Micropapular Tuberculid and Rosacea

Laymon, Carl W.; Schoch, Eugene P.

doi:10.1001/archderm.1948.01520220040004

Cited by 10 publications

(2 citation statements)

References 4 publications

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“…For a long time, LMDF has been regarded as tuberculids caused by tubercle bacilli, because histologic pictures of the lesions of LMDF showed typical tubercles with central caseation. But it has been reported that histologic pictures similar to the central caseation in tuberculosis are recognized in skin lesions other than tuberculids, for example, in the eruptions caused by Demodexfolliculorum (29)(30)(31), acne rosacea (32)(33)(34) and tularemia (35). Fukada (35) reported that the only reliable way to differentiate typical tubercles from so-called pseudotubercles of tularemia was' by means of reticulum fiber stains.…”

Section: Commentmentioning

confidence: 99%

Clinicopathological and Immunological Studies of Lupus Miliaris Disseminatus Faciei

Shitara

1982

The Journal of Dermatology

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Eighty‐one cases of lupus miliaris disseminatus faciei were clinically and histologically studied, and some of them were also immunologically studied. Age at onset, distribution of skin lesions, and incidence by sex did not differ from the reports of various investigators. No apparent increase in incidence of this disease was noted. The histologic features of this disease could be divided into four types. Some relation between pilosebaceous units and epithelioid cell granulomas could be found in the lesions of 35 (43%) out of 81 cases. Central caseation may be coagulation necrosis caused by abscesses. Some immunological data were obtained from this study, but there were no abnormalities in delayed hypersensitivity reactions, e.g. tuberculin test, DNCB skin reaction, PHA skin reaction and the Kveim test, or in quantitative serum immunoglobulin surveys. Lymphocyte transformation tests using two mitogens, PHA‐P and Con‐A, showed normal responses. It was not possible to obtain enough data from the clinical data and histologic findings for this disease to be regarded as a tuberculid. But from the histologic findings, lupus miliaris disseminatus faciei was assumed to be a chronic inflammatory disease of pilosebaceous units and epithelioid cell granulomas in the lesions might be reactions to destroyed hair follicles or epithelial cysts. With these assumptions, the following hypotheses concerning the pathogenesis of this disease were proposed. 1) Epithelial cysts occur and rupture in the dermis for some reason resulting in formation of foreign‐body granulomas which break down epithelial cysts in the dermis. 2) Inflammatory infiltrates occur within the follicular epithelium or sebaceous glands for some reason and they are destroyed resulting in formation of epithelioid cell granulomas to follicular contents, such as keratin, sebum and Demodex folliculorum. Under the above assumptions, I would like to support the theory that lupus miliaris disseminatus faciei is not a tuberculid but a skin disorder similar to the papular type of acne rosacea.

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Section: Commentmentioning

confidence: 99%

Clinicopathological and Immunological Studies of Lupus Miliaris Disseminatus Faciei

Shitara

1982

The Journal of Dermatology

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“…In 1948, Laymon and Schoch proposed that tuberculoid structures could occur in acne rosacea and were not related to the presence of a tuberculid. 11 The granulomata were thought to be a foreign body cell reaction to keratinized cells of disintegrating hair structures. It is now more generally accepted that the causative agent produces lipases which hydrolize sebum to fatty acids, the presence of which then elicits an inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Fine-needle aspiration cytology of acne rosacea

Rollins¹,

Sheets²

2000

Diagn. Cytopathol.

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Acne rosacea is a common dermatologic condition which is usually diagnosed by its clinical presentation. This article describes an unusual presentation of acne rosacea and the diagnosis of this condition using fine‐needle aspiration biopsy. To our knowledge, the fine‐needle aspiration findings of acne rosacea have not been previously described and illustrated in the cytology literature. Diagn. Cytopathol. 23:106–107, 2000. © 2000 Wiley‐Liss, Inc.

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Sarcoidal Reaction to Lymphoma Presenting as Granulomatous Rosacea

Sherertz¹

1986

Arch Dermatol

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A patient with poorly differentiated lymphocytic lymphoma had rosacealike facial lesions noted at the time of diagnosis of the lymphoma. The skin lesions followed the course of exacerbations and remissions of the systemic lymphoma. A biopsy specimen showed a sarcoidal granulomatous inflammation in the skin, and later in subcutaneous nodules that developed on the face. This case is consistent with a sarcoidal tissue reaction to lymphoma, and is unique in its clinical presentation as granulomatous rosacea.

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Micropapular Tuberculid and Rosacea

Cited by 10 publications

References 4 publications

Clinicopathological and Immunological Studies of Lupus Miliaris Disseminatus Faciei

Clinicopathological and Immunological Studies of Lupus Miliaris Disseminatus Faciei

Fine-needle aspiration cytology of acne rosacea

Sarcoidal Reaction to Lymphoma Presenting as Granulomatous Rosacea

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