Aerosol and aerosol-cloud radiation interactions significantly influence Earth’s radiative balance, hydrological cycle, global monsoons, atmospheric circulation, and climate, attracting substantial scientific attention. This study employs bibliometric and quantitative trend analyses to evaluate the development, knowledge structure, and research trends in aerosol and aerosol-cloud radiation interactions from 1999 to 2023 using Web of Science Core Collection data. Results reveal a consistent increase in publications and citations, indicating sustained attention in this field. The USA and China are identified as the most prolific countries, with significant contributions from institutions like the National Aeronautics and Space Administration and the Chinese Academy of Sciences. However, while the USA shows a recent decline in growth, China has demonstrated a significant upward trend in research contributions. Productive journals include Atmospheric Chemistry and Physics and the Journal of Geophysical Research-Atmospheres, with prolific authors such as Babu S. Suresh and Li Zhanqing. A co-occurrence analysis of keywords identifies research topics focused on aerosol optical properties, aerosol types, aerosol radiation interactions, and aerosol-cloud interactions. Emerging trends emphasize advanced methodologies such as remote sensing, model simulation, and artificial intelligence, with growing attention to regions like the Southern Ocean and the Arctic. This comprehensive analysis provides valuable insights for researchers, identifying knowledge gaps and guiding future research directions in aerosol and aerosol-cloud radiation interactions, which are crucial for understanding their climatic and atmospheric impacts.