Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; Bertoncin, Paolo; Janssens, Barbara; Barba, Anna Angela

doi:10.1039/c9ra03022k

Cited by 34 publications

(22 citation statements)

References 46 publications

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“…In that regard, in a work of Dalmoro and coworkers (2019), polymer–lipid hybrid nanoparticles, encapsulating vitamin D3 and vitamin K2, with improved features in terms of stability, loading, and mucoadhesiveness, were produced for potential nutraceutical and pharmaceutical applications. The work, which concerns the production of liposomes coated with chitosan, is deepened in the next section in terms of the innovativeness of the production technique presented [ 46 ].…”

Section: Polymeric Lipid and Hybrid Nanostructuresmentioning

confidence: 99%

“…This novel method has been applied for covering nanoliposomes containing indomethacin as the active ingredient, obtaining nanoliposomes characterized by high loading and drug encapsulation efficiency, with a chitosan layer thicker and smoother than that achievable by the dropwise method [ 45 ]. Moreover, by the same technology, stable and mucoadhesive chitosan-coated liposomal carriers, loaded with vitamin D3 and K2, were produced for nutraceutical purpose [ 46 ]. Finally, in 2019, the novel simil-microfluidic technique was used to produce a vegan alternative formulation composed of cholesterol-free liposomes coated by guar hydroxypropyltrimonium chloride (Guar-HC) obtaining stable mucoadhesive carrier systems without aggregation phenomena [ 90 ].…”

Section: Innovations and Performances Of Production Technologiesmentioning

confidence: 99%

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Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

Bochicchio¹,

Lamberti

Barba

2021

Pharmaceutics

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Some issues in pharmaceutical therapies such as instability, poor membrane permeability, and bioavailability of drugs can be solved by the design of suitable delivery systems based on the combination of two pillar classes of ingredients: polymers and lipids. At the same time, modern technologies are required to overcome production limitations (low productivity, high energy consumption, expensive setup, long process times) to pass at the industrial level. In this paper, a summary of applications of polymeric and lipid materials combined as nanostructures (hybrid nanocarriers) is reported. Then, recent techniques adopted in the production of hybrid nanoparticles are discussed, highlighting limitations still present that hold back the industrial implementation.

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Section: Polymeric Lipid and Hybrid Nanostructuresmentioning

confidence: 99%

Section: Innovations and Performances Of Production Technologiesmentioning

confidence: 99%

Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

Bochicchio¹,

Lamberti

Barba

2021

Pharmaceutics

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“…For each formulation, unloaded liposomes control samples were also prepared for comparison. Through the described method, vitamin D3-and K2-loaded vesicles were previously produced for potential nutraceutical and pharmaceutical applications as described in a precedent work [40], while vitamin E and curcumin nanoliposomes were explored for the first time. recovering/homogenizing tank (from [38], published by The Royal Society of Chemistry).…”

Section: Manufacturing Techniquementioning

confidence: 99%

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Bochicchio¹,

Dalmoro

Simone

et al. 2020

Cosmetics

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Novel nanotechnologies represent the most attractive and innovative tools to date exploited by cosmetic companies to improve the effectiveness of their formulations. In this context, nanoliposomes have had a great impact in topical preparations and dermocosmetics, allowing the transcutaneous penetration and absorption of several active ingredients and improving the stability of sensitive molecules. Despite the recent boom of this class of delivery systems, their industrial production is still limited by the lack of easily scalable production techniques. In this work, nanoliposomes for the topical administration of vitamin D3, K2, E, and curcumin, molecules with high antioxidant and skin curative properties but unstable and poorly absorbable, were produced through a novel simil-microfluidic technique. The developed high-yield semi continuous method is proposed as an alternative to face the problems linked with low productive conventional methods in order to produce antioxidant formulations with improved features. The novel technique has allowed to obtain a massive production of stable antioxidant vesicles of an 84–145 nm size range, negatively charged, and characterized by high loads and encapsulation efficiencies. The obtained products as well as the developed high-performance technology make the achieved formulations very interesting for potential topical applications in the cosmetics/cosmeceutical field.

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“…All performed characterizations demonstrate that that coated (vegan or not) liposomes are ideal candidates for the controlled release of various ingredients. For example, chitosan coated liposomes-encapsulating nutraceuticals, with improved features in terms of stability, loading and mucoadhesiveness-have already been produced [10].…”

Section: Characterization Of Coated Nanolipid Structuresmentioning

confidence: 99%

“…The coating process of vesicles by chitosan is largely studied and applied, but it is essentially based on drop-wise bulk methods, leading to small product output volumes, which are not useful for industrial purposes. Therefore, an innovative continuous method based on microfluidic principles was previously developed to produce chitosan covered nanoliposomes [2] that also encapsulating nutraceuticals [10]. Moreover, the trial and error approach is usually used to detect the best concentration for coating vesicles by chitosan.…”

Section: Introductionmentioning

confidence: 99%

Coating of Nanolipid Structures by a Novel Simil-Microfluidic Technique: Experimental and Theoretical Approaches

Barba

Bochicchio²,

Bertoncin

et al. 2019

Coatings

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Nanolipid vesicular structures are ideal candidates for the controlled release of various ingredients, from vitamins for nutraceutical purposes to chemoterapic drugs. To improve their stability, permeability, and some specific surface properties, such as mucoadhesiveness, these structures can require a process of surface engineering. The interaction of lipid vesicles with oppositely charged polyelectrolytes seems to be an interesting solution, especially when the negatively charged liposomes are complexed with the cationic chitosan. In this work, a novel simil-microfluidic technique was used to produce both chitosan-coated vesicles and a vegan alternative composed of cholesterol-free liposomes coated by Guar Hydroxypropyltrimonium Chloride (Guar-HC). The combination between the experimental approach, based on experimental observations in terms of Z-potential, and size evolutions, and the theoretical approach, based on concepts of saturation, was the methodology applied to define the best polycation concentration to fairly cover (vegan or not) liposomes without aggregation. The smart production of coated nanolipid structures was confirmed by characterizations of morphology, mucoadhesiveness, and stability.

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Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

Abstract: Micronutrients administration by liposomal vectors is a growing strategy in fortification processes of staple and complementary foods to fight malnutrition and micronutrient deficiencies and related pathologies.

Cited by 34 publications

References 46 publications

Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Coating of Nanolipid Structures by a Novel Simil-Microfluidic Technique: Experimental and Theoretical Approaches

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