Microneedles-mediated drug delivery system for the diagnosis and treatment of melanoma

Liu, Cheng; Zhao, Zhining; Lv, Hongqian; Yu, Jia; Zhang, Peng

doi:10.1016/j.colsurfb.2022.112818

Cited by 11 publications

(3 citation statements)

References 160 publications

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“…Since then, the research on MNs has shown a spurt in development [ 48 ]. And the main methods for preparing MNs are: micromolding, mapping lithography, thermal drawing, electro-drawing, magnetorheological drawing lithography, additive manufacturing (3D printing) [ 42 , [49] , [50] , [51] , [52] ]. Based on the mechanism of drug delivery, MNs can be classified as solid, hollow, coated, dissolving, and hydrogel-forming (as shown in Fig.…”

Section: Design Principles Of Functional Mns For Istrmentioning

confidence: 99%

Microneedles for in situ tissue regeneration

Long¹,

Ji²,

Hu³

et al. 2023

Materials Today Bio

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Section: Design Principles Of Functional Mns For Istrmentioning

confidence: 99%

Microneedles for in situ tissue regeneration

Long¹,

Ji²,

Hu³

et al. 2023

Materials Today Bio

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“…Taking melanoma as an example, the biomarkers of melanoma include P16, BRAF V600E, S100B, NRAS, and ALK. The detection of these markers can effectively diagnose melanoma [ 70 ]. However, the routine means of extracting biological samples not only brings serious physical trauma but also requires corresponding histological treatment and nursing of patients [ 141 , 142 ].…”

Section: Mn-mediated Treatment and Diagnosis Of Superficial Tumorsmentioning

confidence: 99%

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Wang

et al. 2023

Drug Deliv. and Transl. Res.

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Superficial tumors are still challenging to overcome due to the high risk and toxicity of surgery and conventional chemotherapy. Microneedles (MNs) are widely used in the treatment of superficial skin tumors (SST) due to the high penetration rate of the stratum corneum (SC), excellent biocompatibility, simple preparation process, high patient compliance, and minimal invasion. Most importantly, MNs can provide not only efficient and rarely painful delivery carriers, but also combine multi-model strategies with photothermal therapy (PTT), immunotherapy, and gene therapy for synergistic efficacy. To promote an in-depth understanding of their superiorities, this paper systematically summarized the latest application progress of MNs in the treatment of SST by delivering various types of photosensitizers, immune signal molecules, genes, and chemotherapy drugs. Just as important, the advantages, limitations, and drug release mechanisms of MNs based on different materials are introduced in the paper. In addition, the application of MN technology to clinical practice is the ultimate goal of all the work. The obstacles and possible difficulties in expanding the production of MNs and achieving clinical transformation are briefly discussed in this paper. To be anticipated, our work will provide new insights into the precise and rarely painful treatment of SST in the future. Graphical Abstract

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“…Microneedle (MN) technology has emerged as a new drug delivery strategy with great potential to improve the patient compliance [10,11], which has been used for cosmetic [12,13], vaccine [14,15], diagnostic [16,17], or therapeutic applications including diabetes treatment [18,19]. Usually, microneedles (MNs) are placed in an array with microscale in dimension to allow for penetration of the skin barrier.…”

Section: Introductionmentioning

confidence: 99%

Integration of metformin-loaded MIL-100(Fe) into hydrogel microneedles for prolonged regulation of blood glucose levels

Feng,

Li,

Sun

et al. 2024

Biomed. Phys. Eng. Express

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The transdermal drug delivery based on microneedles (MNs) provides a suitable and painless self-administration for diabetic patients. In this work, the hydrogel-forming MNs were firstly fabricated using PVA and chitosan (CS) as matrix. A hypoglycemic drug, metformin (Met), had been loaded into MIL-100(Fe). Then, both of free Met and Met-loaded MIL-100(Fe) were integrated into hydrogel-forming MNs for regulation of BGLs on diabetic rats. After penetrated into the skin, the free Met could be firstly released from MNs. Due to the absorption of interstitial fluid and subsequent release of loaded Met from MIL-100(Fe), leading to a sustainable and long-term drug release behaviors. In vivo experiments performed on diabetic rat models yield a notable hypoglycemic effect and low risk of hypoglycemia. Therefore, MIL-100(Fe) microspheres loaded with Met have good mechanical properties, high drug loading capacity and significant hypoglycemic effect. It is expected to become a new type of transdermal microsphere drug delivery system.

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Microneedles-mediated drug delivery system for the diagnosis and treatment of melanoma

Cited by 11 publications

References 160 publications

Microneedles for in situ tissue regeneration

Microneedles for in situ tissue regeneration

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Integration of metformin-loaded MIL-100(Fe) into hydrogel microneedles for prolonged regulation of blood glucose levels

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