MicroRNA-132 enhances transition from inflammation to proliferation during wound healing

The integrin αv-TGFβ signaling axis is necessary for epidermal proliferation during cutaneous wound healing

“…57 Also consistent with this, TGFb was shown to promote keratinocyte proliferation in an in vivo wound healing model through upregulation of miR-132, indicating that TGFb can have pleiotropic effects. 58 In addition, the expression and activity of several integrin heterodimers can be affected by ERK and AKT signaling. ERK signaling is known to up-regulate p38 activity, which can promote a3b1 mediated spreading and migration on laminin-332.…”

Effect of co-transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of hepatocellular carcinoma Huh7

“…MiR-132 usually expresses high in nerve-related tissues participating in the growth of axon, proliferation and differentiation of synapse and angiogenesis and possessing certain functions in immune regulation [16,17]. Studies have revealed that miR-132 can also participate in the occurrence and development of tumors and expresses low in tumor tissues of prostate cancer, liver cancer and so on [18] .…”

Noncoding RNAs in Wound Healing: A New and Vast Frontier

“…Corresponding wound models suppressing miRNA-132 revealed delayed wound healing with increased inflammation and decreased keratinocyte proliferation. 14 Next, the proliferative phase of wound healing is driven by the secretion of factors such as FGF, TGF-a and TGF-b, interleukin-1 (IL-1), and TNF-a. 13 While the importance of these chemotactic factors have been well studied, the influence of noncoding RNAs reveals an entirely new layer of regulation and coordination.…”