MicroRNA-1 in Cardiac Diseases and Cancers

Li, Jianzhe; Dong, Xiaomin; Wang, Zhongping; Wu, Jing

doi:10.4196/kjpp.2014.18.5.359

Cited by 34 publications

(24 citation statements)

References 59 publications

(70 reference statements)

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“…miR-145 and miR-1 have been reported to be aberrantly expressed in numerous types of cancer, and their tumor-suppressive roles have been well established. miR-1 is located at 18q11 in the human genome, and is abundantly expressed in the heart and skeletal muscle tissue (28). It has been demonstrated that miR-1 is among the most frequently downregulated miRs in solid human tumors.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of microRNA-1 and microRNA-145 contributes synergistically to the development of colon cancer

Jiang

et al. 2015

International Journal of Molecular Medicine

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The aim of the present study was to identify the differentially expressed microRNAs (miRNAs or miRs) in patients with colon cancer and examine their roles in the pathogenesis of the disease. The expression profiles of miRNAs were examined in tumor tissue samples collected from 20 patients with histologically confirmed colon cancer and in the adjacent non-cancerous control tissues using microarray analysis. We found that numerous miRNAs were differentially expressed in the colon cancer tissues compared with the control tissues. Following functional analysis, we noted that three miRNAs which were significantly downregulated, miR-145, miR-451 and miR-1, shared the same target gene, [NLR family, apoptosis inhibitory protein (NAIP)], which has previously been reported to be involved in the development of colon cancer. We then confirmed that NAIP is a target gene of miR-145 and miR-1, but not of miR-451, using a luceriferase assay, and we confirmed the expression patterns of these miRNAs and NAIP in the tumor tissue, as well as in the adjacent non-cancerous control tissues. Additionally, in order to examine the function of miR-145 and miR-1 in human colon cancer, we transiently transfected a human colon cancer cell line with miR-145 and miR-1 mimics or inhibitors, and the results of MTT assay revealed that the re-expression of miR-145 and miR-1 inhibited the survival of colon cancer cells, which may be attributed to the inhibition of the anti-apoptotic activity of NAIP. Our findings demonstrated that miR-145 and miR-1 play a negative regulatory role in the proliferation of colon cancer by targeting NAIP; thus, miR-145 and miR-1 may prove to be novel therapeutic targets in the treatment of colon cancer.

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Section: Discussionmentioning

confidence: 99%

Downregulation of microRNA-1 and microRNA-145 contributes synergistically to the development of colon cancer

Jiang

et al. 2015

International Journal of Molecular Medicine

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“…cardiac remodeling and heart failure (21). There is evidence that upregulated miR-1 expression is closely associated with cardiomyocyte apoptosis; in models of IR-, high glucose-or H 2 O 2 -induced cardiomyocyte apoptosis, miR-1 expression has been shown to be significantly increased (13,22,23).…”

mentioning

confidence: 99%

Paeoniflorin inhibits doxorubicin-induced cardiomyocyte apoptosis by downregulating microRNA-1 expression

Tang

Li³

et al. 2016

Experimental and Therapeutic Medicine

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Doxorubicin (DOX) is an effective anthracycline anti-tumor antibiotic. Because of its cardiotoxicity, the clinical application of DOX is limited. Paeoniflorin (PEF), a monoterpene glucoside extracted from the dry root of Paeonia, is reported to exert multiple beneficial effects on the cardiovascular system. The present study was designed to explore the protective effect of PEF against DOX-induced cardiomyocyte apoptosis and the underlying mechanism. In cultured H9c2 cells, PEF (100 µmol/l) was added for 2 h prior to exposure to DOX (5 µmol/l) for 24 h. Cell viability, creatine kinase activity, cardiomyocyte apoptosis, intracellular reactive oxygen species (ROS) levels, and the expression of microRNA-1 (miR-1) and B-cell lymphoma 2 (Bcl-2) were measured following treatment with PEF and/or DOX. The results showed that treatment with DOX notably induced cardiomyocyte apoptosis, concomitantly with enhanced ROS generation, upregulated miR-1 expression and downregulated Bcl-2 expression. These effects of DOX were significantly inhibited by pretreatment of the cells with PEF. These results suggest that the inhibitory effect of PEF on DOX-induced cardiomyocyte apoptosis may be associated with downregulation of miR-1 expression via a reduction in ROS generation.

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“…overlap with reduced expression of miR-1-1, and elevate miR-181c [15]. Additional data form Li et al, showed that let-7e-5p, miR-222-3p and miR-433 maybe the underlying cause for abnormalities since they target NOTCH1, HAND1, GATA3 , and ZFPM2 resulting in altered morphogenesis and VSD [27].…”

Section: Mirna's In Stem Cells To Cardiomyocyte Differentiationmentioning

confidence: 99%

“…A variant of miR-1(-1) is miR-1-2, has been found to have ~50% of embryonic lethality, while ~20% of survivors have major cardiac defects. Deletion miR-1-2 has been reported to repress Kcnd2, crucial factor in the repolarization of the heart [26][27][28]. In adult rats experiments miR-1 has been also revealed to target KCNQ1 and KCNE1 [18] The miR-17-92 cluster is has also been implicated in cardiac proliferation by negatively regulating PTEN tumor suppressor gene [9,29,30].…”

mentioning

confidence: 99%

microRNA Perspective on Cardiomyocyte Development and Cardiovascular Diseases

Islas¹,

Moreno-Cuevas²

2018

Preprint

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Study of micro-RNA regulatory networks (known as miRNA’s or miR’s), during development and in known pathologies have been the basis of study over the past decades. Herein, we recapitulate these findings in order to highlight the best underlying mechanisms found to date. We also seek to elucidate how miRNA dysregulation can be associated with many cardiovascular diseases. Furthermore, we discuss miR regulation mechanism during in early development in vivo and invitro. Since many of the miR’s are precursors to transcriptional regulation, we relate back to their molecular control as we can then look together at the fundamental disease they might be exacerbating by this dysregulation.

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MicroRNA-1 in Cardiac Diseases and Cancers

Cited by 34 publications

References 59 publications

Downregulation of microRNA-1 and microRNA-145 contributes synergistically to the development of colon cancer

Downregulation of microRNA-1 and microRNA-145 contributes synergistically to the development of colon cancer

Paeoniflorin inhibits doxorubicin-induced cardiomyocyte apoptosis by downregulating microRNA-1 expression

microRNA Perspective on Cardiomyocyte Development and Cardiovascular Diseases

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