Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy

Orduna‐Hospital, Elvira; Otero-Rodríguez, Judit; Perdices, Lorena; Sánchez‐Cano, Ana; Boned‐Murillo, Ana; Acha, Joana; Pinilla, Isabel

doi:10.3390/diagnostics11010136

Cited by 13 publications

(11 citation statements)

References 27 publications

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“…The central inner ring of the MAIA perimetry correlated with the central macular thickness (r = − 0.347; p = 0.005). The results are similar to other studies, like Verma et al, [ 7 ] Senthil et al [ 37 ], and Orduna-Hospital et al [ 38 ], which also found a correlation between the foveal thickness and retinal sensitivity, while other authors also evaluated the relationship between retinal sensitivity and the thickness of the retinal inner layers (GCL and IPL) between healthy and patients with DM2 without DR, and did not find such a correlation [ 4 , 39 ].…”

Section: Discussionsupporting

confidence: 92%

Structural and functional findings in patients with moderate diabetic retinopathy

Boned‐Murillo

Barreda

Ferreras

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose To evaluate structural and functional ocular changes in patients with type 2 diabetes mellitus (DM2) and moderate diabetic retinopathy (DR) without apparent diabetic macular edema (DME) assessed by optical coherence tomography (OCT) and microperimetry. Methods This was a single-center cross-sectional descriptive study for which 75 healthy controls and 48 DM2 patients with moderate DR were included after applying exclusion criteria (one eye per patient was included). All eyes underwent a complete ophthalmic examination (axial length, macular imaging with swept-source OCT, and MAIA microperimetry). Macular thicknesses, ganglion cell complex (GCC) thicknesses, and central retinal sensitivity were compared between groups, and the relationships between the OCT and microperimetry parameters were evaluated. Results Macular thickness was similar in both groups (242.17 ± 35.0 in the DM2 group vs 260.64 ± 73.9 in the control group). There was a diminution in the parafoveal area thickness in the DM2 group in the GCC complex. Retinal sensitivity was reduced in all sectors in the DM2 group. The central global value was 24.01 ± 5.7 in the DM2 group and 27.31 ± 2.7 in the control group (p < 0.001). Macular integrity was 80.89 ± 26.4 vs 64.70 ± 28.3 (p < 0.001) and total mean threshold was 23.90 ± 4.9 vs 26.48 ± 2.6 (p < 0.001) in the DM2 and control group, respectively. Moderate correlations were detected between the central sector of MAIA microperimetry and retina total central thickness (− 0.347; p = 0.0035). Age, visual acuity, and hemoglobin A1c levels also correlated with retinal sensitivity. Conclusion Macular GCC thickness and central retinal sensitivity were reduced in patients with moderate DR without DME, suggesting the presence of macular neurodegeneration.

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Section: Discussionsupporting

confidence: 92%

Structural and functional findings in patients with moderate diabetic retinopathy

Boned‐Murillo

Barreda

Ferreras

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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“…Studies have also shown that mean retinal sensitivity declines with age in healthy eyes (Molina‐Martín et al, 2017; Sabates et al, 2011). While microperimetry and SD–OCT combined has been used to investigate macular structure–function relationships in AMD (Pilotto et al, 2016; Roh et al, 2019; Saßmannshausen et al, 2018; Sayegh et al, 2014; Steinberg et al, 2016; Tepelus et al, 2017; Wu et al, 2014), glaucoma (Garcia‐Medina et al, 2021) and diabetes without retinopathy (Montesano et al, 2021; Orduna‐Hospital et al, 2021), to the best of our knowledge, no prior work has tried to relate macular retinal layer thickness to mesopic visual sensitivity in younger, middle‐aged and older healthy adults.…”

Section: Introductionmentioning

confidence: 99%

Relationships between mesopic visual sensitivity and macular inner and outer retinal layer thickness in healthy younger, middle‐aged and older adults

Cedrún‐Sánchez,

Moreira‐Estebaranz,

Remis‐Gonzalez

et al. 2023

Acta Ophthalmologica

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PurposeTo examine relationships between mesopic visual sensitivity measurements on microperimetry and macular inner and outer retinal layer (IRL and ORL) thicknesses in healthy younger, middle‐aged and older subjects.MethodsIn total, 154 healthy adults were divided into three age groups each with similar mean sensitivity. Regional retinal sensitivity (determined by mesopic fundus‐controlled microperimetry) and IRL (ganglion cell‐related layer) and ORL thicknesses were measured in the five subfields: central fovea (1 mm diameter) and the quadrants temporal, nasal, superior and inferior of a parafoveal ring of outer diameter 3 mm and inner diameter 1 mm. Relationships between regional sensitivity and corresponding IRL and ORL thicknesses were assessed through a univariate and multivariate linear regression model.ResultsVisual sensitivity means for each subfield differed across age groups (all p < 0.001). In each parafoveal ring quadrant, mean IRL thickness was reduced in the older eyes compared to the other groups (all p < 0.0001). In the inferior region, worse sensitivity was correlated with greater IRL thickness (p = 0.0207) in the middle‐aged group and with a thicker ORL (p < 0.0001) and thinner IRL (p = 0.0003) in the older eyes (R2 = 0.51). The slopes of regression lines relating sensitivity to IRL thickness and age group (p = 0.0027) or to ORL thickness and age group (p = 0.0020) differed significantly.ConclusionsThe relationship observed between mesopic visual sensitivity and retinal layer thickness varied with age. A worse sensitivity was related to a thicker macular IRL layer in middle‐aged eyes and to a thicker ORL and thinner IRL in older eyes.

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“…25 Using microperimetry and OCT and/or FA, the reduction of retinal sensitivity with increasing DR severity has been well documented in conjunction with various morphologic features of DR including diabetic macular edema, reduced ganglion cell complex thickness, hard exudates, and capillary nonperfusion. [26][27][28][29][30][31][32][33][34][35][36][37] There are several recent studies comparing OCTA metrics with retinal sensitivity measured by microperimetry in diabetic retinopathy. [38][39][40][41] Although these studies report a positive association between OCTA parameters related to retinal ischemia (such as reduced vessel density and increased areas of capillary nonperfusion) and reduced MP sensitivity in DR, these comparisons have been predominantly qualitative.…”

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confidence: 99%

mentioning

confidence: 99%

Multiscale Correlation of Microvascular Changes on Optical Coherence Tomography Angiography With Retinal Sensitivity in Diabetic Retinopathy

Levine

Moult

Greig

et al. 2022

Retina

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Purpose: To assess global, zonal, and local correlations between vessel density changes measured by optical coherence tomography angiography and retinal sensitivity measured by microperimetry across diabetic retinopathy severity. Methods: Diabetic patients and nondiabetic controls underwent optical coherence tomography angiography imaging and microperimetry testing. Pearson's correlation was used to assess associations between average sensitivity and skeletonized vessel density (SVD) or foveal avascular zone area centrally. Linear mixed effects modeling was used to assess relationships between local SVD measurements and their spatially corresponding retinal sensitivity measurements. Results: Thirty-nine eyes from 39 participants were imaged. In all slabs, there was a statistically significant positive correlation between retinal sensitivities and SVDs on both global and zonal scales. No statistically significant correlation was found between central retinal sensitivities and the foveal avascular zone areas. Assessment of 1,136 spatially paired retinal sensitivity and SVD measurements revealed a statistically significant local relationship; this seemed to be driven by eyes with proliferative diabetic retinopathy that had reduced retinal sensitivities. Conclusion: This study supports positive correlations between SVD and retinal sensitivity at global and zonal spatial scales in diabetic eyes. However, our analysis did not find evidence of statistically significant correlations between retinal sensitivity and SVD on a local scale until advanced diabetic retinopathy.

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Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy

Cited by 13 publications

References 27 publications

Structural and functional findings in patients with moderate diabetic retinopathy

Structural and functional findings in patients with moderate diabetic retinopathy

Relationships between mesopic visual sensitivity and macular inner and outer retinal layer thickness in healthy younger, middle‐aged and older adults

Multiscale Correlation of Microvascular Changes on Optical Coherence Tomography Angiography With Retinal Sensitivity in Diabetic Retinopathy

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