Microporous polysaccharide hemospheres for management of laparoscopic trocar injury to the spleen

Humphreys, Mitchell R.; Castle, Erik P.; Andrews, Paul; Gettman, Matthew T.; Ereth, Mark H.

doi:10.1016/j.amjsurg.2007.03.006

Cited by 48 publications

(40 citation statements)

References 19 publications

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“…In a follow-up study by Murat et al [4], a similar model was performed laparoscopically, in which 33.3% of applications required an additional 1 g application more than once. Humphreys et al [6] investigated the efficacy of MPH in a 5-and 12-mm trocar lesion of the spleen in swine; no comparator was used. In 42.8% of the 12-mm lesions and 33.3% of the 5-mm lesions, 0.5 g of MPH had to be applied more than once.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of hemostatic matrix and microporous polysaccharide hemospheres

Lewis

Atlee

Mannone

et al. 2015

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Efficacy of hemostatic matrix and microporous polysaccharide hemospheres

Lewis

Atlee

Mannone

et al. 2015

Journal of Surgical Research

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“…Humphreys et al (7,8) have found MPH to be an effective hemostatic agent in studies performed with laparoscopic trocar injuries to the kidney and spleen in pigs. Ersoy et al have reported that MPH is effective in the hemostasis of severe femoral arterial bleeding in rats (5).…”

Section: Mph (Microporous Polysaccharide Hemospheres)mentioning

confidence: 99%

Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety

Emmez

Tönge²,

Tokgöz³

et al. 2010

Turkish Neurosurgery

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AIM: Topical hemostatic agents are widely used in brain surgery but they have some disadvantages such as foreign body reaction, being a focus for infection and causing artifacts in radiological examinations. The purpose of this study is to compare the effectiveness and safety of microporous polysaccharide hemospheres (MPH) with a well known agent, oxidized regenerated cellulose (ORC), histopathologically and radiologically. MATeRIAL and MeTHodS: Standard brain lesions (4x1mm) were created in 24 hemispheres in 12 New-Zealand rabbits. Animals were divided into three groups; control, ORC and MPH. Twenty-four hours later, all rabbits magnetic resonance brain imaging. After imaging, the animals were sacrificed and the brains were removed for histopathological analysis. ReSULTS: Histopathological analysis showed no significant difference between the groups. Radiological examination showed no significant difference between the MPH and ORC groups in terms of edema but the edema in control group was significantly prominent than MPH and ORC groups (p<0.001). CoNCLUSIoN: A new agent (MPH) provides safe and effective hemostasis in the brain in this study. The most important advantage of microporous polysaccharide hemospheres is their rapid clearance from the surgical field and therefore having the potential of causing less imaging artifacts.

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“…This was in line with our previous study, in which MPH presented a very weak, if any, hemostatic effect. There are studies 13,20 where MPH seems effective in providing hemostasis. These experimental studies are, however, performed in non-anticoagulated animals.…”

Section: Topical Haemostatics In Renal Traumamentioning

confidence: 97%