Microreactor numbering-up in multi-scale networks for industrial-scale applications: Impact of flow maldistribution on the reactor performances

Saber, Meryem; Commenge, Jean‐Marc; Laurent, Fabrice

doi:10.1016/j.ces.2009.06.010

Cited by 123 publications

(82 citation statements)

References 24 publications

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“…The design of the bioreactors, modelling and prediction of operational conditions is thus of vital importance. The recent trend is to further miniaturize milliliter-scale reactors to the microliter scale, with the introduction of microstructured reactors [10]. Although all these platforms are clearly fit for high-throughput applications, limitations can be pointed out within them, such as: (i) limited culture volumes, (ii) medium evaporation and (iii) difficult process control.…”

Section: Introductionmentioning

confidence: 99%

“…constant oxygen transfer rate (k L a), maintenance of geometric parameters and constant volumetric power consumption (P/V) [12]. The former method enables high production volumes at relatively low cost as it is based on economyof-mass manufacturing while the latter is economy-of-scale based [10]. The study of the limiting steps will allow the full understanding of the economic viability of the process [8].…”

Section: Introductionmentioning

confidence: 99%

“…This can be accomplished by two ways: (i) extrapolation by combination, e.g. assembling a large number of micro-reactors [10] or (ii) the process can be volumetrically scaledup using suitable criteria, e.g. constant oxygen transfer rate (k L a), maintenance of geometric parameters and constant volumetric power consumption (P/V) [12].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anchoring high-throughput screening methods to scale-up bioproduction of siderophores

Marques

Walshe

Doyle

et al. 2012

Process Biochemistry

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a b s t r a c tThe use of high throughput strategies is of acknowledged relevance since the rational use of small-scale reactors, coupled with suitable analytic tools, is contributing to the acceleration of process development in several areas of biotechnology. These small-scale reactors are available in different working volumes and configurations, being useful in a wide array of applications, from cell screening to process optimization.The present work was focused on the development of a high-throughput strategy, combining microtiter plates and analytic methodologies, to screen an in-house library of environmental bacteria in order to identify good siderophore producers. From a library of roughly 500 marine microorganisms, it was possible to ultimately obtain 11 bacterial strains with high production capabilities. Two of them had not been previously identified as siderophore producers. The bioprocess was scaled-up from microtiter plates to a 5 L stirred tank reactor, while maintaining the overall volumetric productivity, using the k L a similarity as scale-up criterion.This novel approach is a suitable alternative to traditional screening tools.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anchoring high-throughput screening methods to scale-up bioproduction of siderophores

Marques

Walshe

Doyle

et al. 2012

Process Biochemistry

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“…Therefore, the fluid distribution uniformity among the parallel channels may play an important role on the global performance of multi-channel equipments. This is particularly true when multi-scale ladder-type fluid networks ( Figure 1a) are involved (Saber et al 2010;Commenge et al 2011). In order to achieve uniform flow distribution among all parallel channels in the network, the first and essential step is the design of an optimized two-scale elementary Z-type ladder circuit, as shown in Figure 1b.…”

Section: Introductionmentioning

confidence: 99%

Numerical study on the improvement of flow distribution uniformity among parallel mini-channels

Pistoresi

Fan

Luo

2015

Chemical Engineering and Processing: Process Intensification

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Parallel micro or mini-channels are widely used in various devices of process and energy engineering including microreactors, compact heat exchangers and fuel cells. Nevertheless, the flow maldistribution due to the improper design of distributor/collector is usually observed, leading to globally poor performances of these devices. The objective of this study is to optimize the shape of the distributor/collector pipes so as to achieve a uniform flow distribution among an array of parallel minichannels. A Z-type ladder fluid network with 10 mini-channels in parallel having square section is introduced and investigated. Two methods are used to optimize the shape of distributor/collector pipes: a discrete stairway shape optimized according to the scaling relations proposed by Tondeur et al. (2011) and a continuous tapered shape with the inclined angle varying from 0° to 30°. 3D-CFD simulations are carried out using the ANSYS FLUENT code. Numerical results obtained show that a relatively uniform flow distribution may be reached by the discrete stairway shape or by the linear tapered shape under very low flow-rate conditions. Larger inclined angle or fewer channels in parallel are favorable for more uniform flow distribution under higher flow-rate conditions. Nevertheless this implies that the distributor and the collector pipes occupy a large volume so that the entire device is less compact.

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“…The flow regimes inside these microdevices tend to be of the transitional or turbulent type, and it is now critical to determine the optimal size of manifold microchannels in order to both reduce the pressure drop and control microflow dynamics within these milli-or microexchangers (Saber et al 2009(Saber et al , 2010). Yet in this pursuit, researchers generally end up confronting a number of interdependent problems.…”

Section: Introductionmentioning

confidence: 99%

Unsteady flows in milli- and microsystems: analysis of wall shear rate fluctuations

Huchet¹,

Legentilhomme

Legrand

et al. 2011

Exp Fluids

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To cite this version:Abstract The particular benefits of microfluidic systems, in terms of heat and mass transfer enhancement, require conducting local flow diagnostics, especially when unsteady properties of the microflow can play a critical role at the reaction interface, as currently observed in the fields of bioengineering and chemical engineering. The present paper focuses on unsteady confined flows within microsystems characterized by various geometries of crossing channels and exhibiting high surface-to-volume ratios. An experimental analysis of the signal measured at microsensors embedded to the wall of microsystems is discussed. In the objective of performing flow diagnostics, including regime identification and wall flow structure recognition, two methods for electrochemical signal processing are investigated and compared within an experimental network of crossing minichannels. One method is based on the use of a transfer function, while the other, the so-called Sobolik solution (Sobolik et al. in Coll Czech Chem Commun 52:913-928, 1987), consists of finding a direct solution to the mass balance equation. Sobolik's method has been selected given its ability to provide a description, over a wide range of Reynolds numbers (317 \ Re \ 3,535), for all wall shear rate fluctuations, as well as for the associated mixing scales in the power spectra density (PSD). This technique is then applied to flow within micromixers composed of two crossing microchannels in order to study highly unsteady and inhomogeneous microflows. The hydraulic diameters of the studied channels are 500 and 833 lm, respectively. Two flow patterns are investigated herein: the crossing-flow type and the impinging flow (or so called co-flow) for a Reynolds number range between 173 and 3,356. The PSD of wall shear rate fluctuations reveals various flow characteristics depending on the microchannel aspect ratio.

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Microreactor numbering-up in multi-scale networks for industrial-scale applications: Impact of flow maldistribution on the reactor performances

Cited by 123 publications

References 24 publications

Anchoring high-throughput screening methods to scale-up bioproduction of siderophores

Anchoring high-throughput screening methods to scale-up bioproduction of siderophores

Numerical study on the improvement of flow distribution uniformity among parallel mini-channels

Unsteady flows in milli- and microsystems: analysis of wall shear rate fluctuations

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