Micronization of chitosan via rapid expansion of supercritical solution

Ghoreishi, S.M.; Hedayati, Ali; Kordnejad, Morteza

doi:10.1016/j.supflu.2016.01.005

Cited by 30 publications

(13 citation statements)

References 40 publications

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“…With supercritical fluid extraction (SFE), SC-CO2 can be easily recycled and the usage of organic solvents is prevented. Several advantages of SFE including the low viscosity, high diffusivity allowing easy penetration into the smallest pores of particles, high solubility, no surface tension and variable solvent strength make this method the most attractive and suitable technology over the conventional extraction methods [11,12].…”

Section: Introductionmentioning

confidence: 99%

Experimental investigation and optimization of supercritical carbon dioxide extraction of toxic heavy metals from solid waste using different modifiers and chelating agents

Ghoreishi

Hedayati

Ansari

2016

The Journal of Supercritical Fluids

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Section: Introductionmentioning

confidence: 99%

Experimental investigation and optimization of supercritical carbon dioxide extraction of toxic heavy metals from solid waste using different modifiers and chelating agents

Ghoreishi

Hedayati

Ansari

2016

The Journal of Supercritical Fluids

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“…supercritical anti-solvent, supercritical assisted atomization or rapid expansion of supercritical solution) have been used to obtain nanoparticles containing chitosan. [23][24][25][26] Although there are reports about the use of simple scCO 2 drying procedures to obtain Cs materials with different sizes and morphologies, such as monolith and microparticles, 27,28 none of these materials is at the nanoscale. Usually, the materials obtained by scCO 2 drying have the large specic surface area, low density and mesoporous structure, providing appealing properties for diverse applications, including active transport of bioactive substances.…”

Section: 21mentioning

confidence: 99%

Supercritical CO₂dried chitosan nanoparticles: production and characterization

et al. 2017

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Herein are reported the production and characteristics of chitosan nanoparticles that go through supercritical CO 2 drying. First, chitosan nanoparticles in aqueous colloidal suspension were produced by ionic crosslinking with sodium tripolyphosphate. The produced nanoparticles have a surface charge (z-potential) of +27 mV and an average diameter of approximately 100 nm, measured by dynamic light scattering and field emissionscanning electron microscopy observations. The liquid phase of the nanoparticle suspension was replaced successively with ethanol and supercritical CO 2 to produce dried chitosan nanoparticles finally. The main characteristics of the obtained nanoparticles were determined by diverse analytical techniques. Infrared spectroscopy, solid-state 13 C nuclear magnetic resonance and X-ray diffraction studies were performed to explore possible physicochemical changes induced by the drying procedure. Also, the thermal stability of the dry chitosan nanoparticles was determined by thermogravimetric assay and dynamic scanning calorimetry.Structural properties were analyzed and compared with lyophilized nanoparticles finding that the supercritically dried chitosan nanoparticles have a surface area an order of magnitude higher. Microscopy images showed that the supercritically dried chitosan nanoparticles have a porous conglomerated structure, suggesting that there is particle aggregation through the drying process. Notwithstanding, the dry chitosan nanoparticles resuspended in the dilute acid medium readily; microscopy observations showed that the size of the resuspended particles remains in the nanoscale range. The proposed procedure is able to furnish dried chitosan nanoparticles with structural characteristics and functional properties that are appealing for their use in diverse applications.

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“…The objective is to understand the interaction among various parameters and the optimization of the operating conditions to obtain the best response, simultaneously 19 . RSM is a useful tool which has been widely applied successfully in several fields for the optimization of operating parameters in various processes [20][21][22] .…”

Section: Fig 4: the Flow Sheet Of The Electrothermal Fluidized Bed Cmentioning

confidence: 99%

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2017

IJPSR

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Zirconium tetrachloride was produced in a pilot plant fluidized bed reactor via the carbochlorination reaction of zirconia. Minitab software 17 was used for the design of experiment with response surface methodology (RSM) for both semi batch and continuous processes. The operating temperature (800-1200 °C), reaction time (30-90 min) and mean particle size (MPS) (70-130µm) were chosen as the range of operating conditions at semi-batch mode. Also, the ranges of operating variables at the continuous mode were chosen to be the operating temperature(1000-1400°C), chlorine concentration (3-5mol/m 3 ) and mean particle size (MPS) (70-130µm). The coefficients of determination (R 2 ) for semi-batch and continuous modes by RSM analysis were 99.54% and 99.94%, respectively. The optimal operating conditions was predicted to be the Cl 2 concentration of 3mol/m 3 , temperature of 1380 °C and the mean particle size of 70µm in which the maximum chlorine conversion of 98.26% was obtained at continuous process. The optimum operating conditions for semi-batch process were found by using RSM modelling to be 1200°C, 90 min and 70 µm, in which the maximum zirconia conversion of 92.7% was obtained.

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Micronization of chitosan via rapid expansion of supercritical solution

Cited by 30 publications

References 40 publications

Experimental investigation and optimization of supercritical carbon dioxide extraction of toxic heavy metals from solid waste using different modifiers and chelating agents

Experimental investigation and optimization of supercritical carbon dioxide extraction of toxic heavy metals from solid waste using different modifiers and chelating agents

Supercritical CO₂dried chitosan nanoparticles: production and characterization

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Micronization of chitosan via rapid expansion of supercritical solution

Cited by 30 publications

References 40 publications

Experimental investigation and optimization of supercritical carbon dioxide extraction of toxic heavy metals from solid waste using different modifiers and chelating agents

Experimental investigation and optimization of supercritical carbon dioxide extraction of toxic heavy metals from solid waste using different modifiers and chelating agents

Supercritical CO2dried chitosan nanoparticles: production and characterization

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Supercritical CO₂dried chitosan nanoparticles: production and characterization