MicroRNA-122 Regulation of HCV Infections: Insights from Studies of miR-122-Independent Replication

Panigrahi, Mamata; Palmer, Michaël; Jw, Wilson

doi:10.3390/pathogens11091005

Cited by 11 publications

(1 citation statement)

References 126 publications

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“…MicroRNAs (miRNAs) are small non‐coding RNAs (20–24 nucleotides) that regulate gene expression at a post‐transcriptional level by pairing to the 3′‐untranslated region (UTR) of their target mRNAs (Ambros, 2006). Increasingly, miRNAs have been found to play a key role in different viral infections (Akula et al, 2022; He et al, 2021; Panigrahi et al, 2022). It has been proved recently that altered expression of miRNAs in host cells is able to regulate the viral infection process (Eilam et al, 2018; Lin et al, 2020; Wang et al, 2019; Wu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

miR‐124 mediates the expression of ccBax to regulate Cyprinid herpesvirus 2 (CyHV‐2)‐induced apoptosis and viral replication

Zhang

Cheng

et al. 2023

Journal of Fish Diseases

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Cyprinid herpesvirus 2 (CyHV‐2), the etiological agent of herpesvirus haematopoietic necrosis (HVHN) in carp and goldfish, has caused significant economic losses in the aquaculture industry. During viral infection, the host initiates a series of active or passive defences to regulate the process of virus infection. Apoptosis is a key component of active cellular defence, and members of the Bcl‐2 family have been shown to play a critical role in the apoptotic process. However, the mechanism of action of the Bcl‐2 family in inducing apoptosis during CyHV‐2 infection remains unclear. In this study, we revealed the molecular mechanism of miRNA‐mediated silver crucian carp BAX (ccBax) in CyHV‐2‐induced apoptosis for the first time and demonstrated that the overexpression of miR‐124 suppressed ccBax expression and significantly down‐regulated apoptosis in caudal fin cells of Carassius auratus gibelio (GiCF), while miR‐124 inhibitors were the opposite. These studies indicated that miR‐124 inhibits CyHV‐2‐induced apoptosis by reducing the expression of ccBax. Furthermore, the fact that transfection of miR‐124 mimics promoted CyHV‐2 replication, whereas miR‐124 inhibitors inhibited CyHV‐2 replication, indicated that miR‐124 inhibited CyHV‐2‐induced apoptosis and contributed to viral replication. All these results suggested that miR‐124 suppresses virus‐induced apoptosis and promotes viral replication by targeting and regulating ccBax expression.

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Section: Introductionmentioning

confidence: 99%

miR‐124 mediates the expression of ccBax to regulate Cyprinid herpesvirus 2 (CyHV‐2)‐induced apoptosis and viral replication

Zhang

Cheng

et al. 2023

Journal of Fish Diseases

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A State‐of‐the‐Art Review on the Recent Advances in Exosomes in Oncogenic Virus

Ebrahimi,

Modaresi Movahedi,

Sabbaghian

et al. 2024

Health Science Reports

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Background and AimsOncogenic viruses are responsible for approximately 12% of human malignancies, influencing various cancer processes through intricate interactions with host cells. Exosomes (EXOs), nanometric‐sized microvesicles involved in cell communication, have emerged as critical mediators in these interactions. This review aims to explore the mechanisms by which EXOs produced by cells infected with oncogenic viruses promote cancer growth, enhance viral transmissibility, and act as immunomodulators.MethodsA comprehensive review was conducted, focusing on recent studies highlighting the mechanisms by which EXOs facilitate the oncogenic potential of viruses. The analysis included the characterization of exosomal content, such as microRNAs (miRNAs) and proteins, and their effects on tumor microenvironments and immune responses. A search was performed using databases including PubMed, ScienceDirect, and Google Scholar. MeSH keywords related to EXOs, oncogenic viruses, and cancer were used to retrieve relevant review, systematic, and research articles.ResultsFindings indicate that EXOs from oncogenic virus‐infected cells carry viral components that facilitate infection and inflammation. These EXOs alter the tumor microenvironment, contributing to the development of virus‐associated cancers. Additionally, the review highlights the growing interest among researchers regarding the implications of EXOs in cancer progression and their potential role in enhancing the oncogenicity of viruses.ConclusionThe findings underscore the pivotal role of EXOs in mediating the oncogenic effects of viruses, suggesting that targeting exosomal pathways may provide new therapeutic avenues for managing virus‐associated cancers. Further research is needed to fully elucidate the functional mechanisms of EXOs in viral oncogenesis.

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RNA-based nanomedicines and their clinical applications

Su,

Ji,

et al. 2023

Nano Res.

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MicroRNA-122 Regulation of HCV Infections: Insights from Studies of miR-122-Independent Replication

Cited by 11 publications

References 126 publications

miR‐124 mediates the expression of ccBax to regulate Cyprinid herpesvirus 2 (CyHV‐2)‐induced apoptosis and viral replication

miR‐124 mediates the expression of ccBax to regulate Cyprinid herpesvirus 2 (CyHV‐2)‐induced apoptosis and viral replication

A State‐of‐the‐Art Review on the Recent Advances in Exosomes in Oncogenic Virus

RNA-based nanomedicines and their clinical applications

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