Microplastics exposure induced and exacerbated the development of systemic lupus erythematosus in mice

Chen, Huinan; Wan, Li; Qiu, Yiwu; Qiu, Fuhai; Wen, Chengping; Mao, Yingying; He, Zhixing

doi:10.1016/j.scitotenv.2023.168586

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Peripheral macrophages in the blood readily engulf microplastics whilst peripheral blood mononuclear cells (PBMC) release pro-inflammatory cytokines (e.g., IL-6 and TNF-α), especially in response to fragmented microplastics [56,63]. A study using both spontaneous lupus-prone (MRL/lpr) and healthy mice found that the inflammatory response to microplastic exposure was accompanied by elevated serum autoantibodies indicative of systemic lupus erythematosus in both groups [94]. Microplastics also impair the cardiovascular system, as faecal microplastic concentration was positively correlated with vascular calcification score (in 47 patients with and without vascular calcification), while in rats, microplastic exposure aggravated existing vascular calcification and induced new mild vascular calcification [45].…”

Section: Microplastics Induce Peripheral Diseasementioning

confidence: 99%

“…Additionally, mechanistic, in vitro studies observed inflammation, apoptosis, and cytotoxicity in liver and kidney cells after microplastic exposure [95,96]. In rodents, disease was associated with disruption of the gut-liver-axis and gut-kidney-axis via microplastic-induced intestinal dysbiosis, and consequent changes to key gut metabolites and pathways associated with gut-liver and gutkidney function [31][32][33]45,94,97]. Metabolic balance is critical to maintain healthy systems, therefore metabolic alterations are another mechanism by which microplastics exacerbate peripheral disease.…”

Section: Microplastics Induce Peripheral Diseasementioning

confidence: 99%

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Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences

Sofield,

Anderton,

Gorecki

2024

CIMB

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As environmental plastic waste degrades, it creates an abundance of diverse microplastic particles. Consequently, microplastics contaminate drinking water and many staple food products, meaning the oral ingestion of microplastics is an important exposure route for the human population. Microplastics have long been considered inert, however their ability to promote microbial dysbiosis as well as gut inflammation and dysfunction suggests they are more noxious than first thought. More alarmingly, there is evidence for microplastics permeating from the gut throughout the body, with adverse effects on the immune and nervous systems. Coupled with the now-accepted role of the gut-brain axis in neurodegeneration, these findings support the hypothesis that this ubiquitous environmental pollutant is contributing to the rising incidence of neurodegenerative diseases, like Alzheimer’s disease and Parkinson’s disease. This comprehensive narrative review explores the consequences of oral microplastic exposure on the gut-brain-axis by considering current evidence for gastrointestinal uptake and disruption, immune activation, translocation throughout the body, and neurological effects. As microplastics are now a permanent feature of the global environment, understanding their effects on the gut, brain, and whole body will facilitate critical further research and inform policy changes aimed at reducing any adverse consequences.

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