Microrheological study of PVA/borax physical gels: Effect of chain length and elastic reinforcement by sodium hydroxide addition

Mahjoub, Hasna Faten; Zammali, Marouen; Abbes, Chayma; Othman, Tahar

doi:10.1016/j.molliq.2019.111272

Cited by 21 publications

(13 citation statements)

References 52 publications

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“…The emergent macroscopic property of dynamic covalent materials is determined by the specific physical interaction, and the concentration or dynamics of the gelling moiety can be tuned readily to greatly change the material properties. , The rate of boronate ester exchange was shown to affect the bulk material properties, where the diboronic ester with faster exchange rates showed higher malleability and higher rate of self-healing and could allow for more reprocessable networks . Injectable and self-healing hydrogels could be formed between diols and phenylboronic acids, with mechanical properties tunable by pH and release properties dependent on glucose levels. − Boronate-based systems could form into highly extensible hydrogels, with continuous bond formation and cleavage when stress was applied and could be chemically tuned and drawn into tough fibers by pultrusion. , When the ratio of PBA/diol was lowered, the cross-linked network showed more liquid behavior, except at the optimal binding conditions .…”

Section: Introductionmentioning

confidence: 99%

Versatile and Extendable Boronate-Based Tunable Hydrogel Networks for Patterning Applications

Tan

Cheng

Parikh

et al. 2022

ACS Appl. Polym. Mater.

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Hydrogel patterning is an emerging area of interest and a valuable tool for studying cellular interactions. However, patterning of hydrogels is normally performed with photo-cross-linkable moieties, severely limiting the choice of materials that can be used. Dynamic covalent cross-linked systems show highly desirable properties as they can show covalent and noncovalent characteristics in response to different environmental conditions, therefore allowing for a potential switch in hydrogel properties. To expand the repertoire of materials suitable for hydrogel patterning, we report versatile pregel polymer networks comprising poly(vinyl alcohol) cross-linked with PEG-diboronates cross-linkers at low ratios. These pregel networks are highly processable and extendable: they can be pulled up into thin strands and used for patterning of thin lines and exhibit both shear thinning and shear thickening properties. The pregels can be easily converted into a hydrogel state by pH adjustment and show clear antibacterial effects. Valuably, the pregels can be integrated into a 3D printing setup to print programmable lines and shapes and subsequently converted into patterned hydrogels. This study demonstrates that dynamic boronate networks can be tuned to exhibit different states and could offer alternate strategies and possibilities for hydrogel patterning applications.

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Section: Introductionmentioning

confidence: 99%

Versatile and Extendable Boronate-Based Tunable Hydrogel Networks for Patterning Applications

Tan

Cheng

Parikh

et al. 2022

ACS Appl. Polym. Mater.

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“…The specific mechanism of the complexity of PVA with borax is as follows: a borax mol is dissociated into 2 mol of borate ions and borate acid, as shown in Figure 1. The complexity mechanism of PVA-borate ions has two balances governed by interactions with hydrogen, monodiol, and didiol complexities [16]. The complex of PVA and borax in aqueous solutions has been thoroughly studied for several decades [17,18].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO3 and Demineralized Bone Matrix

Medrano-David

Lopera

Londoño

et al. 2021

JFB

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The occurrence of bone-related disorders and diseases has dramatically increased in recent years around the world. Demineralized bone matrix (DBM) has been widely used as a bone implant due to its osteoinduction and bioactivity. However, the use of DBM is limited because it is a particulate material, which makes it difficult to manipulate and implant with precision. In addition, these particles are susceptible to migration to other sites. To address this situation, DBM is commonly incorporated into a variety of carriers. An injectable scaffold has advantages over bone grafts or preformed scaffolds, such as the ability to flow and fill a bone defect. The aim of this research was to develop a DBM carrier with such viscoelastic properties in order to obtain an injectable bone substitute (IBS). The developed DBM carrier consisted of a PVA/glycerol network cross-linked with borax and reinforced with CaCO3 as a pH neutralizer, porosity generator, and source of Ca. The physicochemical properties were determined by an injectability test, FTIR, SEM, and TGA. Porosity, degradation, bioactivity, possible cytotoxic effect, and proliferation in osteoblasts were also determined. The results showed that the developed material has great potential to be used in bone tissue regeneration.

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“…The specific mechanism of the complexity of PVA with borax is as follows: a borax mol is dissociated into 2 mol of borate ions and borate acid as shown in Figure 1. The complexity mechanism of PVA-borate ions has two balances governed by interaction with hydrogen, monodiol, and didiol complexities [15]. The complex of PVA and Borax in aqueous solutions has been thoroughly studied for several decades [16] [17].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/borax /CaCO3 and Demineralized Bone Matrix

Medrano-David¹,

Lopera²,

Londoño³

et al. 2021

Preprint

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The occurrence of bone-related disorders and diseases has increased dramatically in recent years around the world. Demineralized bone matrix (DBM) has been widely used as a bone implant due to its osteoinduction and bioactivity. However, the use of DBM is limited because it is a particulate material, which makes it difficult to manipulate and implant with precision, in addition, these particles are susceptible to migrate to other sites. To address this situation, DBM is commonly incorporated into a variety of carriers. An injectable scaffold has advantages over bone grafts or preformed scaffolds, such as the ability to flow and fill the bone defect. The aim of this research is to develop a DBM carrier with such viscoelastic properties to obtain an injectable bone substitute (IBS). The DBM carrier developed consisted of a PVA/glycerol network cross-linked with borax and reinforced with CaCO3 as a pH neutralizer, porosity generator, and source of Ca. The physicochemical properties were determined by the injectability test, FTIR, SEM, and TGA. Porosity, degradation, bioactivity, possible cytotoxic effect, and proliferation in osteoblasts were also determined. The results show that the developed material has great potential to be used in bone tissue regeneration

show abstract

Microrheological study of PVA/borax physical gels: Effect of chain length and elastic reinforcement by sodium hydroxide addition

Cited by 21 publications

References 52 publications

Versatile and Extendable Boronate-Based Tunable Hydrogel Networks for Patterning Applications

Versatile and Extendable Boronate-Based Tunable Hydrogel Networks for Patterning Applications

Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO3 and Demineralized Bone Matrix

Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/borax /CaCO3 and Demineralized Bone Matrix

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