Micropatterning of inorganic precipitations in hydrogels with soft lithography

Yan, Hui; Zhao, Yongtao; Qiu, Caian; Wu, Hongkai

doi:10.1016/j.snb.2008.01.002

Cited by 12 publications

(12 citation statements)

References 29 publications

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“…Figure a shows a schematic of the procedure for fabricating an array of miniature reactors (see Figure S1 in the Supporting Information for details) 26–29. Briefly, two blocks of polydimethylsiloxane (PDMS) containing cylindrical holes were aligned and stacked on a silicon substrate to form a two‐dimensional array of reactors.…”

Section: Resultsmentioning

confidence: 99%

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On‐Chip Screening of Experimental Conditions for the Synthesis of Noble‐Metal Nanostructures with Different Morphologies

Zhou

Zeng

Grant

et al. 2011

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The applications of nanostructures critically depend on their morphologies. Although significant progress has been made in the chemical synthesis of nanostructures with a variety of different morphologies, it is still highly desired to develop an approach that allows one to quickly identify the best set of parameters for nanostructure syntheses. Herein, an on-chip approach to the rapid screening of experimental conditions pivotal to the production of nanostructures with different morphologies is reported. The key component of this approach is an array of reactors containing solutions with a one- or two-dimensional gradient in reagent concentration, pH value, or reaction temperature. In the proof-of-concept experiments, the parameters needed for the production of Au and Pd nanostructures with various morphologies are quickly identified. In principle, this approach can be extended to other systems for rapid screening and optimization of experimental conditions involved in the syntheses of different types of nanostructures.

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Section: Resultsmentioning

confidence: 99%

“…The PDMS block with an array of completely perforated holes was fabricated using soft lithography as described previously 26, 28. A PDMS prepolymer mixture was poured onto the PDMS mold, and a silicon wafer pretreated with TDFOCS was placed on top of the mixture.…”

Section: Methodsmentioning

confidence: 99%

On‐Chip Screening of Experimental Conditions for the Synthesis of Noble‐Metal Nanostructures with Different Morphologies

Zhou

Zeng

Grant

et al. 2011

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“…Since the architecture and chemical composition of hydrogels can be easily engineered, hydrogels have been utilized for 3D cell culture systems (Hahn et al 2006; Choi et al 2007; Gillette et al 2008; Kloxin et al 2009). The geometry of hydrogels has been controlled by the use of elastic molds (Tang et al 2003; Franzesi et al 2006; Golden and Tien 2007; Yan et al 2008a, b) and photocrosslinkable hydrogels (Koh et al 2002; Arcaute et al 2006; Tsang et al 2007; Panda et al 2008). These patterning techniques have recently been applied to 3D co-culture systems to create in vivo -like culture systems or tissue constructs (Tan and Deasi 2004; Tsang et al 2007; Wong et al 2008; Panda et al 2008; Nichol and Khademhosseini 2009; Sung and Shuler 2009).…”

Section: Introductionmentioning

confidence: 99%

“…The reversibility of hydrogels facilitates tissue engineering (Nelson and Tien 2006), and allows selectively capture and release of cells for further analysis (Plouffe et al 2009). Although several types of hydrogels are thermo-reversible, these hydrogels have mainly been used as 2D scaffolds or as injectable cell carriers (Yan et al 2008a, b; Chen and Cheng 2009). Furthermore, these hydrogels and techniques cannot be applied to ionically cross-linked hydrogels (Franzesi et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Patterning alginate hydrogels using light-directed release of caged calcium in a microfluidic device

Chueh

Zheng

Torisawa

et al. 2009

Biomed Microdevices

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This paper describes a simple reversible hydrogel patterning method for 3D cell culture. Alginate gel is formed in select regions of a microfluidic device through light-triggered release of caged calcium. In the pre-gelled alginate solution, calcium is chelated by DM-nitrophen (DM-n) to prevent cross-linking of alginate. After sufficient UV exposure the caged calcium is released from DM-n causing alginate to cross-link. The effect of using different concentrations of calcium and chelating agents as well as the duration of UV exposure is described. Since the cross-linking is based on calcium concentration, the cross-linked alginate can easily be dissolved by EDTA. We also demonstrate application of this capability to patterned microscale 3D co-culture using endothelial cells and osteoblastic cells in a microchannel.

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“…In particular, when the hybrid films contained organic groups with curable units such as -C C-bonds, the thermal polymerization of -C C-bonds proceeded to enhance the cross-linking of the structure of hybrid materials and effectively terminated the migration pathways of the doped molecules. From the relationship between the curing of organic groups and the migration behavior assisted by the electric field in hybrid materials, the photocuring procedure (photolithography) [11][12][13] is expected to be compatible with the CED technique for developing a new process for the fabrication of 'fine doping structures'. In this study, we demonstrated 'molecular-doping lithography' by utilizing Solution TEVS MAPTMS TMOS TTIP IRGACURE184 a Sol-1 35 35 30 -Sol-2 -70 25 5 3 Sol-3 -70 20 10 -Sol-4 -70 20 10 3 a In mass%.…”

Section: Introductionmentioning

confidence: 99%

Formation of molecular doping patterns in organic–inorganic hybrid films by a capillary electrophoresis doping technique

Taguchi

Yano

Segawa

et al. 2009

Science and Technology of Advanced Materials

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A new technique is proposed for the fabrication of fine patterns of molecular doping in organic-inorganic hybrid materials by the combination of capillary electrophoresis doping (CED) and photolithography. The UV-induced polymerization of -C C-bonds in organic groups yields a fine contrast of structures with the desired pattern in organic-inorganic hybrid films, and CED treatment introduces functional molecules only into unirradiated regions to form the doping patterns of molecules inside the films. The fine patterning of rhodamine-6G doping with from 2 to 4 µm resolution is demonstrated in hybrid films of 10 µm thickness.

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Micropatterning of inorganic precipitations in hydrogels with soft lithography

Cited by 12 publications

References 29 publications

On‐Chip Screening of Experimental Conditions for the Synthesis of Noble‐Metal Nanostructures with Different Morphologies

On‐Chip Screening of Experimental Conditions for the Synthesis of Noble‐Metal Nanostructures with Different Morphologies

Patterning alginate hydrogels using light-directed release of caged calcium in a microfluidic device

Formation of molecular doping patterns in organic–inorganic hybrid films by a capillary electrophoresis doping technique

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