Microreactor studies for efficient organic oxidation processes

Taylor bubble formation and flowing in a straight millimetric channel with a cross-junction inlet geometry Part II: Gas-liquid mass transfer

“…Microstructured continuous-flow technology is now considered as one of the effective approaches for process intensification and gained many interests for a wide range of applications (Geng et al, 2020;Liu et al, 2020;Yan et al, 2021), especially for multiphase reactions (e.g., hydrogenation and (photo)oxidation). They could indeed offer several advantages compared to conventional batch processes, such as the enhanced heat and mass transfer rates, narrow residence time distribution, high exchange surface areas, and higher yields and selectivity (Willms et al, 2019;Mariotti et al, 2020;Xu et al, 2021;Yang et al, 2022).…”

Catalytic Oxidation of o-Chlorotoluene with Oxygen to o-Chlorobenzaldehyde in a Microchannel Reactor

“…In recent years, considerable achievements have been made in microchannel reactor technology in the chemical field because of the advancement of science and technology. − Compared with traditional batch reactors, continuous flow microchannel reactors show the inherent characteristics of a large specific surface area and high heat and mass transfer efficiencies, which allow fine control of the reaction conditions, good operability, high safety, less degradation and side products, and an easier path to scale-up. ,− To date, microchannel reactors have been successfully applied in various organic reactions, such as aldol condensation, , Michael addition, , nucleophilic addition with organometallic reagents, the Wittig reaction, Suzuki–Miyaura coupling, Diels–Alder addition, Wolff–Kishner reduction of carbonyls, and especially aerobic oxidation of various substrates. − For the applications of flow microchannel reactor technology to aerobic oxidations, Stahl, , Gavriilidis, and Vanoye conducted aerobic oxidation reactions on alcohols and aldehydes through microchannel reactor technology and achieved good results. In addition, Gemoets, Willms, and Kappe − also reported many successful results on the use of continuous flow microchannel reactor technology for aerobic oxidations.…”

“…31−41 For the applications of flow microchannel reactor technology to aerobic oxidations, Stahl, 31,32 Gavriilidis, 33 and Vanoye 34 conducted aerobic oxidation reactions on alcohols and aldehydes through microchannel reactor technology and achieved good results. In addition, Gemoets, 35 Willms, 36 and Kappe 37−41 also reported many successful results on the use of continuous flow microchannel reactor technology for aerobic oxidations.…”