Microplastics alter development, behavior, and innate immunity responses following bacterial infection during zebrafish embryo-larval development

RABEZANAHARY, Andry Ny Aina; Piette, Mathilde; Missawi, Omayma; Garigliany, Mutien; Kestemont, Patrick; Cornet, Valérie

doi:10.1016/j.chemosphere.2022.136969

Cited by 14 publications

(3 citation statements)

References 77 publications

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“…MNPs are capable of crossing biological barriers and entering the circulatory system, where they reduce energy reserves through mechanical destruction, ultimately affecting the immune system [61]. (I) It was found that zebrafish exposed to MNPs had significant increases in mRNA and protein levels of genes associated with the innate immune system (interleukin-1α (IL-1α), IL-1β, nuclear factor-κb (NF-κb), and interferon) and apoptosis (casp3A and BCL2) [62].…”

Section: Metabolism and Immune System Of Zebrafishmentioning

confidence: 99%

Advances in the Utilization of Zebrafish for Assessing and Understanding the Mechanisms of Nano-/Microparticles Toxicity in Water

Lei

Zhang

et al. 2023

Toxics

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A large amount of nano-/microparticles (MNPs) are released into water, not only causing severe water pollution, but also negatively affecting organisms. Therefore, it is crucial to evaluate MNP toxicity and mechanisms in water. There is a significant degree of similarity between the genes, the central nervous system, the liver, the kidney, and the intestines of zebrafish and the human body. It has been shown that zebrafish are exceptionally suitable for evaluating the toxicity and action mechanisms of MNPs in water on reproduction, the central nervous system, and metabolism. Providing ideas and methods for studying MNP toxicity, this article discusses the toxicity and mechanisms of MNPs from zebrafish.

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Section: Metabolism and Immune System Of Zebrafishmentioning

confidence: 99%

Advances in the Utilization of Zebrafish for Assessing and Understanding the Mechanisms of Nano-/Microparticles Toxicity in Water

Lei

Zhang

et al. 2023

Toxics

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“…Among the known pathogens, Aeromonas salmonicida achromogenes is responsible for furunculosis, which is characterized by boils and systemic hemorrhaging, resulting in significant mortality in aquaculture systems [ 19 , 20 ] and consequent financial losses. Moreover, several studies have demonstrated the ability of A. salmonicida achromogenes to trigger inflammation and immune processes in rainbow trout and zebrafish [ 21 , 22 , 23 ]. Nevertheless, very little is known about the effects of this infection on the rainbow trout microbiota and immune status modifications associated.…”

Section: Introductionmentioning

confidence: 99%

The Pathogen Aeromonas salmonicida achromogenes Induces Fast Immune and Microbiota Modifications in Rainbow Trout

et al. 2023

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Environmental stressors can disrupt the relationship between the microbiota and the host and lead to the loss of its functions. Among them, bacterial infection caused by Aeromonas salmonicida, the causative agent of furunculosis, results in high mortality in salmonid aquaculture. Here, rainbow trout were exposed to A. salmonicida achromogenes and its effects on the taxonomic composition and structure of the microbiota was assessed on different epithelia (gills, skin, and caudal fin) at 6 and 72 h post-infection (hpi) using the V1–V3 region of the 16S rRNA sequencing. Moreover, the infection by the pathogen and immune gene responses were evaluated in the head kidney by qPCR. Our results suggested that α-diversity was highly diverse but predominated by a few taxa while β-diversity was affected very early by infection in the gills after 6 h, subsequently affecting the microbiota of the skin and caudal fin. A dysbiosis of the microbiota and an increase in genera known to be opportunistic pathogens (Aeromonas, Pseudomonas) were also identified. Furthermore, an increase in pro-inflammatory cytokines and virulence protein array (vapa) was observed in trout head kidney as soon as 6 hpi and remained elevated until 72 hpi, while the anti-inflammatory genes seemed repressed. This study suggests that the infection by A. salmonicida achromogenes can alter fish microbiota of gills in the few hours post-infection. This result can be useful to develop a non-invasive technique to prevent disease outbreak in aquaculture.

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“…Moreover, it has been shown that MPs alone can induce toxic effects on aquatic invertebrate species including cnidarians (Beraud et al, 2022;Chen et al, 2022b;Lim et al, 2022;Marangoni et al, 2022), mollusks (Detree and Gallardo-Escarate, 2018;Green et al, 2019;Magni et al, 2019;Pedersen et al, 2020;Uguen et al, 2022;Weber et al, 2021;Zheng et al, 2022), cladocerans (Chenxi et al, 2022;Eltemsah and Bohn, 2019;Kokalj et al, 2018;Mondellini et al, 2022;Wang et al, 2022b;Wang et al, 2022c;Zebrowski et al, 2022), and echinoderms (Martinez-Gomez et al, 2017;Murano et al, 2020;Ng et al, 2022;Nobre et al, 2015;Rendell-Bhatti et al, 2021;Richardson et al, 2021;Trifuoggi et al, 2019). Also, fish species have been shown to be sensitive to the single effects of MPs (Banaei et al, 2022;Chen et al, 2017;Chen et al, 2020;Cormier et al, 2022;Felix et al, 2023;Jabeen et al, 2018;Kim et al, 2022;LeMoine et al, 2018;Rabezanahary et al, 2023;Yu et al, 2022a;Zhang et al, 2022). Besides, given their high surface hydrophobicity, MPs have a very high sorption capacity for hydrophobic pollutants (e.g., different pharmacologically active compounds [PhACs] or polycyclic aromatic hydrocarbons); hence they ca...…”

Section: Introductionmentioning

confidence: 99%

Presence, Variation, and Potential Ecological Impact of Microplastics in the Largest Shallow Lake of Central Europe

Svigruha¹,

Prikler

Farkas³

et al. 2022

SSRN Journal

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Microplastics alter development, behavior, and innate immunity responses following bacterial infection during zebrafish embryo-larval development

Cited by 14 publications

References 77 publications

Advances in the Utilization of Zebrafish for Assessing and Understanding the Mechanisms of Nano-/Microparticles Toxicity in Water

Advances in the Utilization of Zebrafish for Assessing and Understanding the Mechanisms of Nano-/Microparticles Toxicity in Water

The Pathogen Aeromonas salmonicida achromogenes Induces Fast Immune and Microbiota Modifications in Rainbow Trout

Presence, Variation, and Potential Ecological Impact of Microplastics in the Largest Shallow Lake of Central Europe

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