2005
DOI: 10.1007/s10856-005-6988-1
|View full text |Cite
|
Sign up to set email alerts
|

Microporosity enhances bioactivity of synthetic bone graft substitutes

Abstract: This paper describes an investigation into the influence of microporosity on early osseointegration and final bone volume within porous hydroxyapatite (HA) bone graft substitutes (BGS). Four paired grades of BGS were studied, two (HA70-1 and HA70-2) with a nominal total porosity of 70% and two (HA80-1 and HA80-2) with a total-porosity of 80%. Within each of the total-porosity paired grades the nominal volume fraction of microporosity within the HA struts was varied such that the strut porosity of HA70-1 and HA… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

7
251
0

Year Published

2009
2009
2016
2016

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 289 publications
(258 citation statements)
references
References 20 publications
7
251
0
Order By: Relevance
“…A literature review indicates that a pore size in the range of 10-400 lm may provide enough nutrient and osteoblast cellular infusion, while maintaining structural integrity. [185][186][187][188][189][190] A wide variety of fabrication techniques have been investigated to recreate the microscale porosity and special organization of native bone. Some examples of well developed techniques include: micromachining, photolithography, calcium-phosphate sintering, rapid prototyping, melt extrusion, salt leaching, emulsion templating, phase separation, fiber bonding, membrane lamination, and polymer demixing.…”
Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning
confidence: 99%
“…A literature review indicates that a pore size in the range of 10-400 lm may provide enough nutrient and osteoblast cellular infusion, while maintaining structural integrity. [185][186][187][188][189][190] A wide variety of fabrication techniques have been investigated to recreate the microscale porosity and special organization of native bone. Some examples of well developed techniques include: micromachining, photolithography, calcium-phosphate sintering, rapid prototyping, melt extrusion, salt leaching, emulsion templating, phase separation, fiber bonding, membrane lamination, and polymer demixing.…”
Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning
confidence: 99%
“…Thus, there is no need to create calcium orthophosphate bioceramics with very big pores; however, the pores must be interconnected [95,384,397,398]. Interconnectivity governs a depth of cells or tissue penetration into the porous bioceramics, as well as it allows development of blood vessels required for new bone nourishing and wastes removal [455,456].…”
Section: Porositymentioning
confidence: 99%
“…Bioceramic microporosity (pore size < 10 μm), which is defined by its capacity to be impregnated by biological fluids [455], results from the sintering process, while the pore dimensions mainly depend on the material composition, thermal cycle and sintering time. The microporosity provides both a greater surface area for protein adsorption and increased ionic solubility.…”
Section: Porositymentioning
confidence: 99%
See 1 more Smart Citation
“…Bone formation begins with the formation of an apatite layer which enhances protein adsorption resulting in the differentiation of osteoprogenitor cells into osteoblasts leading to the deposition of bone (25). In order for the apatite layer to form, the bone graft material must first come into contact with blood, which facilitates the dissolution of the graft and its re-precipitation onto the surface (14,24,25). In addition, blood is an abundant source of proteins, which would further enhance this process.…”
Section: Discussionmentioning
confidence: 99%