Microneedling: A Review and Practical Guide

Alster, Tina S.; Graham, Paul M.

doi:10.1097/dss.0000000000001248

Cited by 162 publications

(134 citation statements)

References 33 publications

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“…Prior to MN collagen-induction therapy, patients should use a cleanser to remove any makeup or debris prior to application of any topical aesthetic cream/gel to treatment area (Alster and Graham 2018). Alster and Graham (2018) typically apply a compounded 30% lidocaine cream for 20-30 min before removal with water-soaked gauze and alcohol prep immediately before therapy. In the healthy patient without contraindication to treatment, typical post-procedural expectations in collagen induction therapy with MNs include: pinpoint bleeding, bruising, erythema, and irritation (Fernandes 2005).…”

Section: Adverse Events and Preventionmentioning

confidence: 99%

Dermatotoxicology of microneedles (MNs) in man

Cary

Maibach

2019

Biomed Microdevices

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Developed within the last few decades, microneedles (MNs) have only recently seen wide-scale use among the general population, especially in the area of cosmetics. With the FDA only starting to regulate microneedling devices and the many new microneedling products that enter the modern global market, it is of utmost importance to establish the safety profile and reasonable expectations of the microneedling practice and its products. In our review of current literature, the authors searched the keyword Bmicroneedle^with the following terms: Bsafety^, Bside effect^, Btoxicology^, Badverse effect^, Badverse event^, Binfection^, Bdermatitis^, Bgranuloma^, Bscarring^, and Bhyperpigmentation^. Despite wide-scale implementation of MNs, we are likely only beginning to understand the potential of MNs as a medical and consumer product, and we should, therefore, be aware of any potential adverse events associated with the product.

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Section: Adverse Events and Preventionmentioning

confidence: 99%

Dermatotoxicology of microneedles (MNs) in man

Cary

Maibach

2019

Biomed Microdevices

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“…Multiple technologies including laser, high-intensity focused ultrasound, and radiofrequency (RF) have been developed in an attempt to meet this rising demand. 1 – 8 RF technology has steadily gained popularity since the early 2000s, with consecutive increases annually of 10% or more. 9 , 10 These gains encompass aesthetic surgery and numerous nonaesthetic applications (tissue electrodissection, cardiac catheter ablation, ophthalmic surgery, etc).…”

Section: Introductionmentioning

confidence: 99%

Multimodal Radiofrequency Application for Lower Face and Neck Laxity

Dayan

Riccio²,

Aston

et al. 2020

Plastic and Reconstructive Surgery - Global Open

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Background: Nonexcisional facial skin tightening has long been an elusive goal in aesthetic surgery. The “treatment gap” includes cases who are not “severe” enough for excisions surgery but not “mild” enough for most traditional noninvasive aesthetic modalities. In this retrospective review, we present the largest evaluation to date of radiofrequency (RF) skin tightening technology combination including bipolar RF (FaceTite; InMode) and fractional bipolar RF (Fractora modified to Morpheus8; InMode). Methods: A multicenter retrospective study was conducted between January 2013 and December 2018 using a combination of bipolar RF and fractional bipolar RF for the treatment of facial aging. Data collection included demographic information, Baker Face/Neck Classification, amount of energy used, adverse events, and patient satisfaction. Four cadaver dissections were also conducted to correlate the underlying neuromuscular anatomy with RF treatment of the lower face and neck. Results: Two hundred forty-seven patients (234 women and 13 men) were included in the study. Average age was 55.1 years (SD, ±8), body mass index was 24.3 (±2.4), and 9% (23/247) of patients were active smokers at the time of treatment. Patients had an average Baker Face/Neck Classification score of 3.1 (SD, ±1.4). The procedure was performed under local anesthesia in 240/247 cases (97.2%). Patients objectively improved their Baker Face/Neck Classification score by 1.4 points (SD, ±1.1). Ninety-three percent of patients indicated that they were pleased with their results and would undergo the procedure again. Complications recorded for our cohort included prolonged swelling >6 weeks (4.8%, 12/247), hardened area >12 weeks (3.2%, 8/247), and marginal mandibular neuropraxia (1.2%, 3/247), which all resolved without further intervention. When considering possible control variables, age seems to be a significant factor. That is, older patients were more likely to benefit from a larger magnitude of the treatment effect (as demonstrated by a decrease in the Baker rating from pre- to posttreatment) when compared with younger patients. However, both groups did demonstrate significant improvements across time. Conclusion: While this combination RF treatment (FaceTite bipolar RF and fractional bipolar RF) does not aim to replace a facelift/necklift in appropriate candidates, it does broaden the plastic surgeons’ armamentarium to potentially fill a treatment gap.

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“…Multiple sessions with MN are generally required to get desired results. A 50% to 70% improvement in acne scars was reported as a result of 3-5 sessions of MN at 2-to 4-week intervals (Alster & Graham, 2018). Four sessions of i-PRF and MN + i-PRF were performed at 10-day intervals in this present study; considering the current MN literature, total collagen production during the wound-healing process peaked within 7-14 days (Hakkinen, Larjava, & Koivisto, 2012); in addition, the PRF resorption time was 7-11 days, and growth factor release from i-PRF occurred at 10 days .…”

Section: Discussionmentioning

confidence: 99%

Injectable platelet‐rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial

Özsağir

Sağlam²,

Yılmaz

et al. 2020

J Clinic Periodontology

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Aim The aim of this present study was to evaluate the effect of gingival thickness (GT) and keratinized tissue width (KTW) using injectable platelet‐rich fibrin (i‐PRF) alone and with microneedling (MN) in individuals with thin periodontal phenotypes. Materials and Methods In this split‐mouth study, 33 systemically healthy patients with thin periodontal phenotypes were randomly treated with MN + i‐PRF and i‐PRF. I‐PRF was injected on one side, and MN + i‐PRF was performed on the other side of the same patient at 4 sessions with 10‐day intervals. Clinical periodontal measurements, GT and KTW were assessed before the treatment and every month for six months after the final injection. Results After the evaluation of GT between the groups, a statistically significant difference was found in MN + i‐PRF group at the sixth month. In the intra‐group comparisons, a statistically significant increase in GT was observed within both i‐PRF [from 0.43 mm ± 0.14 to 0.62 mm ± 0.11 (p < .001)] and MN + i‐PRF [from 0.4 mm ± 0.14 to 0.66 mm ± 0.12 (p < .001)] groups at the sixth month. Conclusions In individuals with thin periodontal phenotypes, standalone i‐PRF and i‐PRF with MN may have an influence in increasing GT. The results suggest that application of i‐PRF and MN may be a first step of non‐surgical method for increasing gingival thickness.

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Microneedling: A Review and Practical Guide

Cited by 162 publications

References 33 publications

Dermatotoxicology of microneedles (MNs) in man

Dermatotoxicology of microneedles (MNs) in man

Multimodal Radiofrequency Application for Lower Face and Neck Laxity

Injectable platelet‐rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial

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