Micronutrient Deficiencies in Patients with Decompensated Liver Cirrhosis

Llibre-Nieto, Gemma; Lira, Alba; Vergara, Mercedes; Solé, Cristina; Casas, Meritxell; Puig-Diví, Valentí; Solé, Gemma; Humanes, Antònia; Grau, Laia; Barradas, Josep Maria; Miquel, Mireia; Sánchez-Delgado, Jordi

doi:10.3390/nu13041249

Cited by 33 publications

(21 citation statements)

References 45 publications

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“…Llibre-Nieto et al noted about 85% prevalence of zinc deficiency; however, none were identified with B12 deficiency similar to our study. Studies have particularly shown that patients in Child-Pugh B or C are at a higher risk of developing zinc deficiency as well as other nutrient and caloric deficits [ 7 , 8 , 10 ]. Overall, there are no set guidelines to date that suggest checking for or monitoring patients with cirrhosis for micronutrient deficiencies in the outpatient setting.…”

Section: Discussionmentioning

confidence: 99%

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Nutritional Deficiencies and Clinical Practices in Decompensated Cirrhotics With Hepatic Encephalopathy

Panchani¹,

Colvin²,

Aryan³

et al. 2022

Cureus

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Background Hepatic encephalopathy (HE), a major complication of end-stage cirrhosis, is often associated with nutritional deficiencies. We aimed to assess the frequency in which vitamins and zinc were tested for and deficient in our cirrhotic population with HE. Methods We performed a retrospective chart review of 143 patients with decompensated cirrhosis that were seen in a hepatology clinic from January 2020 to May 2021. Patient demographics and decompensations were recorded. Vitamins and minerals that were evaluated included zinc, vitamin B12, folate, vitamin D, and thiamine. Continuous variables were reported as mean ± standard deviation and categorical variables were calculated as frequency percentages. Results Out of 143 patients, 73 were found to have HE. Out of 73, 33 were male, and the average MELD was 15.5 ± 6.3. 44% of patients had NASH cirrhosis, and 30% had alcoholic cirrhosis. Of the minority of patients that had their nutrient levels checked, 17/23 (74%) were deficient in zinc (<60 mcg/dL). 75% of patients were deficient in thiamine. 2/34 (6%) were deficient in folate (<5.9 ng/mL), 2/10 (20%) in vitamin D (<20 ng/mL), and 2/47 (4%) in B12 (<300 pg/mL). Conclusion Nutritional deficiencies are common in cirrhotics with HE. Further studies are needed to determine if routine testing and treatment for vitamin and Zinc deficiencies would have a positive impact on the clinical trajectory of HE.

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Section: Discussionmentioning

confidence: 99%

“…Several studies have looked at micronutrient deficiencies in liver cirrhosis and methods of effectively identifying those patients that may be at higher risk of these losses [ 7 , 8 ]. Some studies have also shown that educating patients and obtaining appropriate nutritional counseling helped in reducing admissions [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Deficiencies and Clinical Practices in Decompensated Cirrhotics With Hepatic Encephalopathy

Panchani¹,

Colvin²,

Aryan³

et al. 2022

Cureus

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“…Megaloblastic anemia can occur secondary to a micronutrient vitamin B 12 or folate deficiency. 4 , 5 , 6 In patients who consume large quantities of alcohol to the exclusion of more nutritious food may develop nutrient deficiencies. Folate and vitamin B 12 deficiencies impair hematopoiesis and primarily cause a decrease in number of RBCs.…”

Section: Questions/discussion Points Partmentioning

confidence: 99%

Educational Case: Evaluating a patient with cirrhosis

2022

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“…Tỷ lệ thiếu calci, sắt và phospho tương ứng là 4,6%; 38,8% và 34,4%; có 12,8% bệnh nhân có tình trạng thiếu hụt magie. 6…”

Section: Kết Quảunclassified

Tình trạng thiếu vi chất dinh dưỡng ở trẻ mắc bệnh gan mạn tính tại Bệnh viện Nhi Trung ương

Linh¹,

Hoa²,

Hồng³

2023

TCNCYH

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Trẻ em mắc bệnh gan mạn tính có nhiều nguy cơ bị suy dinh dưỡng, đặc biệt thiếu các vi khoáng chất. Nghiên cứu mô tả trên 154 trẻ mắc bệnh gan mạn tính đang điều trị tại Bệnh viện Nhi Trung ương để khảo sát tình trạng thiếu hụt một số vi chất dinh dưỡng. Số trẻ nữ chiếm 54,5% và trẻ nam chiếm 45,5%. Tuổi trung vị của nghiên cứu là 21 tháng. Nhóm tuổi từ 0 - 5 tuổi chiếm tỷ lệ cao nhất (77,9%). Nguyên nhân hay gặp nhất gây bệnh gan mạn tính là teo mật bẩm sinh chiếm 76%. Các vi khoáng chất thiếu hụt với tỷ lệ khác nhau: kẽm (72,7%), vitamin K (37%) và vitamin D (27,9%). Tỷ lệ thiếu hụt sắt, phospho, magie, canxi thấp hơn, lần lượt là 26,1%, 22,6%, 10% và 2,2%. Nhóm nguyên nhân teo mật bẩm sinh có tỷ lệ thiếu hụt vitamin D phổ biến nhất, lên tới 61,1%. Tình trạng thiếu các vi chất dinh dưỡng nói chung phổ biến nhất ở nhóm trẻ dưới 5 tuổi.

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Micronutrient Deficiencies in Patients with Decompensated Liver Cirrhosis

Cited by 33 publications

References 45 publications

Nutritional Deficiencies and Clinical Practices in Decompensated Cirrhotics With Hepatic Encephalopathy

Nutritional Deficiencies and Clinical Practices in Decompensated Cirrhotics With Hepatic Encephalopathy

Educational Case: Evaluating a patient with cirrhosis

Tình trạng thiếu vi chất dinh dưỡng ở trẻ mắc bệnh gan mạn tính tại Bệnh viện Nhi Trung ương

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