Micronodular Kaposi’s Sarcoma – A New Variant of Classic-Sporadic Kaposi’s Sarcoma

Abstract

Kaposi’s sarcoma (KS) in its classic-sporadic form is a rare vascular neoplasm affecting predominantly elderly men of Jewish or Mediterranean origin. Women are very rarely affected by KS. The tumor manifests itself most commonly with brownish macular or infiltrated oval lesions on the lower legs in both genders. Human herpesvirus 8 (HHV-8) has recently been demonstrated to be etiologically linked to KS. We report a 51-year-old HIV-seronegative Caucasian woman with an unusual, previously not described variant of KS which presented with small (3 mm in diameter) scattered firm red papules on her right arm. The histology with nodular spindle cell tumor expressing endothelial markers, the demonstration of serum antibodies against HHV-8 and the presence of viral nucleic acids in the lesional tissue proved the diagnosis of the nodular stage of KS. An indolent course characterized by clinically identical seasonal recurrences, even after surgical treatment and cryosurgery, was observed during the follow-up period of 9 years. We propose the term ‘micronodular KS’ for this unusual clinical variant of KS mimicking capillary hemangioma.

Histological Subgroups in Classic Kaposi Sarcoma

“…PBS ile y›kand› ve protein blokaj› sonras›nda primer antikor ile ile oda s›cakl›¤›nda 1 saat inkübe edildi. S›ras›yla sekonder antikor, streptavidin peroksidaz kompleksi ve renklendirmek icin 6,[9][10][11][12][13][14][15][16] . En s›k görülen his- …”

“…Bu grupta yer alan olgular›n %26,4'ü makül, %37,6's› plak ve %36's› nodüler evre lezyonlard›r. Serimizde olgular›n %17,2'si histopatolojik özellikleri aç›s›n-dan literatürde tan›mlanan alt tipler ile uyum göstermekte-dir 6,[9][10][11][12][13][14][15][16] . En s›k görülen histolojik alt tip lenfanjiyektatik varyant (%7,3) olup, bunu s›ras›yla büllöz (%2,6), lenfanjiyom benzeri (%2,6), intravasküler (%2) ve piyojenik granülom benzeri (%2) varyantlar izlemektedir.…”

“…Tüm olgularda HHV8 immünreaktivitesi gösterilmifltir. ‹lk olarak 2004 y›l›nda Kempf ve ark., taraf›ndan tan›mlanan mikronodüler KS; retiküler dermiste küçük, iyi s›n›rl› i¤si hücre proliferasyonu ile karakterizedir 14 . Çap› genellikle 3 mm'den küçüktür.…”

“…Çap› genellikle 3 mm'den küçüktür. Literatürde çok az say›da olgu bildirilmifltir 6,14 . Bildirilen kütanöz yerleflimli tek olgu klasik KS olan bir kad›n hastad›r 14 .…”

“…Literatürde çok az say›da olgu bildirilmifltir 6,14 . Bildirilen kütanöz yerleflimli tek olgu klasik KS olan bir kad›n hastad›r 14 . Mayaud ve ark., ise AIDS hastalar›nda plevral ve bronflial yerleflimli benzer lezyonlar tan›mlam›fllard›r 15 .…”