2019
DOI: 10.4103/njs.njs_10_18
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Micronuclei in exfoliated cells: A biomarker of genotoxicity in tobacco users

Abstract: Aims: The aim of this study was to analyze the tobacco-related genotoxic effects in individual with habit of smoking and chewing tobacco. Materials and Methods: The present study sample consisted of 120 individuals attending the outpatient department of D. J. College of Dental Sciences and Research, Modinagar, Uttar Pradesh (UP). The sample was divided into four groups as follows: Group I (individuals with habit of smoking tobacco), Group II (individuals with habit of c… Show more

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Cited by 18 publications
(3 citation statements)
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“…The micronuclear assay is widely employed as a valuable biomarker in studies pertaining to genomic instability, genotoxic exposure, and initial biological response in human biomonitoring endeavors. The elicitation of MN is a highly efficient biomarker for diseases and phenomena linked to the elicitation of DNA damage [ 11 ]. Ceppi et al reported a significant association between the frequency of MN in exfoliated buccal cells and the frequency of MN in lymphocytes.…”
Section: Discussionmentioning
confidence: 99%
“…The micronuclear assay is widely employed as a valuable biomarker in studies pertaining to genomic instability, genotoxic exposure, and initial biological response in human biomonitoring endeavors. The elicitation of MN is a highly efficient biomarker for diseases and phenomena linked to the elicitation of DNA damage [ 11 ]. Ceppi et al reported a significant association between the frequency of MN in exfoliated buccal cells and the frequency of MN in lymphocytes.…”
Section: Discussionmentioning
confidence: 99%
“…To determine the required minimum sample size, we utilized the sample size effect (Cohen’s d), derived from Upadhyay et al [ 27 ]. Based on the difference in micronuclei occurrence in buccal mucosa cells between non-smokers (1.03 ± 1.27) and smokers (7.58 ± 5.67), the sample size effect (Cohen’s d) was calculated as 1.594.…”
Section: Methodsmentioning
confidence: 99%
“…It is one of the important organelles that determines the shape of the cell, ensures its integrity, controls its interaction with external objects, regulates the metabolism and energy exchange between the cell and the environment. At the same time, the integrity of the membrane is determined not only by the integrity of its geometric shape, but also by the unity (relationship) of its various functional characteristics, in particular, the relationship of chemical 6 , physicochemical 7 , physiological 8,9 , as well as physical 10,11 excitation mechanisms. The latter largely determine the mechanical properties of living cells.…”
mentioning
confidence: 99%