Microorganisms in the Pathogenesis and Management of Anti-phospholipid Syndrome (Hughes Syndrome)

Mendoza‐Pinto, Claudia; Garcı́a-Carrasco, Mario; Cervera, Ricard

doi:10.1007/978-981-19-4800-8_17

Cited by 2 publications

(1 citation statement)

References 65 publications

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“…Anti-phospholipid antibodies are heterogeneous antibodies, present in nearly 2-5% of reproductively-active females [31], 14% of females with recurrent first-trimester abortions [32], and 10% in females with unexplained sub-fertility and recurrent miscarriages [33]. They attack the negativelycharged phospholipids with a phospholipid-binding plasma protein (PLBP) [34].…”

Section: Anti-phospholipid Antibodies (Apas)mentioning

confidence: 99%

Female Autoimmune Disorders with Infertility: A Narrative Review

Hassan

Al-Tuma

2023

amj

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Autoimmunity is a condition in which the immune system cannot recognize the self from nonself-antigens. Autoimmunity is relatively more common in females than males. The process of embryo implantation is considered the most significant restricting factor in female reproduction. The immunological system of the females may affect the success or failure of pregnancy by its effect on extremely important steps from ovulation to implantation processes, thus ensuring the importance of autoimmunity for women in sub-fertility. The association between autoimmunity and female reproduction receives increased attention nowadays. A successful conception is a result of multiple complex interactions between the developed embryo and the receptive uterus and is usually under immune-hormonal control. In certain circumstances, the female ovary can be a target of an autoimmune attack, like some organ-specific or systemic autoimmune disorders subsequently resulting in clinically significant ovarian dysfunction, implantation failure, and sub-fertility. Consequently, the effect of a specific auto-antibody on the etiology of infertility remains unknown. This review focused on auto-antibodies that may affect female fertility.

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Section: Anti-phospholipid Antibodies (Apas)mentioning

confidence: 99%

Female Autoimmune Disorders with Infertility: A Narrative Review

Hassan

Al-Tuma

2023

amj

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Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome

Akinsulie,

Olowu,

Adesola

et al. 2024

Bacteria

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Antiphospholipid syndrome (APS), also known as Hughes syndrome, is a systemic autoimmune disorder characterized by recurrent thrombosis and pregnancy complications, accompanied by the presence of antiphospholipid antibodies (aPLs). These antibodies target anionic phospholipids or protein–phospholipid complexes within cell membranes, contributing to the underlying mechanisms of the disease. Although anticoagulation therapy remains the cornerstone of APS management, it often fails to prevent complications, particularly in obstetric and thrombotic cases. As autoimmune diseases become increasingly linked to alterations in the gut microbiome, this study investigates the complex interaction between gut bacteria and immune modulation in APS. We explore how disruptions in the gut microbiome may influence the development of autoimmune conditions, with a specific focus on APS. By identifying key microorganisms potentially involved in this gut–immune axis, we aim to provide insights into novel preventive and control approaches. Future research should focus on harnessing the gut microbiome to develop more effective treatments that target both the immune system and microbial populations in APS patients.

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Microorganisms in the Pathogenesis and Management of Anti-phospholipid Syndrome (Hughes Syndrome)

Cited by 2 publications

References 65 publications

Female Autoimmune Disorders with Infertility: A Narrative Review

Female Autoimmune Disorders with Infertility: A Narrative Review

Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome

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