Micronization of Magnolia Bark Extract with Enhanced Dissolution Behavior by Rapid Expansion of Supercritical Solution

He, Shuai; Zhang, Zhongyi; Xu, Feng; Zhang, Shouyao; Lei, Zhengjie

doi:10.1248/cpb.58.154

Cited by 11 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with the above inhibitors, magnolol has the advantages of abundant sources and easy preparation 26 , 27 . The high hydrophobicity and low solubility of magnolol may be the major obstacles to its bioavailability and clinical efficacy 28 , 29 . However, we revealed that the concentrations required to restore antimicrobial activity could be achieved in bacteria.…”

Section: Discussionmentioning

confidence: 99%

Magnolol restores the activity of meropenem against NDM-1-producing Escherichia coli by inhibiting the activity of metallo-beta-lactamase

Shui

Zhou

Niu

et al. 2018

Cell Death Discovery

View full text Add to dashboard Cite

The emergence of plasmid-mediated New Delhi metallo-β-lactamase-1 (NDM-1) in carbapenem-resistant Gramnegative pathogens is an increasing clinical threat. Here we report the discovery of an NDM-1 inhibitor, magnolol, through enzyme inhibition screening. We showed that magnolol significantly inhibited NDM enzyme activity (IC 50 = 6.47 µg/mL), and it restored the activity of meropenem against Escherichia coli ZC-YN3, an NDM-1-producing E. coli isolate, in in vitro antibacterial activity assays. Magnolol lacked direct antibacterial activity, but compared with meropenem alone, it reduced the MICs of meropenem against E. coli ZC-YN3 by 4-fold and killed almost all the bacteria within 3 h. Molecular modeling and a mutational analysis demonstrated that magnolol binds directly to the catalytic pocket (residues 110 to 200) of NDM-1, thereby blocking the binding of the substrate to NDM-1 and leading to its inactivation. Our results demonstrate that the combination of magnolol and meropenem may have the potential to treat infections caused by NDM-1-positive, carbapenem-resistant Gram-negative pathogens.

show abstract

Section: Discussionmentioning

confidence: 99%

Magnolol restores the activity of meropenem against NDM-1-producing Escherichia coli by inhibiting the activity of metallo-beta-lactamase

Shui

Zhou

Niu

et al. 2018

Cell Death Discovery

View full text Add to dashboard Cite

show abstract

“…However, many Chinese medicinal material extracts have poor solubility Molecular Pharmaceutics ARTICLE or slow dissolution rate, which may reduce tissue absorption and therapeutic potency upon administration. 27 With these therapeutic inadequacies, many efforts have been made to design new drug carrier systems that are able to improve the drug's solubility and stability in vivo, while retaining its therapeutic efficacy. To increase its solubility and bioavailability, attempts have been made through encapsulation using liposomes 28 and cyclodextrin.…”

Section: ' Introductionmentioning

confidence: 99%

“…To increase its solubility and bioavailability, attempts have been made through encapsulation using liposomes 28 and cyclodextrin. 27 Traditional liposomal drug carriers are limited by low drug encapsulation efficiency, poor storage stability, rapid clearance from the bloodstream, nonspecific uptake by the mononuclear phagocytic system, poor control over release of the drug from the liposome and rapid drug loss profiles in vivo. 29,30 Thus, colloidal drug carriers based on biodegradable polymers have received great attention recently for local release of drug toward the arterial wall.…”

Section: ' Introductionmentioning

confidence: 99%

“…Despite extensive research and development on magnolol-based investigations, relatively poor solubility of magnolol, being highly hydrophobic in nature, in aqueous solution remains a major hurdle over its bioavailability and clinical efficacy. However, many Chinese medicinal material extracts have poor solubility or slow dissolution rate, which may reduce tissue absorption and therapeutic potency upon administration …”

Section: Introductionmentioning

confidence: 99%

“…With these therapeutic inadequacies, many efforts have been made to design new drug carrier systems that are able to improve the drug’s solubility and stability in vivo, while retaining its therapeutic efficacy. To increase its solubility and bioavailability, attempts have been made through encapsulation using liposomes and cyclodextrin . Traditional liposomal drug carriers are limited by low drug encapsulation efficiency, poor storage stability, rapid clearance from the bloodstream, nonspecific uptake by the mononuclear phagocytic system, poor control over release of the drug from the liposome and rapid drug loss profiles in vivo. , Thus, colloidal drug carriers based on biodegradable polymers have received great attention recently for local release of drug toward the arterial wall. , Among polymeric nanoparticulate materials, hydrogel nanoparticles have been the point of convergence of a considerable amount of effort devoted to the study of these systems dealing with drug delivery approaches.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Magnolol-Loaded Core–Shell Hydrogel Nanoparticles: Drug Release, Intracellular Uptake, and Controlled Cytotoxicity for the Inhibition of Migration of Vascular Smooth Muscle Cells

Wang

Chien²,

et al. 2011

Mol. Pharmaceutics

View full text Add to dashboard Cite

Encapsulation and release behavior of a water-insoluble drug, magnolol, using a core-shell polysaccharide-based nanoparticle, manipulating the cellular internalization and controlled cytotoxic effect of magnolol-loaded nanoparticles over the A10 vascular smooth muscle cells (VSMCs) was reported. A magnolol-polyvinylpyrrolidone (PVP) core phase was prepared, followed encapsulating by an amphiphilic carboxymethyl-hexanoyl chitosan (CHC) shell to form a magnolol-loaded core-shell hydrogel nanoparticles (termed magnolol-CHC nanoparticles). The resulting magnolol-CHC nanoparticles were employed for evaluation of drug release and controlled cytotoxic inhibition of VSMCs migration in vitro. A sustained release of the magnolol from the nanoparticles was determined. The magnolol-CHC nanoparticles exhibited outstanding cellular uptake efficiency, and under a cytotoxic evaluation, an increased antiproliferative effect and effective inhibition of VSMC migration as a result of efficient intracellular delivery of the encapsulated magnolol in comparison to free magnolol was achieved. We then envision a potential intracellular medication strategy with improved biological and therapeutic efficacy using the magnolol-CHC nanoparticles illustrated in this work.

show abstract

Green Chromatography

2012

Handbook of Green Analytical Chemistry

View full text Add to dashboard Cite

Greening the university laboratories 3.2Green laboratory experiments 3.2.1Green methods for sample pretreatment 3.2.2 Green separation using liquid-liquid, solid-phase and solventiess extractions 3.2.3Green alternatives for chemical reactions 3.2.4Green spectroscopy 3.3The place of Green Analytical Chemistry in the future of our laboratories References vi Contents 4 Publishing in Green Analytical Chemistry 55 Salvador G'arrigues and Miguel de la Guardia 4.1 A bibliometric study of the literature in Green Analytical Chemistry 56 4.2 Milestones of the literature on Green Analytical Chemistry 57 4.

show abstract

Micronization of Magnolia Bark Extract with Enhanced Dissolution Behavior by Rapid Expansion of Supercritical Solution

Cited by 11 publications

References 17 publications

Magnolol restores the activity of meropenem against NDM-1-producing Escherichia coli by inhibiting the activity of metallo-beta-lactamase

Magnolol restores the activity of meropenem against NDM-1-producing Escherichia coli by inhibiting the activity of metallo-beta-lactamase

Magnolol-Loaded Core–Shell Hydrogel Nanoparticles: Drug Release, Intracellular Uptake, and Controlled Cytotoxicity for the Inhibition of Migration of Vascular Smooth Muscle Cells

Green Chromatography

Contact Info

Product

Resources

About