Microneedling with injectable platelet-rich fibrin for facial rejuvenation

Abstract

Aim:The aim of this literature review is to evaluate the efficacy of microneedling treatment with injectable plateletrich fibrin (i-PRF) for facial skin rejuvenation applications, using an objective skin analysis system and validated patient-reported outcome measures. Methods:The search approach involved the exploration of electronic databases. An advanced search option was applied to filter our search line, i.e., from February 2011 to April 2021. We performed a search on Medline, Scopus, Embase, and Web of Science, while improving the accessed articles via Ovid interface. Our keywords were chiefly aligned with a combination of MeSH terms and text words. All retrieved articles were written in English. Results:The search yielded 73 studies. After reviewing their title and summary, nine of them were found to meet the inclusion criteria and, next, the full-text articles were reviewed. Of these, three studies were excluded from systematic research, as they would no longer meet the inclusion criteria. In total, six studies were considered for review. Conclusion:Microneedling treatments combined with blood concentrates are increasingly being utilized as autologous products for aesthetic purposes. Few works can be found on i-PRF in facial rejuvenation, and even fewer on i-PRF along with microneedling. Combined applications seem to be promising and minimally invasive. Further

Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial

“…Growth factor binding and platelet capture are facilitated via the three-dimensional fibrin structure of PRF that results in the enhancement of the gradual and long-term release of cytokines and growth factors. Moreover, this fibrin mesh is also responsible for cell proliferation and differentiation and the formation of new blood vessels [ 11 , 12 ]. Finally, PRF prompts cell proliferation, migration, differentiation, and adhesion accompanied by anti-inflammatory properties that further support its therapeutic aptitude in bone regeneration, wound healing, improving scar appearance, and stimulating hair growth [ 2 , 13 ].…”

“…In addition, these platelet aggregate products contain cell adhesion proteins PRF, the second generation of platelet concentrates, is superior to PRP in numerous aspects. First of all, PRF preparation consists of only one centrifugation step, making it simpler than PRP preparation [12]. As a result of declined centrifuge speed, PRF has been observed to contain higher volumes of growth factors, leukocytes, fibrin, and platelets than PRP, resulting in a more boosted growth factor-mediated functional aftermath [11].…”

A Split-Face Study to Evaluate Efficacy of Autologous Injectable Platelet-Rich Fibrin With Microneedling Against Microneedling With Normal Saline (Placebo Control) in Atrophic Acne Scars

“…The morphology of i-PRF is retained for more than 10 days. 12,13 The lower adjustment of the relative centrifugation force (RCF) while preparing PRF matrices increases platelet (with meaningfully higher concentrations of major growth factors) and White Blood Cells counts in the resultant PRF matrix to a great extent. [14][15][16][17] The lower RCF protocol (60 g) and higher RCF protocol (208 g) generate 2 different types of matrices.…”

“…[14][15][16][17] The lower RCF protocol (60 g) and higher RCF protocol (208 g) generate 2 different types of matrices. 12 In the authors' study, the authors used the low RCF protocol.…”

Effectiveness of Injectable Platelet-Rich Fibrin Therapy in Alopecia and Facial Rejuvenation: A Systematic Review

“…The growth factors in PRF are known to stimulate collagen production, which is crucial in maintaining skin elasticity and strength, thereby potentially reducing wrinkles and improving skin texture [8,9]. Clinical trials and cohort studies have shown promising results in using PRF for facial esthetic improvements, including reducing the appearance of wrinkles and fine lines [10,11]. Despite these promising applications, the evidence is still emerging, and the mechanisms by which PRF exerts its effects still need to be fully understood.…”