microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2

Zhang, Feng; Li, Feiyan; Lu, Jinghe

doi:10.1016/j.cellsig.2022.110532

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…These collective mechanisms work synergistically, protecting against potential threats and reinforcing the tract's resilience in the face of microbial challenges. In recent studies, a paper has been published indicating the significant impact of exosomes derived from female vaginal discharge on the function and fertility of human sperm 44 .…”

Section: Mainmentioning

confidence: 99%

Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy

Kim,

Park,

Lee

et al. 2024

Preprint

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Preterm labor is a serious issue that can lead to preterm birth, posing significant risks to both the mother and the neonate. Despite the high incidence of approximately 15 million preterm births worldwide per year, there is a lack of sufficient strategies for predicting and preventing preterm labor. Here, we found that exosomal miRNAs in maternal vaginal discharge can serve as biomarkers for early diagnosis of life-threatening conditions in both the mother and neonate. Our non-invasive biopsy of vaginal discharge using a swab allows us to isolate enriched exosomes via an advanced microfluidic platform called BEST (Biologically intact Exosome Separation Technology). We have identified specific miRNAs differentially expressed in mothers with preterm labor compared to those with full-term mothers. These miRNAs included hsa-miR-206, which was up-regulated in preterm labor, and hsa-miR-3674, hsa-miR-365a-5p, and hsa-miR-193b-3p, which were down-regulated. We believe our discovery of unique miRNAs as biomarkers can aid in early detection and effective treatment of preterm labor, potentially revolutionizing global healthcare.

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Section: Mainmentioning

confidence: 99%

Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy

Kim,

Park,

Lee

et al. 2024

Preprint

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“…This modulation enhances migration and invasion of endometrial glandular epithelial cells (37). Zhang et al found that Huc-MSCsderived EVs carry miR-100 and act on ESCs, which promote proliferation, invasion, and migration of ESCs as well as epithelial-mesenchymal transition through inhibiting heparan 3-sulfotransferase 2 (71). Mast cells are granular immune cells that deposit in tissues, and there is growing evidence to support their involvement in the pathogenesis of EMs (72)(73)(74)(75).…”

Section: Evs Are Involved In Mediating Emsmentioning

confidence: 99%

Extracellular vesicles in endometriosis: role and potential

Chu,

Hou,

et al. 2024

Front. Endocrinol.

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Endometriosis is a chronic inflammatory gynecological disease, which profoundly jeopardizes women’s quality of life and places a significant medical burden on society. The pathogenesis of endometriosis remains unclear, posing major clinical challenges in diagnosis and treatment. There is an urgent demand for the development of innovative non-invasive diagnostic techniques and the identification of therapeutic targets. Extracellular vesicles, recognized for transporting a diverse array of signaling molecules, have garnered extensive attention as a novel mode of intercellular communication. A burgeoning body of research indicates that extracellular vesicles play a pivotal role in the pathogenesis of endometriosis, which may provide possibility and prospect for both diagnosis and treatment. In light of this context, this article focuses on the involvement of extracellular vesicles in the pathogenesis of endometriosis, which deliver information among endometrial stromal cells, macrophages, mesenchymal stem cells, and other cells, and explores their potential applications in the diagnosis and treatment, conducing to the emergence of new strategies for clinical diagnosis and treatment.

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Strategies and Challenges of Mesenchymal Stem Cells-Derived Extracellular Vesicles in Infertility

Li,

Wei,

et al. 2024

Tissue Engineering Part B: Reviews

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microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2

Cited by 4 publications

References 33 publications

Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy

Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy

Extracellular vesicles in endometriosis: role and potential

Strategies and Challenges of Mesenchymal Stem Cells-Derived Extracellular Vesicles in Infertility

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