Microreactors: New Opportunities in Chemical Synthesis

Abstract

Abstract:The implementation of chemical reactions in continuous mode under microfluidic conditions by the use of microreactors is a very attractive alternative to the traditional batch and semi-batch mode currently used for chemical synthesis. The fine control of the stoichiometry, kinetics and thermal exchange of the reaction, as well as the easy scale up, low physical space demand for installation/operation and the easy implementation of in-line analysis techniques for in process controls approach the laboratory development to a reproducible, robust, safe, cost-competitive and environmentally sustainable chemical process. ResumoA execução de reações químicas em modo contínuo de operação sob condições microfluídicas em micro reatores é uma alternativa muito atraente às condições em batelada e semi batelada tradicionalmente empregadas para a síntese química. O fino controle da estequiometria, cinética e troca térmica da reação em execução, bem como a facilidade na ampliação de escala de produção, baixa demanda por espaço físico para sua instalação/operação e viabilidade na implementação de técnicas de análise em linha para os controles em processo, aproximam o desenvolvimento laboratorial da implementação de um processo químico reprodutível, robusto, seguro, de custo competitivo e ambientalmente sustentável.Palavras-chave: Micro reatores; processos químicos; química em fluxo.

Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate

“…In MRT, the reactions occur under microfluidic conditions within microchannels , in devices with sizes normally on the order of 100 μm, the volumes of which cover the range from microliters to milliliters , , . Owing to the small size, the flow is mainly laminar, which promotes homogenization only by diffusion, making contact among molecules easier .…”

Plantas Que Agem No Sistema Nervoso Central: O Uso Dos Fitoterápicos Kava Kava, Passiflora E Valeriana No Tratamento De Transtorno De Ansiedade

“…Outra vantagem da TMR é a automatização do processo e a sua monitoração para poder obter produtos de maior qualidade (MACHADO et al, 2014). A TMR atualmente não é aplicada na indústria químico-farmacêutica nacional, porém são inegáveis as vantagens e benefícios que possui.…”

Flow Synthesis of 2‐[Methyl(pyridin‐2‐yl)amino]ethanol: An Experimental and Computational Study

“…The chemical-pharmaceutical industry produces a set of drugs of different therapeutic classes with different active ingredients and chemical compositions, which derive from new knowledge generated from research and development activities [1]. Drug synthesis is mainly carried out batchwise in multiphase reaction media, but when increasing the production scale, problems such as low mixing efficiency and temperature gradients often cause a low reaction selectivity in this type of process [2].…”

“…The use of microdevices such as chip-based microreactors has several advantages over the usual batch process, e.g., smaller amounts of reactants, less waste generation, lower risks of operator exposure to possible toxic chemicals [3], more efficient molecular diffusion, very high heat transfer rates due to the high surface-to-volume ratio, and higher reaction yield and selectivity [2]. In addition, it is possible to achieve the same production rate as a batch reactor by placing several microreactors in parallel (numbering-up) and ensure greater safety and better control of the reaction parameters, mainly under high temperature and pressure conditions [4].…”