MicroRNA-1291 Is Associated With Locoregional Metastases in Patients With Early-Stage Breast Cancer

Escuín, Daniel; López‐Vilaró, Laura; Bell, Olga; Móra, Josefina; Moral, Antonio; Peŕez, José Ignacio Arias; Arqueros, Cristina; Cajal, Teresa Ramón y; Lerma, Enrique; Barnadas, Agustí

doi:10.3389/fgene.2020.562114

Cited by 12 publications

(20 citation statements)

References 52 publications

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“…In this study, a panel of four miRNAs (miR-1291, miR-217, miR-455-3p, and miR-566) was identified as a novel diagnostic biomarker for AMI after an integrated analysis of two microarray results and a comparison of their AUC values using ROC analysis. Regarding the four miRNAs set, miR-1291 was found to have regulatory effects in many tumors (Escuin et al, 2020 ). On its side, miR-217 inhibits apoptosis of atherosclerotic endothelial cells via the TLR4/PI3K/Akt/NF-κB pathway (Jiang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are 19–25 nucleotides in length and regulate gene expression at the post-transcriptional level through direct binding to the 3′-UTR of target mRNAs, leading to the inhibition of mRNA translation or mRNA degradation (Filipowicz et al, 2008 ). At present, the number of human miRNAs exceeds 1,900, and the number of target genes is predicted to be in the range of 1,000 s. Some estimates indicate that miRNAs target more than 30% of the human genome (Escuin et al, 2020 ). MiRNAs can be produced by all cell types and come from a variety of cell sources, such as endothelial cells, monocytes and macrophages, vascular smooth cells and platelets, and possibly secreted in the blood encapsulated in microparticles (exosomes, microvesicles, and apoptotic bodies), or combined with proteins or high-density lipoproteins (HDL) (Navickas et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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A Four-MicroRNA Panel in Peripheral Blood Identified as an Early Biomarker to Diagnose Acute Myocardial Infarction

Chen

Bai

et al. 2021

Front. Physiol.

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Objective: This study aimed to evaluate suitable circulating microRNAs (miRNAs) as diagnostic biomarkers of acute myocardial infarction (AMI).Methods: Patients with AMI were enrolled as study participants. All patients with AMI coming from the Second Affiliated Hospital of Nantong University between October 1, 2017 and May 31, 2019 were screened. At the same time, 80 patients with coronary angiographic stenosis <50% during the same period were selected as the control group. Peripheral blood samples were collected at different time points (0, 6, 12, and 24 h after disease onset) to detect the expression of a previously identified promising four-microRNA panel. The expression levels of miRNAs were tested by real-time polymerase chain reaction (RT-PCR), and the receiver operating characteristic curve (ROC) was used to analyze the diagnostic value of circulating miRNAs.Results: Based on the inclusion and exclusion criteria, 80 patients with AMI and 80 controls were enrolled in this study. The expression of circulating miR-1291, miR-217, miR-455-3p, and miR-566 was significantly downregulated in patients with AMI compared with controls. The area under the ROC curve (AUC) of circulating miR-1291, miR-217, miR-455-3p, and miR-566 were 0.82, 0.79, 0.82, and 0.83, respectively. The AUC of these four miRNAs was 0.87 with 83% sensitivity and 87% specificity. The expression peaks of these four miRNAs occurred earlier than those of cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB). Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the targets of these four miRNAs were significantly enriched in several signaling pathways associated with AMI progression.Conclusion: Circulating miR-1291, miR-217, miR-455-3p, and miR-566 expression levels were significantly lower in patients with AMI; and combined, this panel of four miRNAs acted as a novel and potential early diagnostic biomarker of AMI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Four-MicroRNA Panel in Peripheral Blood Identified as an Early Biomarker to Diagnose Acute Myocardial Infarction

Chen

Bai

et al. 2021

Front. Physiol.

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“…A bioinformatic pathway analysis predicted that sd/miR-1291 regulates WNT signaling, planar cell polarity/convergent extension (PCP/CE) pathway, β-catenin independent WNT signaling, diseases of signal transduction, and signaling by receptor tyrosine kinases (RTKs), among others. While these results strongly suggest that sd/miR-1291 is a tumor-suppressing RNA, patient survival analysis revealed that expression of this sdRNA alone could not significantly predict patient survival [ 63 ].…”

Section: Sdrnas In Cancermentioning

confidence: 99%

Small Nucleolar Derived RNAs as Regulators of Human Cancer

et al. 2022

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In the past decade, RNA fragments derived from full-length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional. These sno-derived RNAs (sdRNAs) have been implicated as gene regulators in a multitude of cancers, controlling a variety of genes post-transcriptionally via association with the RNA-induced silencing complex (RISC). In this review, we have summarized the literature connecting sdRNAs to cancer gene regulation. SdRNAs possess miRNA-like functions and are able to fill the role of tumor-suppressing or tumor-promoting RNAs in a tissue context-dependent manner. Indeed, there are many miRNAs that are actually derived from snoRNA transcripts, meaning that they are truly sdRNAs and as such are included in this review. As sdRNAs are frequently discarded from ncRNA analyses, we emphasize that sdRNAs are functionally relevant gene regulators and likely represent an overlooked subclass of miRNAs. Based on the evidence provided by the papers reviewed here, we propose that sdRNAs deserve more extensive study to better understand their underlying biology and to identify previously overlooked biomarkers and therapeutic targets for a multitude of human cancers.

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“…MicroRNA (miRNA, miR) are involved in the pathological development and metastasis of cancer [16,17]. Several natural products showed an anti-cancer effect by regulation of cancer-related miRNAs.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review

et al. 2021

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Cervical cancer is the fourth most common cancer among women worldwide. Though several natural products have been reported regarding their efficacies against cervical cancer, there has been no review article that categorized them according to their anti-cancer mechanisms. In this study, anti-cancerous natural products against cervical cancer were collected using Pubmed (including Medline) and google scholar, published within three years. Their mechanisms were categorized as induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, reduction of resistance, and regulation of miRNAs. A total of 64 natural products suppressed cervical cancer. Among them, Penicillium sclerotiorum extracts from Cassia fistula L., ethanol extracts from Bauhinia variegate candida, thymoquinone obtained from Nigella sativa, lipid-soluble extracts of Pinellia pedatisecta Schott., and 1′S-1′-acetoxychavicol extracted from Alpinia conchigera have been shown to have multi-effects against cervical cancer. In conclusion, natural products could be attractive candidates for novel anti-cancer drugs.

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MicroRNA-1291 Is Associated With Locoregional Metastases in Patients With Early-Stage Breast Cancer

Cited by 12 publications

References 52 publications

A Four-MicroRNA Panel in Peripheral Blood Identified as an Early Biomarker to Diagnose Acute Myocardial Infarction

A Four-MicroRNA Panel in Peripheral Blood Identified as an Early Biomarker to Diagnose Acute Myocardial Infarction

Small Nucleolar Derived RNAs as Regulators of Human Cancer

Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review

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