In this paper atmospheric-pressure rf He+O2 cold plasmas are studied by means of a 1-D fluid model. 17 species and 60 key reactions selected from a study of 250+ reactions are incorporated in the model. O2+, O3-, and O are the dominant positive ion, negative ion, and reactive oxygen species, respectively. Ground state O is mainly generated by electron induced reactions and quenching of atomic and molecular oxygen metastables, while three-body reactions leading to the formation of O2 and O3 are the main mechanisms responsible for O destruction. The fraction of input power dissipated by ions is ∼20%. For the conditions considered in the study ∼6% of the input power is coupled to ions in the bulk and this amount will increase with increasing electronegativity. Radial and electrode losses of neutral species are in most cases negligible when compared to gas phase processes as these losses are diffusion limited due to the large collisionality of the plasma. The electrode loss rate of neutral species is found to be nearly independent of the surface adsorption probability p for p > 0.001 and therefore plasma dosage can be quantified even if p is not known precisely.