Microneurographic recording from unmyelinated nerve fibers in neurological disorders: An update

Donadio, Vincenzo; Liguori, Rocco

doi:10.1016/j.clinph.2014.10.009

Cited by 30 publications

(20 citation statements)

References 63 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another approach to identifying peripheral contributions to pain is microneurography, which permits direct recording of unmyelinated nerve via tungsten needles inserted into a peripheral nerve fascicle. 20 Serra and colleagues have demonstrated abnormal activity of C nociceptors among patients with fibromyalgia and patients with neuropathic pain. 73, 74 Thus, skin biopsy and microneurography represent existing techniques that may be incorporated into future assessment protocols to provide information regarding peripheral mechanisms contributing to clinical pain.…”

Section: Assessment Of Pain Mechanismsmentioning

confidence: 99%

Assessment of Chronic Pain: Domains, Methods, and Mechanisms

Fillingim

Loeser

Baron

et al. 2016

The Journal of Pain

294

225

View full text Add to dashboard Cite

Accurate classification of chronic pain conditions requires reliable and valid pain assessment. Moreover, pain assessment serves several additional functions, including documenting severity of the pain condition, tracking the longitudinal course of pain, and providing mechanistic information. Thorough pain assessment must address multiple domains of pain, including the sensory and affective qualities of pain, temporal dimensions of pain, and the location and bodily distribution of pain. Where possible, pain assessment should also incorporate methods to identify pathophysiological mechanisms underlying the pain. This article discusses assessment of chronic pain, including approaches available for assessing multiple pain domains and for addressing pathophysiological mechanisms. We conclude with recommendations for optimal pain assessment.

show abstract

Section: Assessment Of Pain Mechanismsmentioning

confidence: 99%

Assessment of Chronic Pain: Domains, Methods, and Mechanisms

Fillingim

Loeser

Baron

et al. 2016

The Journal of Pain

294

225

View full text Add to dashboard Cite

show abstract

“…Microneurography is used to record the activity of C‐nociceptors and sympathetic fibers and to test the efficacy of different compounds in blocking abnormal on‐going activity in both animal models and in patients . The use of microneurography is increasing in disorders affecting the peripheral nervous system . However, its application in clinical practice remains limited due to the technical challenges, the amount of time needed to perform the examination, the small number of nerve fibers that can be studied in any given patient, and the test awaits validation of diagnostic value…”

Section: Epidemiologymentioning

confidence: 99%

“…85 The use of microneurography is increasing in disorders affecting the peripheral nervous system. [86][87][88][89] However, its application in clinical practice remains limited due to the technical challenges, the amount of time needed to perform the examination, the small number of nerve fibers that can be studied in any given patient, and the test awaits validation of diagnostic value. 90…”

Section: Microneurographymentioning

confidence: 99%

Small‐fiber neuropathy: Expanding the clinical pain universe

Sopacua

Hoeijmakers

Merkies

et al. 2019

J Peripheral Nervous Sys

104

View full text Add to dashboard Cite

Small‐fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to a significant reduction in quality of life. According to international criteria, the diagnosis is established by the assessment of intraepidermal nerve fiber density and/or quantitative sensory testing. SFN is mainly associated with autoimmune diseases, sodium channel gene variants, diabetes mellitus, and vitamin B12 deficiencies, although in more than one half of patients no etiology can be identified. Recently, gain‐of‐function variants in the genes encoding for the Nav1.7, Nav1.8 and Nav1.9 sodium channel subunits have been discovered in SFN patients, enlarging the spectrum of underlying conditions. Sodium channel gene variants associated with SFN can lead to a diversity of phenotypes, including different pain distributions and presence or absence of autonomic symptoms. This suggests that SFN is part of a clinical continuum. New assessments might contribute to a better understanding of the cellular and molecular substrates of SFN and might provide improved diagnostic methods and trial designs in the future. Identification of the underlying mechanisms may inform the development of drugs that more effectively address neuropathic pain and autonomic symptoms of SFN.

show abstract

“…The needle electrodes used in microneurography allow reliable recordings from unmyelinated C-fibers in humans. Through intricate manipulation, the needle tip can penetrate the endoneurium to be in close proximity with C-type axons so as to achieve reliable extracellular recordings [6, 20, 21]. Micro lesions of recorded axons have been documented in some microneurographic recordings, indicative of its potential risk [22].…”

Section: Introductionmentioning

confidence: 99%

In vitro multichannel single-unit recordings of action potentials from the mouse sciatic nerve

Chen

Ilham

Guo

et al. 2017

Biomed. Phys. Eng. Express

View full text Add to dashboard Cite

Electrode arrays interfacing with peripheral nerves are essential for neuromodulation devices targeting peripheral organs to relieve symptoms. To modulate (i.e., single-unit recording and stimulating) individual peripheral nerve axons remains a technical challenge. Here, we report an in vitro setup to allow simultaneous single-unit recordings from multiple mouse sciatic nerve axons. The sciatic nerve (~30 mm) was harvested and transferred to a tissue chamber, the ~5mm distal end pulled into an adjacent recording chamber filled with paraffin oil. A custom-built multi-wire electrode array was used to interface with split fine nerve filaments. Single-unit action potentials were evoked by electrical stimulation and recorded from 186 axons, of which 49.5% were classed A-type with conduction velocities (CV) greater than 1 m/s and 50.5% were C-type (CV < 1 m/s). The single-unit recordings had no apparent bias towards A- or C-type axons, were robust and repeatable for over 60 minutes, and thus an ideal opportunity to assess different neuromodulation strategies targeting peripheral nerves. For instance, ultrasonic modulation of action potential transmission was assessed using the setup, indicating increased nerve conduction velocity following ultrasound stimulus. This setup can also be used to objectively assess the design of next-generation electrode arrays interfacing with peripheral nerves.

show abstract

Microneurographic recording from unmyelinated nerve fibers in neurological disorders: An update

Cited by 30 publications

References 63 publications

Assessment of Chronic Pain: Domains, Methods, and Mechanisms

Assessment of Chronic Pain: Domains, Methods, and Mechanisms

Small‐fiber neuropathy: Expanding the clinical pain universe

In vitro multichannel single-unit recordings of action potentials from the mouse sciatic nerve

Contact Info

Product

Resources

About