Microneedling for Hair Loss

Gupta, Aditya K.; Quinlan, Emma M; Venkataraman, Maanasa; Bamimore, Mary A

doi:10.1111/jocd.14525

Cited by 25 publications

(21 citation statements)

References 47 publications

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“…MN therapy is seen as one advancement of the traditional treatment modality for AGA patients. There are already several evidences showed that MN therapy is effective in AGA to a certain degree, such as the results of a 12‐week randomized, comparative, evaluator‐blinded study on 94 male AGA patients reported by Dhurat et al 14 These results were also confirmed by other researchers, suggesting the effectiveness of MN therapy combined with other established AGA treatments, especially with topical minoxidil 9,11,15–17 . In the present study, our results demonstrated an improvement on cosmetic coverage over the scalp with minimal side effects after MN alongside with minoxidil in AGA patients, which was confirmed by the IGAS based on global photographs, PGAS and patient's final satisfaction.…”

Section: Discussionsupporting

confidence: 87%

“…effectiveness of MN therapy combined with other established AGA treatments, especially with topical minoxidil. 9,11,[15][16][17] In the present study, our results demonstrated an improvement on cosmetic coverage over the scalp with minimal side effects after MN alongside with minoxidil in AGA patients, which was confirmed by the IGAS based on global photographs, PGAS and patient's final satisfaction. However, controversy about the optimal parameters still remains in MN plus minoxidil for AGA, including the types of microneedle devices, needle length, the intervals between the sessions and the number of sessions.…”

Section: F I G U R E 1 Flow Diagram the Chart Shows Patients Inclusio...supporting

confidence: 72%

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Effects of microneedling with 5% minoxidil topical solution combination therapy in treatment of androgenetic alopecia

Jia

Xiong

Guo

et al. 2022

J of Cosmetic Dermatology

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Androgenic alopecia (AGA), known as pattern hair loss, is a common condition in clinical practice, which is characterized by the shortened anagen phase, leading to progressive miniaturizations of hair follicles. It was reported that AGA affects up to 80% of males and approximately 50% of females. 1 This condition was not only associated with appearance, but also related to a significant psycho-social impact. 2 There has also been an increasing demand among the AGA patients to seek treatment for preventing hair loss as well as regaining new hair. Currently, non-surgical interventions mainly include medications, platelet-rich plasma (PRP) injection, microneedling

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Section: Discussionsupporting

confidence: 87%

Section: F I G U R E 1 Flow Diagram the Chart Shows Patients Inclusio...supporting

confidence: 72%

Effects of microneedling with 5% minoxidil topical solution combination therapy in treatment of androgenetic alopecia

Jia

Xiong

Guo

et al. 2022

J of Cosmetic Dermatology

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“…Several theories have been proposed regarding the mechanism of action of microneedling, namely, the induction of Wnt proteins that regulate DP (dermal papilla) signaling to HFSCs (hair follicle stem cells), increased blood ow to the hair follicles, increased scalp metabolism of minoxidil, and increased absorption of topical treatments [23]. While many clinical trials have studied the effectiveness of microneedling in treating AGA, they are often small, nonrandomized, and have varying methodologies, making it di cult to compare results.…”

Section: 3: Microneedling E Cacymentioning

confidence: 99%

Efficacy of Combinational Therapy Using Topical Minoxidil and Microneedling for The Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis

Abdi

Awad

Anthony

et al. 2023

Preprint

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Androgenetic alopecia is a widespread condition that is the most common type of hair loss affecting approximately 58% and 40% of men and women by the age of 50, respectively. Patients have been known to experience severe distress due to androgenetic alopecia, including anxiety, low self-esteem, and depression. The objective of this study was to conduct a systematic review and meta-analysis to determine the efficacy of combination therapy using topical minoxidil and microneedling compared to topical minoxidil alone. This systematic review of randomized controlled trials was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42023391164). The literature search was performed using Scopus, Cochrane, Embase, and the National Institutes of Health's United States National Library of Medicine from inception through January 20, 2022. Randomized controlled trials examining the efficacy of combinational therapy and monotherapy using microneedling and minoxidil on patients with clinically diagnosed androgenetic alopecia were included after screening titles, abstracts, and full texts. Two independent reviewers selected studies, extracted data, and appraised the risk of bias using the Cochrane risk of bias assessment tool. Ten randomized controlled trials, including 466 patients, were selected for this review and eight studies were ultimately included in the meta-analysis. All eight studies displayed a statistically significant increase in total hair count (standard mean difference [SMD], 1.76; 95% CI, 1.26-2.26; P<0.00001); however, the evidence did not support a statistically significant increase in hair diameter (SMD, 0.82; 95% CI, -0.01–1.65; P=0.05). No scarring nor serious adverse events were reported in any of the studies. The findings of this meta-analysis strongly support the utilization of a multimodal therapeutic approach of minoxidil and microneedling for hair growth in patients with androgenetic alopecia. However, variations in factors such as rating scale measurements, microneedling methods, and areas of treatment may have resulted in confounding. Further randomized controlled, large-sample trials employing rigorous methodologies are needed to gain a more comprehensive understanding regarding treatment efficacy, namely the impact of combinational therapy on hair diameter.

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“…Minoxidil, finasteride, and low-level laser light therapy (LLLT) are FDA-approved therapy options for AGA, with a significant effect [45][46][47][48][49][50][51][52]. In addition, dutasteride [41,53], platelet-rich plasma (PRP) [54][55][56], photobiomodulation [50], and microneedling [57] are further treatment options for AGA. However, these treatment options are costintensive and also require lifelong treatment, thus may have side effects.…”

Section: Tcm Understanding Of Hair Lossmentioning

confidence: 99%

Traditional Chinese Medicine Treatment for Androgenetic Alopecia Based on Animal Experiments: A Systematic Review and Meta-Analysis

Liang

Yuan

Shazada

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. In the present study, we systematically evaluated the effects of Traditional Chinese Medicine (TCM) on androgenetic alopecia (AGA) in rodent models (rats and mice) to provide potential evidence for the treatment of AGA by TCM. Methods. Previous research papers focusing on the treatment of AGA by TCM were retrieved from various electronic databases (PubMed, Embase, The Cochrane Library, CNKI, Vip, Wanfang data, and CBM) up to October 30, 2021. Screening of the literature was performed independently, and data were extracted and assessed. A meta-analysis was performed using RevMan 5.3 software. Results. When compared with the model groups, a group of C57BL/6 mice treated with TCM showed an increase in the total number of hair follicles (mean difference [MD] = 11.99, 95% confidence interval [CI] [5.94,18.03], P = 0.0001 ), as well as a decrease in serum testosterone (T) level (MD = −1.10, 95% CI [−1.43, −0.78], P < 0.00001 ), skin discoloration time (MD = −2.93, 95% CI [−4.03, −1.84], P < 0.00001 ), and skin hair growth time (MD = −3.16, 95% CI [−4.16, −2.16], P < 0.00001 ). Terminal hair/vellus hair also increased in TCM-treated AGA animals (MD = 3.02, 95% CI [2.05, 3.98], P < 0.00001 ). No significant difference was found in serum estradiol (E2) level, skin tissue E2 level, or skin tissue T level between the TCM-treated group and the model group. Conclusion. TCM can increase the total number of hair follicles and terminal hair/vellus hair ratio, and reduce skin discoloration time and skin hair growth time in AGA animal models. These effects may be related to the reduction of the serum T level in AGA animals. These conclusions need to be verified by high-quality studies as the current analysis may be affected by the number and quality of the studies identified.

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Microneedling for Hair Loss

Cited by 25 publications

References 47 publications

Effects of microneedling with 5% minoxidil topical solution combination therapy in treatment of androgenetic alopecia

Effects of microneedling with 5% minoxidil topical solution combination therapy in treatment of androgenetic alopecia

Efficacy of Combinational Therapy Using Topical Minoxidil and Microneedling for The Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis

Traditional Chinese Medicine Treatment for Androgenetic Alopecia Based on Animal Experiments: A Systematic Review and Meta-Analysis

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