Micronutrient Supplementation and Clinical Outcomes in Patients with Dengue Fever

Langerman, Steven; Ververs, Mija

doi:10.4269/ajtmh.20-0731

Cited by 6 publications

(7 citation statements)

References 30 publications

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“…In a recent review article, 17 Langerman SD and colleagues have concluded the same way. 18 So, the role of micronutrients in developing dengue and its related complications still needs to be explored in randomized controlled trials. This is a small sample study, which limited its impacts.…”

Section: Discussionmentioning

confidence: 99%

Cytopenia in dengue fever and their associations: A Cohort Study

Zehra,

Aamir,

Nasreen

et al. 2024

JSTMU

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Introduction: Dengue fever is endemic in countries like Pakistan and has multiple complications. Leukopenia and thrombocytopenia are common cytopenia that sometimes lead to complex outcomes. So, we considered it essential to find the associations of dengue-related cytopenia and planned this study. Methodology: An observational, retrospective cohort study was conducted at Shifa International Hospital Islamabad. 125 patients from the inpatient department diagnosed with dengue fever based on clinical presentation and positive dengue non-structural protein 1 (NS1) were enrolled. Their vitamin B12 levels, minimum values of TLC (total leukocyte count), and platelet counts during admission were found in their records. All information was entered and analyzed using the SPSS 23 version. After descriptive statistics, Patients' age, gender, residence, and B12 levels were cross tabulated against the TLC and platelet count values using the chi-square test. The descriptive results were expressed in percentages, while chi-square was described as a p < 0.05, considered statistically significant. Results: 125 patients with dengue fever were included in the study; 73 (58.4%) were male, and 52 (41.6%) were female. The mean age was 42.8, the mean B12 level was 94.3 pmol/L, the mean platelet count was 57,000/ µL, and the mean TLC was 5084.8/ µL. Age, gender, residence, and B12 levels did not affect leukopenia and thrombocytopenia in dengue patients (p > 0.05). Conclusion: Dengue-related cytopenia is not correlated with the differences in age, gender, residence and B12 levels and mandates further research work.

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Section: Discussionmentioning

confidence: 99%

Cytopenia in dengue fever and their associations: A Cohort Study

Zehra,

Aamir,

Nasreen

et al. 2024

JSTMU

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“…The possible role of vitamin D in DENV infection has been suggested by several studies [ 12 , 13 , 14 , 15 , 17 , 30 ], both in terms of its deficiency as a potential risk factor for developing severe dengue illness [ 31 , 32 , 33 ] and as possible adjuvant in the treatment of dengue patients [ 12 , 13 , 15 , 34 , 35 ]. Acute high dose vitamin D is believed to help in DF symptoms improvement and reduce the likelihood of progression to DHF/DSS.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency (VDD) and Susceptibility towards Severe Dengue Fever—A Prospective Cross-Sectional Study of Hospitalized Dengue Fever Patients from Lahore, Pakistan

et al. 2023

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Dengue is a mosquito-borne flaviviral serious febrile illness, most common in the tropical and subtropical regions including Pakistan. Vitamin D is a strong immunomodulator affecting both the innate and adaptive immune responses and plays a pivotal role in pathogen-defense mechanisms. There has been considerable interest in the possible role of vitamin D in dengue viral (DENV) infection. In the present prospective cross-sectional study, we assessed a possible association between serum vitamin D deficiency (VDD) and susceptibility towards severe dengue fever (DF) illness. Serum vitamin D levels were measured at the time of hospitalization in 97 patients diagnosed with dengue fever (DF), dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) at Mayo Hospital, King Edward Medical University, Lahore, PK, from 16 November 2021 to 15 January 2022. In terms of disease severity, 37 (38.1%) patients were DF, 52 (53.6%) were DHF grade 1 and 2, and 8 (8.2%) were DSS. The results revealed that most patients (75 (77.3%)) were vitamin-D-deficient (i.e., serum level < 20 ng/mL), including 27 (73.0%) in DF, 41 (78.8%) in DHF grade 1 and 2, and 7 (87.5%) in DSS. The degree of VDD was somewhat higher in DSS patients as compared to DF and DHF grade 1 and 2 patients. Overall, serum vitamin D levels ranged from 4.2 to 109.7 ng/mL, and the median (IQR) was in the VDD range, i.e., 12.2 (9.1, 17.8) ng/mL. Our results suggest that there may be a possible association between VDD and susceptibility towards severe dengue illness. Hence, maintaining sufficient vitamin D levels in the body either through diet or supplementation may help provide adequate immune protection against severe dengue fever illness. Further research is warranted.

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“…Vitamin D affects both the innate and adaptive immune responses through several mechanisms, including T-cell activation, macrophage differentiation, and the production of anti-microbial peptides such as cathelicidin (LL-37) and β-defensin. It also influences the expression of the DENV entry receptor, dendritic cell-specific intercellular adhesion molecule-grabbing non-integrin (DC-SIGN), and FCγRIIA in immune cells (Langerman & Ververs, 2021). Vitamin D inhibits Th-1 cell proliferation with decreased production of interferon-gamma and interleukin-2.…”

Section: Role Of Vitamin D In Dengue Viral Illnessmentioning

confidence: 99%

Role of Serum Vitamin D Level in the Progression of Dengue Viral Illness: A Potential Immunomodulator?: A Literature Review

Limbu,

Chaudhary,

Jha

2024

J. Multidisc. Res. Adv.

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This is a literature review on the role of serum vitamin D levels in dengue viral illness as a potential immunomodulator. The dengue virus is an RNA virus that causes many symptoms, from asymptomatic phases to severe forms like dengue hemorrhagic fever and dengue shock syndrome. The review methodology was based on evidence-based rapid review, and the review's objectives are to scrutinize all the available articles on dengue virus and vitamin D from standard databases and literature searches. It was found that there are no specific antivirals for the definitive management of the dengue virus, and vitamin D, with its potential antiviral and immunomodulatory effects, can play a significant role against the dengue viral illness. It was also found that there are limited reviews on the association between dengue virus and vitamin D. The review concludes that there is a possible association between supplementing with vitamin D and lowering the risk of progression to severe dengue viral illness and that regular testing of serum vitamin D levels is highly encouraged during the illness as vitamin D levels get depleted with the progression of the illness.

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Micronutrient Supplementation and Clinical Outcomes in Patients with Dengue Fever

Cited by 6 publications

References 30 publications

Cytopenia in dengue fever and their associations: A Cohort Study

Cytopenia in dengue fever and their associations: A Cohort Study

Vitamin D Deficiency (VDD) and Susceptibility towards Severe Dengue Fever—A Prospective Cross-Sectional Study of Hospitalized Dengue Fever Patients from Lahore, Pakistan

Role of Serum Vitamin D Level in the Progression of Dengue Viral Illness: A Potential Immunomodulator?: A Literature Review

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