Microneedles with Intrinsic Immunoadjuvant Properties: Microfabrication, Protein Stability, and Modulated Release

Andrianov, Alexander K.; Marin, Alexander; DeCollibus, Daniel P.

doi:10.1007/s11095-010-0133-7

Cited by 41 publications

(24 citation statements)

References 27 publications

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“…Consequently, thermal and mechanical properties of PPZ greatly vary with T g ranging from −10 to 35 °C, contact angle 63°-107°, tensile strength 2.4-7.6 MPa, and modulus of elasticity 31.4-455.9 MPa [264]. PPZ are fabricated into particles, micelles, microneedle coatings, and gels for the delivery of anti-inflammatory drugs, chemotherapeutics, growth factors, DNA, proteins, and vaccines [265][266][267][268]. Moreover, PPZ scaffolds composed of films, fibers, and microspheres are used to assist nerve regeneration and orthopedic applications, alone or blended with polyesters to increase mechanical strength and provide a moderate pH microenvironment for developing tissues [269][270][271].…”

Section: Polyphosphazenesmentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Section: Polyphosphazenesmentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…Andrianov et al reported that the thermal stability of protein and its ability to withstand extreme manufacturing conditions were higher when the protein was in a solution of PCPP coated on solid microneedles as compared to aqueous solution. [36] Modulated protein release was observed from microneedles because of the ion-complexing property of PCPP along with salts of multivalent ions, such as calcium chloride and spermine.…”

Section: Materials Used To Constitute Microneedlesmentioning

confidence: 99%

“…[18] An aqueous polymeric blend was filled in the moulds to fabricate microneedles. Polymeric microneedles can also be fabricated using casting, [36] injection moulding and hot embossing. [18] Chen et al presented a robust Gas-jet coating method to achieve uniform coating of a range of immunotherapeutics, like antigens, DNA and proteins, on microneedles.…”

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2012

Journal of Pharmacy and Pharmacology

357

207

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Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum. Microneedles deliver the drug into the epidermis without disruption of nerve endings. Recent advances in the development of microneedles are discussed in this review for the benefit of young scientists and to promote research in the area. Key findings Microneedles are fabricated using a microelectromechanical system employing silicon, metals, polymers or polysaccharides. Solid coated microneedles can be used to pierce the superficial skin layer followed by delivery of the drug. Advances in microneedle research led to development of dissolvable/degradable and hollow microneedles to deliver drugs at a higher dose and to engineer drug release. Iontophoresis, sonophoresis and electrophoresis can be used to modify drug delivery when used in concern with hollow microneedles. Microneedles can be used to deliver macromolecules such as insulin, growth hormones, immunobiologicals, proteins and peptides. Microneedles containing 'cosmeceuticals' are currently available to treat acne, pigmentation, scars and wrinkles, as well as for skin tone improvement. Summary Literature survey and patents filled revealed that microneedle-based drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional transdermal techniques.

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“…Further in vivo studies with these formulations will research the ability of these systems controlled-release pDNA expression. But the results showed that the total number of positive expression was less than solution prescription in 24 h. However, due to the design, the drug can only be loaded onto the surface of MNs, so the drug loading amount is relatively low [23][24][25]. The cost of fabrication is also another concern.…”

Section: Problems Of Non-hydrogel Mnsmentioning

confidence: 99%

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

et al. 2014

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Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding mechanisms. In recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology.

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Microneedles with Intrinsic Immunoadjuvant Properties: Microfabrication, Protein Stability, and Modulated Release

Abstract: Microneedles containing PCPP coatings provide improved protein stability, modulated release, and protein-friendly microfabrication process.

Cited by 41 publications

References 27 publications

Biodegradable polymers for dental tissue engineering and regeneration

Biodegradable polymers for dental tissue engineering and regeneration

Microneedles: an emerging transdermal drug delivery system

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

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