Microradiographic and Microscopic Studies on in situ Induced Initial Caries in Irradiated and Nonirradiated Dental Enamel

Kielbassa, Andrej M.; Schendera, Anke; Schulte‐Mönting, Jürgen

doi:10.1159/000016568

Cited by 44 publications

(52 citation statements)

References 30 publications

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“…On the other hand, in studies using powdered enamel or apatite an increased solubility of irradiated, human enamel has also been reported [Pioch et al, 1991;Tepel et al, 1992]. Nevertheless, in situ investigations using TMR [Kielbassa et al, 1997b[Kielbassa et al, , 2000 seem to be more reliable to measure the outcome of irradiation. Thus, in light of the present data it seems very likely that irradiation does not infl uence demineralization of human enamel.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Irradiation on in situ Remineralization of Human and Bovine Enamel Demineralized in vitro

2006

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The objective of this study was to evaluate the effects of irradiation and surface condition on in situ remineralization of demineralized human and bovine enamel. Specimens (n = 96) obtained from 24 human molars and 24 bovine incisors were prepared. The surfaces of half of the specimens were abraded while the others remained natural. Each of the 12 human and bovine abraded and sound specimens was irradiated fractionally up to 46.5 Gy (3.1 Gy/day, 5 days/week), while the remaining samples were not irradiated. Prior to and following the demineralization (pH 5.0; 14 days) all specimens were partly covered with nail varnish (control). After in vitro demineralization 2 irradiated and 2 nonirradiated specimens were inserted into both buccal aspects of 12 intraoral appliances, which were worn by 12 persons for a period of 6 weeks. All samples were brushed twice a day with a fluoride-containing toothpaste. Mineral analyses revealed a significant influence on mineral loss (ΔZ_demin), mineral gain (ΔΔZ), lesion depth (LD_demin), and lesion depth reduction (ΔLD) of the variables ‘material’ and ‘irradiation’ (p < 0.05; ANOVA). Reciprocal interactions could be observed between these two variables for ΔZ_demin, ΔΔZ, and LD_demin, due to significantly reduced values found for the irradiated, abraded bovine specimens compared to the nonirradiated ones (p < 0.05; Bonferroni post hoc test). It can be concluded that neither irradiation nor abrasion influenced in vitro demineralization or in situ remineralization of the human specimens, whereas abrasion hampered demineralization in irradiated, bovine specimens.

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Section: Discussionmentioning

confidence: 99%

“…On the other hand, it was observed in an in situ demineralization model that irradiated human enamel is as caries susceptible as nonirradiated. It was concluded that possible irradiation effects are not likely to be responsible for initial demineralization under clinical conditions [Kielbassa et al, 2000]. …”

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Effects of Irradiation on in situ Remineralization of Human and Bovine Enamel Demineralized in vitro

2006

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“…Studies on the mechanical properties of irradiated teeth are often hampered by "nonphysiological" conditions, such as the application of mechanical forces that exceeded the elastic limit of the samples 2,3) . Nonetheless, radiation caries seems to originate from radiation-induced defects in the amelodentinal junction and changes in the oral flora [4][5][6] due to reduced salivary flow rate and poor oral hygiene 7) . Besides irradiation-induced xerostomia, the effect of irradiation on dental hard tissues may be an important factor in radiation caries.…”

Section: Introductionmentioning

confidence: 99%

Bond strengths of two conventional glass-ionomer cements to irradiated and non-irradiated dentin

et al. 2008

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This study evaluated the influence of irradiation on the dentin shear bond strength of two conventional glass ionomer cements (GICs). Thirty extracted molars were bisected in the mesio-distal direction. One-half of 20 teeth were irradiated with 60 Gy (5 days/week) for 6 weeks, and then GIC was placed on the irradiated dentin surface (Groups A1, B1). For the other halves of these tooth specimens, the GICs were first placed on their dentin surfaces and then the specimens irradiated (Groups A2, B2). The remaining 10 teeth were bisected and used as non-irradiated controls (Groups C1, C2). The GICdentin shear bond strengths were examined. Groups A2 and B2 had significantly lower bond strengths than groups A1, B1, C1, and C2 (p<0.05). No significant differences were found among groups A1, B1, C1, and C2 (p>0.05). In conclusion, irradiation may have an adverse effect on the bond strength of GICs depending on the application sequence.

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“…16,17,24,25,26,27 However, only limited information is available concerning these effects on both enamel and dentine. Moreover, most of the previous investigations had limitations with regard to the instruments used, and there has been little study concerning the relationship between radiation dose and mechanical properties.…”

Section: Discussionmentioning

confidence: 99%

Effect of high energy X-ray irradiation on the nano-mechanical properties of human enamel and dentine

Zhang

Cheng

et al. 2016

Braz. oral res.

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Radiotherapy for malignancies in the head and neck can cause common complications that can result in tooth damage that are also known as radiation caries. The aim of this study was to examine damage to the surface topography and calculate changes in friction behavior and the nano-mechanical properties (elastic modulus, nanohardness and friction coefficient) of enamel and dentine from extracted human third molars caused by exposure to radiation. Enamel and dentine samples from 50 human third molars were randomly assigned to four test groups or a control group. The test groups were exposed to high energy X-rays at 2 Gy/day, 5 days/week for 5 days (10 Gy group), 15 days (30 Gy group), 25 days (50 Gy group), 35 days (70 Gy group); the control group was not exposed. The nanohardness, elastic modulus, and friction coefficient were analyzed using a Hysitron Triboindenter. The nano-mechanical properties of both enamel and dentine showed significant dose-response relationships. The nanohardness and elastic modulus were most variable between 30-50 Gy, while the friction coefficient was most variable between 0-10 Gy for dentine and 30-50 Gy for enamel. After exposure to X-rays, the fracture resistance of the teeth clearly decreased (rapidly increasing friction coefficient with increasing doses under the same load), and they were more fragile. These nano-mechanical changes in dental hard tissue may increase the susceptibility to caries. Radiotherapy caused nano-mechanical changes in dentine and enamel that were dose related. The key doses were 30-50 Gy and the key time points occurred during the 15 th -25 th days of treatment, which is when application of measures to prevent radiation caries should be considered.

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Microradiographic and Microscopic Studies on in situ Induced Initial Caries in Irradiated and Nonirradiated Dental Enamel

Cited by 44 publications

References 30 publications

Effects of Irradiation on in situ Remineralization of Human and Bovine Enamel Demineralized in vitro

Effects of Irradiation on in situ Remineralization of Human and Bovine Enamel Demineralized in vitro

Bond strengths of two conventional glass-ionomer cements to irradiated and non-irradiated dentin

Effect of high energy X-ray irradiation on the nano-mechanical properties of human enamel and dentine

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