Micronutrients in African-Americans with decompensated and compensated heart failure

Arroyo, M.; LaGuardia, S. P.; Bhattacharya, Syamal K.; Nelson, M. D.; Johnson, Patti L.; Carbone, Laura D; Newman, Kevin P.; Weber, Karl T.

doi:10.1016/j.trsl.2006.08.003

Cited by 65 publications

(58 citation statements)

References 55 publications

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“…PTH levels were not increased in AfricanAmericans with compensated, treated failure or in non-heart failure patients serving as controls. 29,30 Calculated creatinine clearance ranged between 60 ml/min to 90 ml/min in these African-American patients with either decompensated or compensated heart failure and therefore, marked renal failure (creatinine clearance <30 ml/min) which is accompanied by secondary hyperparathyroidism, does not account for the appearance of secondary hyperparathyroidism. The importance of our findings is further supported by recently published interventional studies with nutrients.…”

Section: Chf: a Salt-avid Statementioning

confidence: 93%

Congestive Heart Failure is a Systemic Illness: A Role for Minerals and Micronutrients

Alsafwah¹,

LaGuardia²,

Arroyo³

et al. 2007

Clinical Medicine & Research

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Congestive heart failure (CHF) is a clinical syndrome that features a failing heart together with signs and symptoms arising from renal retention of salt and water, mediated by attendant neurohormonal activation, and which prominently includes the renin-angiotensin-aldosterone system. More than this cardiorenal perspective, CHF is accompanied by a systemic illness whose features include an altered redox state in diverse tissues and blood, an immunostimulatory state with proinflammatory cytokines and activated lymphocytes and monocytes, and a wasting of tissues that includes muscle and bone. Based on experimental studies of aldosteronism and clinical findings in patients with CHF, there is an emerging body of evidence that secondary hyperparathyroidism is a covariant of CHF. The aldosteronism of CHF predisposes patients to secondary hyperparathyroidism because of a chronic increase in Ca 2+ and Mg 2+ losses in urine and feces, with a fall in their serum ionized levels and consequent secretion of parathyroid hormone. Secondary hyperparathyroidism accounts for bone resorption and contributes to a fall in bone strength that can lead to nontraumatic fractures. The long-term use of a loop diuretic with its attendant urinary wasting of Ca 2+ and Mg 2+ further predisposes patients to secondary hyperparathyroidism and attendant bone loss. Aberrations in minerals and micronutrient homeostasis that includes Ca 2+ , Mg 2+ , vitamin D, zinc and selenium appear to be an integral component of pathophysiologic expressions of CHF that contributes to its systemic and progressive nature. This broader perspective of CHF, which focuses on the importance of secondary hyperparathyroidism and minerals and micronutrients, raises the prospect that dietary supplements could prove remedial in combination with the current standard of care.

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Section: Chf: a Salt-avid Statementioning

confidence: 93%

Congestive Heart Failure is a Systemic Illness: A Role for Minerals and Micronutrients

Alsafwah¹,

LaGuardia²,

Arroyo³

et al. 2007

Clinical Medicine & Research

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“…Two further studies among African Americans also showed a high prevalence of vitamin D deficiency in patients with heart failure [84,85]. Interestingly, not all heart-failure patients with vitamin D deficiency show elevations in PTH levels but those with secondary hyperparathyroidism have more severe forms of heart failure [83][84][85]. In a cohort of over 3000 patients referred for coronary angiography 25(OH)D as well as 1,25(OH)D were inversely correlated with left ventricular dysfunction, New York Heart Association functional class and N-terminal pro-B type natriuretic peptide (NT-pro-BNP) [86].…”

Section: Vitamin D Deficiency and Heart Failure In Adultsmentioning

confidence: 98%

“…In a study among 102 African Americans, vitamin D deficiency was observed in 84-96% of heart-failure patients, whereas only one-third of the healthy controls was vitamin D deficient [83]. Two further studies among African Americans also showed a high prevalence of vitamin D deficiency in patients with heart failure [84,85]. Interestingly, not all heart-failure patients with vitamin D deficiency show elevations in PTH levels but those with secondary hyperparathyroidism have more severe forms of heart failure [83][84][85].…”

Section: Vitamin D Deficiency and Heart Failure In Adultsmentioning

confidence: 99%

Vitamin D deficiency and myocardial diseases

Pilz

Tomaschitz

Drechsler

et al. 2010

Molecular Nutrition Food Res

135

142

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Vitamin D deficiency is common among patients with myocardial diseases because sun-induced vitamin D production in the skin and dietary intake of vitamin D is often insufficient. Knockout mice for the vitamin D receptor develop myocardial hypertrophy and dysfunction. It has also been shown that children with rickets who suffered from severe heart failure could be successfully treated with supplementation of vitamin D plus calcium. In adults, almost all patients with heart failure exhibit reduced 25-hydroxyvitamin D levels, which are used to classify the vitamin D status. In prospective studies, vitamin D deficiency was an independent risk factor for mortality, deaths due to heart failure and sudden cardiac death. Several vitamin D effects on the electrophysiology, contractility, and structure of the heart suggest that vitamin D deficiency might be a causal factor for myocardial diseases. Data from interventional trials, however, are rare and urgently needed to elucidate whether vitamin D supplementation is useful for the treatment of myocardial diseases. In our opinion, the current knowledge of the beneficial effects of vitamin D on myocardial and overall health strongly argue for vitamin D supplementation in all vitamin D-deficient patients with or at high risk for myocardial diseases.

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“…Odnos izmeu razine vitamina D te uËestalost i stupanj zatajivanja srca je istraaeena u nekoliko studija [60][61][62][63][64][65][66] . Istraaeivanje na Afroamerikancima koji su bili podijeljeni u tri skupine srËanog zatajivanja nije dokazalo povezanost izmeu koncentracije kalcidiola i stupnja srËanog zatajivanja.…”

Section: Vitamin D I Zatajivanje Srcaunclassified

“…The relation between vitamin D level and incidence and degree of heart failure has been explored in several studies [60][61][62][63][64][65][66] . The trial on African-Americans who were divided into three groups of heart failure has not proven the correlation between the concentration of calcidiol and a degree of heart failure.…”

Section: Vitamin D and Heart Failurementioning

confidence: 99%

Vitamin D and cardiovascular diseases

Josipović¹,

Pavlović²

2014

Cardiol Croat.

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Cardiologia CROATICA UvodKlasiËna uloga vitamina D je poveÊanje apsorpcije kalcija u crijevima . Istraaeivanja su pokazala da manjak vitamina D uzrokuje poveÊanje rizika od razvoja srËanoaeilnih bolesti (SAEB). NaËin na koji vitamin D πtiti pojedinca od SAEB nije do kraja istraaeen. Postoje mnoge teorije, ukljuËujuÊi negativnu regulaciju renina i time sniaeavanje arterijskog tlaka (AT), sniaeavanje razine paratiroidnog hormona (PTH) i poboljπanje kontrole glikemije (Tablica 1). Fiziologija vitamina DVitamin D se pojavljuje u dva oblika: vitamin D2 (ergokalciferol) i vitamin D3 (kolekalciferol). Vitamin D2 koji se nalazi u biljkama i kvascu, proizvod je djelovanja ultraljubiËastih zraka na ergosterol dok se vitamin D3 nalazi u masnoj ribi i ulju dobivenom iz bakalarove jetre te maslacu. Vrlo su male koliËine u mesu, kravljem i ljudskom mlijeku. Vitamin D iz hrane apsorbira se u tankom crijevu ovisno o apsorpciji lipida i hilomikronima prelazi u limfu i u krv te u jetru. OpÊenito se apsorbira 50% vitamina D uneπenog hranom (Slika 1).

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Micronutrients in African-Americans with decompensated and compensated heart failure

Cited by 65 publications

References 55 publications

Congestive Heart Failure is a Systemic Illness: A Role for Minerals and Micronutrients

Congestive Heart Failure is a Systemic Illness: A Role for Minerals and Micronutrients

Vitamin D deficiency and myocardial diseases

Vitamin D and cardiovascular diseases

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