. However, a number of disadvantages are associated with traditional local anesthetic agents as well as routine drug delivery administration ways, such as neurotoxicity, short half-time, and non-sustained release, thereby limiting their application in clinical practice. Successful characterization of drug delivery systems (DDSs) for individual local anesthetic agents can support to achieve more efficient drug release and prolonged duration of action with reduced systemic toxicity. Different types of DDSs involving various carriers have been examined, including micromaterials, nanomaterials, and cyclodextrin. Among them, nanotechnology-based delivery approaches have significantly developed in the last decade due to the low systemic toxicity and the greater efficacy of non-conventional local anesthetics. Multiple nanosized materials, including polymeric, lipid (solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions), metallic, inorganic non-metallic, and hybrid nanoparticles, offer a safe, localized, and long-acting solution for pain management and tumor therapy. This review provides a brief synopsis of different nano-based DDSs for local anesthetics with variable sizes and structural morphology, such as nanocapsules and nanospheres. Recent original research utilizing nanotechnology-based delivery systems is particularly discussed, and the progress and strengths of these DDSs are highlighted. A specific focus of this review is the comparison of various nano-based DDSs for local anesthetics, which can offer additional indications for their further improvement. All in all, nano-based DDSs with unique advantages provide a novel direction for the development of safer and more effective local anesthetic formulations.

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Section: Current Drug Delivery Systems For Local Anestheticsmentioning

confidence: 99%

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

Ma,

Pan,

Lai

et al. 2023

DDDT

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“…The MNs array penetrates the stratum corneum, delivers the drug with a minimally invasive action, and provides drug diffusion into the tumor areas [ 11 ]. The MNs are available in various shapes and are sized with a height ranging from 150 to 1500 µm and a width ranging from 50 to 250 µm [ 12 , 13 , 14 ]. MNs have a synergistic combination of the transdermal patch with hypodermic needles, wherein a drug is directly delivered via the micro-channels to the site of tumor, especially in breast, prostate, cervical, and skin tumors.…”

Section: Microneedles In Cancer Therapy and Diagnosismentioning

confidence: 99%

“…Three-dimensional printing is a newer technique that enables MNs fabrication in a single step, as well as specific customizations. This technique also utilizes a computer-aided design model that precisely place the material in a layer-by-layer pattern to produce MNs with the desired shape and geometry [ 13 , 14 ]. The general characteristics of MNs are shown in Figure 2 .…”

Section: Microneedles In Cancer Therapy and Diagnosismentioning

confidence: 99%

Revolutionizing Therapeutic Delivery with Microneedle Technology for Tumor Treatment

et al. 2022

Self Cite

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The tumor is an uncontrolled growth of tissue that can be localized (benign) or possesses the capability of metastasis (malignant). The conventional methods of tumor diagnosis, such as acupuncture, endoscopy, and histopathology, and treatment methods, such as injections, chemotherapy, surgery, and radiotherapy, are invasive, expensive, and pose severe safety and management issues for the patients. Microneedle technology is a recently developed approach for active transdermal drug delivery. It is minimally invasive, self-administrable, bypasses the first-pass effect, and effectively delivers chemotherapeutics and drugs at low doses, thus, overcoming the drawbacks of conventional delivery systems. This review provides an idea of the types, materials utilized in the fabrication, and techniques used for the preparation of microneedles (MNs), as well as their application in tumor diagnosis and treatment. Additionally, emphasis is given to the case studies related to MNs-assisted tumor therapy, such as photothermal therapy, gene therapy, photodynamic therapy, chemotherapy, immunotherapy, and various combination therapies. MNs also serve as a tool for diagnosis by the bio-sampling of blood and interstitial skin fluid, as well as biosensing various cancer biomarkers. The combined therapy and diagnostics provide theranostic MNs for enhanced and personalized tumor therapy. The limitations and prospects of MNs development are also discussed.

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“…However, polymeric micelles are mainly administered orally, and there are problems such as poor drug absorption, first-pass effect, low bioavailability, and so on. Microneedle (MN) technology, − on the other hand, is a transdermal delivery method that uses a micron-sized array to puncture the skin stratum corneum and form micron-sized pores to realize drug delivery to the subcutaneous area, and then the drug is absorbed through the subcutaneous blood vessels and enters into the body circulation to play a role. , Microneedles can deliver a wide range of therapeutic substances, including small molecules, macromolecules, insoluble drugs and cells, which is a novel delivery modality with great potential. Microneedle transdermal drug delivery avoids the complexities of the gastrointestinal environment and offers compelling opportunities to improve the absorption and bioavailability of orally administered drugs. , …”

Section: Introductionmentioning

confidence: 99%

Hybrid Microneedle-Mediated Transdermal Delivery of Atorvastatin Calcium-Loaded Polymeric Micelles for Hyperlipidemia Therapy

Ou Yang,

Hu,

Feng

et al. 2024

ACS Appl. Bio Mater.

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Hyperlipidemia has been a huge challenge to global health, leading to the cardiovascular disease, hypertension, and diabetes. Atorvastatin calcium (AC), a widely prescribed drug for hyperlipidemia, faces huge challenges with oral administration due to poor water solubility and hepatic first-pass effects, resulting in low therapeutic efficacy. In this work, we designed and developed a hybrid microneedle (MN) patch system constructed with soluble poly(vinyl alcohol) (PVA) and AC-loaded polymeric micelles (AC@PMs) for transdermal delivery of AC to enhance the hyperlipidemia therapy. We first prepared various AC@PM formulations self-assembled from mPEG–PLA and mPEG–PLA-PEG block copolymers using a dialysis method and evaluated the physicochemical properties in combination with experiment skills and dissipative particle dynamics (DPD) simulations. Then, we encapsulated the AC@PMs into the PVA MN patch using a micromold filling method, followed by characterizing the performances, especially the structural stability, mechanical performance, and biosafety. After conducting in vivo experiments using a hyperlipidemic rat model, our findings revealed that the hybrid microneedle-mediated administration exhibited superior therapeutic efficacy when compared to oral delivery methods. In summary, we have successfully developed a hybrid microneedle (MN) patch system that holds promising potential for the efficient transdermal delivery of hydrophobic drugs.

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Microneedles-based drug delivery strategies: A breakthrough approach for the management of pain

Cited by 28 publications

References 66 publications

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

Revolutionizing Therapeutic Delivery with Microneedle Technology for Tumor Treatment

Hybrid Microneedle-Mediated Transdermal Delivery of Atorvastatin Calcium-Loaded Polymeric Micelles for Hyperlipidemia Therapy

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