Microparticle‐ and Nanoparticle‐Based Contrast‐Enhanced Ultrasound Imaging

Deshpande, Nirupama; Willmann, Jürgen K.

doi:10.1002/9780470767047.ch11

Cited by 10 publications

(23 citation statements)

References 70 publications

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“…As briefly described previously, ultrasound contrast agents comprise microbubbles consisting of a gaseous core, stabilized by an outer shell made of lipid, protein, or polymer. 9,15,104,[112][113][114][115] Once introduced into circulation, ultrasound contrast microbubbles interact with the incident ultrasonic beam, which causes them to oscillate and produce an enhanced sound wave that is returned to the transducer. This is due primarily to the large difference in acoustic impedance between the gas inside the contrast microbubble and the surrounding tissue.…”

Section: Analytics Of Kinetic Behaviormentioning

confidence: 99%

Targeted Contrast-Enhanced Ultrasound for Inflammation Detection

Volz

Evans

Kanner

et al. 2016

Journal of Diagnostic Medical Sonography

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Molecular imaging is a form of nanotechnology that enables the noninvasive examination of biological processes in vivo. Radiopharmaceutical agents are used to target biochemical markers, permitting their detection and evaluation. Early visualization of molecular variations indicative of pathophysiological processes can aid in patient diagnoses and management decisions. Molecular imaging is performed by introducing into the body molecular probes, which are often contrast agents that have been nanoengineered to target and tether to molecules, thus enabling their radiologic identification. Through a nanoengineering process, ultrasound contrast agents can be targeted to specific molecules, extending ultrasound's capabilities from the tissue to molecular level. Molecular ultrasound, or targeted contrastenhanced ultrasound (TCEUS), has recently emerged as a popular molecular imaging technique due to its ability to provide real-time anatomic and functional information without ionizing radiation. However, molecular ultrasound represents a novel form of molecular imaging and consequently remains largely preclinical. This review explores the commonalities of TCEUS across several molecular targets and points to the need for standardization of kinetic behavior analysis. The literature underscores evidence gaps and the need for additional research. The application of TCEUS is unlimited but needs further standardization to ensure that future research studies are comparable.

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Section: Analytics Of Kinetic Behaviormentioning

confidence: 99%

Targeted Contrast-Enhanced Ultrasound for Inflammation Detection

Volz

Evans

Kanner

et al. 2016

Journal of Diagnostic Medical Sonography

View full text Add to dashboard Cite

show abstract

“…"It is our belief that the contrast effect represents the ultrasonic detection of miniature bubbles within the heart produced by gaseous cavitation, which occurs when the contrast agent is injected rapidly, or by miniature bubbles injected in the foam of indocyanine-green solutions [67]." This discovery paved the way to an era of numerous designs of micro-and, later, nanobubbles in the following decades that are covered in many reviews and books [68][69][70].…”

Section: Topo-cdmentioning

confidence: 99%

Historical Perspective on Nanoparticles in Imaging from 1895 to 2000

Berezin

2014

Nanotechnology for Biomedical Imaging and Diagnostics

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“…At the seven-minute time point, the burst mechanism was activated, rupturing all microbubbles within the beam profile. 5,12,15,19,31,40,[51][52][53][54] Imaging continued for two more minutes to monitor the effect of the bursting pulse on the contrast distribution at the site of injury. This was done to confirm binding of the US contrast microbubbles to inflammatory biomarkers.…”

Section: Tceusmentioning

confidence: 99%

Exploring Targeted Contrast-Enhanced Ultrasound to Detect Neural Inflammation

Volz

Evans

Kanner

et al. 2016

Journal of Diagnostic Medical Sonography

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Targeted contrast-enhanced ultrasound (TCEUS) is an innovative method of molecular imaging used for detection of inflammatory biomarkers in vivo. By targeting ultrasound contrast to cell adhesion molecules (CAMs), which are known inflammatory markers within neural tissue, a more direct evaluation of neural inflammation can be made. Due to the novel nature of TCEUS, standardized methods of image analysis do not yet exist. Time intensity curve (TIC) shape analysis is currently used in magnetic resonance contrast imaging to determine temporal behavior of perfusion. Therefore, the presented research attempts to determine TIC shape analysis utility in TCEUS imaging by applying it to TCEUS scans targeted to CAMs present in neural inflammation. This was done in an animal model that underwent a traumatic spinal cord injury to induce inflammation ( n = 31). Subjects were divided into four groups, each receiving a TCEUS targeted to a different CAM seven days after surgery (P-selectin, intracellular adhesion molecule 1 [ICAM-1], vascular cell adhesion molecule 1 [VCAM-1], and control). TICs were generated using average pixel intensity within the injured region of the spinal cord. TIC shape analysis found similar curves were produced while targeting P-selectin and VCAM-1, both demonstrating rapid and sustained enhancement. Control injections demonstrated no enhancement. ICAM-1 injections demonstrated limited enhancement and a shape similar to the control.

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Microparticle‐ and Nanoparticle‐Based Contrast‐Enhanced Ultrasound Imaging

Cited by 10 publications

References 70 publications

Targeted Contrast-Enhanced Ultrasound for Inflammation Detection

Targeted Contrast-Enhanced Ultrasound for Inflammation Detection

Historical Perspective on Nanoparticles in Imaging from 1895 to 2000

Exploring Targeted Contrast-Enhanced Ultrasound to Detect Neural Inflammation

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